HUMAN:DDX49

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DDX49
Protein Name(s)	Probable ATP-dependent RNA helicase DDX49 DEAD box protein 49
External Links
UniProt	Q9Y6V7
EMBL	AK223294 AC002985 CH471106 BC000979 BC002674
CCDS	CCDS12390.1
RefSeq	NP_061943.2
UniGene	Hs.143187
ProteinModelPortal	Q9Y6V7
SMR	Q9Y6V7
BioGrid	120040
IntAct	Q9Y6V7
MINT	Q9Y6V7
STRING	9606.ENSP00000247003
iPTMnet	Q9Y6V7
PhosphoSitePlus	Q9Y6V7
BioMuta	DDX49
DMDM	74753527
EPD	Q9Y6V7
PaxDb	Q9Y6V7
PeptideAtlas	Q9Y6V7
PRIDE	Q9Y6V7
DNASU	54555
Ensembl	ENST00000247003
GeneID	54555
KEGG	hsa:54555
UCSC	uc002nkq.3
CTD	54555
EuPathDB	HostDB:ENSG00000105671.11
GeneCards	DDX49
HGNC	HGNC:18684
HPA	HPA041870 HPA048093
neXtProt	NX_Q9Y6V7
OpenTargets	ENSG00000105671
PharmGKB	PA134956171
eggNOG	KOG0330 ENOG410XQU7
GeneTree	ENSGT00730000111231
HOGENOM	HOG000205323
HOVERGEN	HBG100512
InParanoid	Q9Y6V7
KO	K14778
OMA	ISIFRFP
OrthoDB	EOG091G07QH
PhylomeDB	Q9Y6V7
TreeFam	TF320511
Reactome	R-HSA-6790901 R-HSA-6791226
GenomeRNAi	54555
PRO	PR:Q9Y6V7
Proteomes	UP000005640
Bgee	ENSG00000105671
CleanEx	HS_DDX49
ExpressionAtlas	Q9Y6V7
Genevisible	Q9Y6V7
GO	GO:0005737 GO:0005730 GO:0005654 GO:0005524 GO:0004004 GO:0003723 GO:0010501 GO:0006364
CDD	cd00079
InterPro	IPR011545 IPR014001 IPR001650 IPR027417 IPR000629 IPR014014
Pfam	PF00270 PF00271
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS00039 PS51192 PS51194 PS51195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030307	positive regulation of cell growth	PMID:29618122	ECO:0000315			P		HeLa cells were transfected with control siRNA, DDX49 siRNA, pEGFP-C1 vector or pEGFP-DDX49 construct as indicated and the cell numbers were counted at 48, 72 and 96 hours post-transfection. The colony forming potential was analyzed in cells treated with control siRNA, DDX49 siRNA, pEGFP-C1 vector or pEGFP-DDX49 construct as indicated(Figure 5C, D). They observed a very strong reduction in colony forming ability of DDX49 depleted cells suggesting that DDX49 is essential for proper cell growth and proliferation (Figure 5C)	complete CACAO 13288
	GO:0044357	regulation of rRNA stability	PMID:29618122	ECO:0000315			P		They assessed the stability of 47S rRNA by actinomycin D pulse chase assay and found that the siRNA mediated depletion of DDX49 substantially reduced the stability of 47S rRNA, while the overexpression of DDX49 did not show any alterations (Figure 4B). This suggests that DDX49 is required to stabilize the 47S rRNA.	complete CACAO 13289
enables	GO:0003723	RNA binding	PMID:22658674	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F		Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	Reactome:R-HSA-6791226	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6791228 Reactome:R-HSA-6791227 Reactome:R-HSA-6791222 Reactome:R-HSA-6791221	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
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References

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