HUMAN:DEF4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DEFA4 (synonyms: DEF4)
Protein Name(s)	Neutrophil defensin 4 Defensin, alpha 4 HNP-4 HP-4
External Links
UniProt	P12838
EMBL	U18745 AF200455 CH471153 BC093959 BC106747 BC112091 X65977
CCDS	CCDS5961.1
PIR	A47365
RefSeq	NP_001916.1
UniGene	Hs.591391
PDB	1ZMM
PDBsum	1ZMM
ProteinModelPortal	P12838
SMR	P12838
IntAct	P12838
STRING	9606.ENSP00000297435
DMDM	399352
PaxDb	P12838
PRIDE	P12838
Ensembl	ENST00000297435
GeneID	1669
KEGG	hsa:1669
UCSC	uc003wqu.1
CTD	1669
GeneCards	GC08M006780
HGNC	HGNC:2763
HPA	HPA051266
MIM	601157
neXtProt	NX_P12838
PharmGKB	PA27240
eggNOG	NOG145841
GeneTree	ENSGT00730000111183
HOGENOM	HOG000233351
HOVERGEN	HBG011703
InParanoid	P12838
KO	K05230
OMA	CQRTELR
OrthoDB	EOG75TMFQ
PhylomeDB	P12838
TreeFam	TF338414
Reactome	REACT_115574 REACT_115846
EvolutionaryTrace	P12838
GeneWiki	DEFA4
GenomeRNAi	1669
NextBio	6868
PRO	PR:P12838
Proteomes	UP000005640
Bgee	P12838
CleanEx	HS_DEFA4
Genevestigator	P12838
GO	GO:0005576 GO:0005615 GO:0005796 GO:0019731 GO:0050832 GO:0045087 GO:0031640
InterPro	IPR016327 IPR006080 IPR002366 IPR006081
PANTHER	PTHR11876
Pfam	PF00323 PF00879
PIRSF	PIRSF001875
SMART	SM00048
PROSITE	PS00269

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042742	defense response to bacterium	PMID:2500436^[1]	ECO:0000314			P		table 2	complete
	GO:0044194	cytolytic granule	PMID:2500436^[1]	ECO:0000314			C		microbicidal assays, figure 1 in experimental procedures. purified and isolated granules and showed that the proteins came from the granules.	complete
enables	GO:0042803	protein homodimerization activity	PMID:17088326^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042582	azurophil granule	PMID:2500436^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316	P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59665 UniProtKB:P59666	P		Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99584 MGI:MGI:99592 PANTHER:PTN002275316	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99582 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:99584 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99584 PANTHER:PTN002275315 UniProtKB:P59666	C		Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P59665 UniProtKB:P59666	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006080 InterPro:IPR006081	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016327	C		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002366 InterPro:IPR006080 InterPro:IPR006081 InterPro:IPR016327	P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15616305^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15616305^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15616305^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15616305^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:17088326^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:17088326^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:15616305^[4]	ECO:0000305	curator inference used in manual assertion	GO:0031640	P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15616305^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15616305^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010818	T cell chemotaxis	PMID:17088326^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_movement_of:(CL:0000492) part_of:(CL:2000001)	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:17088326^[2]	ECO:0000305	curator inference used in manual assertion	GO:0010818,GO:0031640	P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	Reactome:R-HSA-6803157	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-1462023	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798749 Reactome:R-HSA-1462014 Reactome:R-HSA-1461982 Reactome:R-HSA-1461971	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0295	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0295	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0211	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Wilde, CG et al. (1989) Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J. Biol. Chem. 264 11200-3 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Szyk, A et al. (2006) Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 15 2749-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Ericksen, B et al. (2005) Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob. Agents Chemother. 49 269-75 PubMed GONUTS page

[PMID:2500436-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Wilde, CG et al. (1989) Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J. Biol. Chem. 264 11200-3 PubMed GONUTS page

[PMID:17088326-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Szyk, A et al. (2006) Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 15 2749-60 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15616305-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Ericksen, B et al. (2005) Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob. Agents Chemother. 49 269-75 PubMed GONUTS page

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HUMAN:DEF4

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