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HUMAN:DGAT1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DGAT1 (synonyms: AGRP1, DGAT)
Protein Name(s) Diacylglycerol O-acyltransferase 1

ACAT-related gene product 1 Acyl-CoA retinol O-fatty-acyltransferase ARAT Retinol O-fatty-acyltransferase Diglyceride acyltransferase

External Links
UniProt O75907
EMBL AF059202
AB057815
CH471162
CH471162
BC015762
BC023565
BC150649
CCDS CCDS6420.1
RefSeq NP_036211.2
UniGene Hs.521954
ProteinModelPortal O75907
BioGrid 114241
IntAct O75907
STRING 9606.ENSP00000332258
BindingDB O75907
ChEMBL CHEMBL6009
GuidetoPHARMACOLOGY 2821
PhosphoSite O75907
MaxQB O75907
PaxDb O75907
PRIDE O75907
DNASU 8694
Ensembl ENST00000528718
GeneID 8694
KEGG hsa:8694
UCSC uc003zbv.3
CTD 8694
GeneCards GC08M145539
HGNC HGNC:2843
HPA CAB032853
MIM 604900
615863
neXtProt NX_O75907
Orphanet 329242
PharmGKB PA27303
eggNOG COG5056
GeneTree ENSGT00530000063122
HOGENOM HOG000213917
HOVERGEN HBG051341
InParanoid O75907
KO K11155
OMA LWAFTAM
PhylomeDB O75907
TreeFam TF314921
Reactome REACT_1190
REACT_121122
UniPathway UPA00230
ChiTaRS DGAT1
GenomeRNAi 8694
NextBio 32607
PRO PR:O75907
Proteomes UP000005640
Bgee O75907
CleanEx HS_DGAT1
ExpressionAtlas O75907
Genevestigator O75907
GO GO:0005789
GO:0016021
GO:0004144
GO:0050252
GO:0016746
GO:0036155
GO:0044255
GO:0046339
GO:0046474
GO:0019915
GO:0035336
GO:0006644
GO:0044281
GO:0019432
GO:0006641
GO:0034379
InterPro IPR027251
IPR004299
IPR014371
PANTHER PTHR10408
Pfam PF03062
PIRSF PIRSF000439
PIRSF500231

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0046339

diacylglycerol metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z2A7

P

Seeded From UniProt

complete

involved_in

GO:0035336

long-chain fatty-acyl-CoA metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z2A7

P

Seeded From UniProt

complete

involved_in

GO:0034379

very-low-density lipoprotein particle assembly

PMID:15308631[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019915

lipid storage

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z2A7

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z2A7

C

Seeded From UniProt

complete

involved_in

GO:0019432

triglyceride biosynthetic process

PMID:18238778[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019432

triglyceride biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1333825
PANTHER:PTN000045226
RGD:628673
TAIR:locus:2047665
UniProtKB:I1MSF2
UniProtKB:O75907
UniProtKB:Q5GKZ7
dictyBase:DDB_G0271342

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000045225
UniProtKB:O75908
UniProtKB:P35610
UniProtKB:Q5GKZ7

C

Seeded From UniProt

complete

enables

GO:0004144

diacylglycerol O-acyltransferase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004797
MGI:MGI:1333825
PANTHER:PTN000045226
RGD:628673
TAIR:locus:2047665
UniProtKB:F1MIW3
UniProtKB:I1MSF2
UniProtKB:O75907
UniProtKB:Q5GKZ7
UniProtKB:Q8MK44

F

Seeded From UniProt

complete

involved_in

GO:0019432

triglyceride biosynthetic process

PMID:18458083[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004144

diacylglycerol O-acyltransferase activity

PMID:18458083[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042572

retinol metabolic process

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0050252

P

Seeded From UniProt

complete

involved_in

GO:0055089

fatty acid homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

P

Seeded From UniProt

complete

involved_in

GO:0046339

diacylglycerol metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

C

Seeded From UniProt

complete

involved_in

GO:0035336

long-chain fatty-acyl-CoA metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

P

Seeded From UniProt

complete

involved_in

GO:0019915

lipid storage

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

P

Seeded From UniProt

complete

involved_in

GO:0019432

triglyceride biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

C

Seeded From UniProt

complete

enables

GO:0004144

diacylglycerol O-acyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

F

Seeded From UniProt

complete

enables

GO:0003846

2-acylglycerol O-acyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z2A7
ensembl:ENSMUSP00000023214

F

Seeded From UniProt

complete

enables

GO:0004144

diacylglycerol O-acyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027251

F

Seeded From UniProt

complete

enables

GO:0008374

O-acyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014371

F

Seeded From UniProt

complete

involved_in

GO:0019432

triglyceride biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027251

P

Seeded From UniProt

complete

enables

GO:0050252

retinol O-fatty-acyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.76

F

Seeded From UniProt

complete

enables

GO:0004144

diacylglycerol O-acyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.20

F

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

PMID:9756920[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006641

triglyceride metabolic process

PMID:9756920[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004144

diacylglycerol O-acyltransferase activity

PMID:9789033[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036155

acylglycerol acyl-chain remodeling

Reactome:R-HSA-1482883

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035579

specific granule membrane

Reactome:R-HSA-6799350

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0019432

triglyceride biosynthetic process

Reactome:R-HSA-75109

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-6799350

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

Reactome:R-HSA-75900
Reactome:R-HSA-1482889

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

involved_in

GO:0046486

glycerolipid metabolic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00230

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Liang, JJ et al. (2004) Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. J. Biol. Chem. 279 44938-44 PubMed GONUTS page
  2. ↑ Chen, YQ et al. (2008) AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. J. Biol. Chem. 283 10048-57 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Cao, J et al. (2008) Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. J. Biol. Chem. 283 19049-57 PubMed GONUTS page
  5. ↑ 5.0 5.1 Oelkers, P et al. (1998) Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273 26765-71 PubMed GONUTS page
  6. ↑ Cases, S et al. (1998) Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. U.S.A. 95 13018-23 PubMed GONUTS page
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