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HUMAN:DDC
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DDC (synonyms: AADC) | |
| Protein Name(s) | Aromatic-L-amino-acid decarboxylase
AADC DOPA decarboxylase DDC | |
| External Links | ||
| UniProt | P20711 | |
| EMBL | M76180 M88700 M84592 M84600 M84593 M84594 M84596 M84597 M84595 M84598 M84599 M84588 M84589 M84590 M84591 AJ310724 AY526322 AC018705 BC000485 BC008366 AH005280 S46516 | |
| CCDS | CCDS5511.1 CCDS56485.1 CCDS56486.1 CCDS56487.1 | |
| PIR | A33663 | |
| RefSeq | NP_000781.1 NP_001076440.1 NP_001229815.1 NP_001229816.1 NP_001229817.1 NP_001229818.1 NP_001229819.1 | |
| UniGene | Hs.359698 | |
| PDB | 3RBF 3RBL 3RCH | |
| PDBsum | 3RBF 3RBL 3RCH | |
| ProteinModelPortal | P20711 | |
| SMR | P20711 | |
| BioGrid | 108011 | |
| DIP | DIP-40563N | |
| IntAct | P20711 | |
| STRING | 9606.ENSP00000350616 | |
| ChEMBL | CHEMBL1843 | |
| DrugBank | DB00915 DB00190 DB00260 DB06262 DB00875 DB01235 DB00150 DB00968 | |
| GuidetoPHARMACOLOGY | 1271 | |
| PhosphoSite | P20711 | |
| DMDM | 311033369 | |
| MaxQB | P20711 | |
| PaxDb | P20711 | |
| PRIDE | P20711 | |
| DNASU | 1644 | |
| Ensembl | ENST00000357936 ENST00000380984 ENST00000426377 ENST00000431062 ENST00000444124 ENST00000615193 | |
| GeneID | 1644 | |
| KEGG | hsa:1644 | |
| CTD | 1644 | |
| GeneCards | GC07M050526 | |
| H-InvDB | HIX0006684 | |
| HGNC | HGNC:2719 | |
| HPA | HPA017742 | |
| MIM | 107930 608643 | |
| neXtProt | NX_P20711 | |
| Orphanet | 35708 | |
| PharmGKB | PA140 | |
| eggNOG | COG0076 | |
| GeneTree | ENSGT00760000119205 | |
| HOGENOM | HOG000121941 | |
| HOVERGEN | HBG000944 | |
| InParanoid | P20711 | |
| KO | K01593 | |
| OMA | PICNKED | |
| OrthoDB | EOG75B851 | |
| PhylomeDB | P20711 | |
| TreeFam | TF313863 | |
| BioCyc | MetaCyc:HS05635-MONOMER | |
| BRENDA | 4.1.1.28 | |
| Reactome | REACT_15439 REACT_15551 | |
| UniPathway | UPA00747 | |
| GenomeRNAi | 1644 | |
| NextBio | 35484171 | |
| PRO | PR:P20711 | |
| Proteomes | UP000005640 | |
| Bgee | P20711 | |
| CleanEx | HS_DDC | |
| ExpressionAtlas | P20711 | |
| Genevestigator | P20711 | |
| GO | GO:0030424 GO:0005829 GO:0070062 GO:0043025 GO:0008021 GO:0016597 GO:0004058 GO:0019899 GO:0036468 GO:0030170 GO:0042423 GO:0006520 GO:0034641 GO:0071312 GO:0035690 GO:0071363 GO:0007623 GO:0042416 GO:0046219 GO:0033076 GO:0010259 GO:0052314 GO:0046684 GO:0042427 GO:0044281 GO:0015842 | |
| Gene3D | 3.40.640.10 3.90.1150.10 | |
| InterPro | IPR010977 IPR002129 IPR015424 IPR015421 IPR015422 IPR021115 | |
| Pfam | PF00282 | |
| PRINTS | PR00800 | |
| SUPFAM | SSF53383 | |
| PROSITE | PS00392 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006587 |
serotonin biosynthetic process from tryptophan |
ECO:0000314 |
P |
Table 2 |
complete | |||||
|
enables |
GO:0036468 |
L-dopa decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004058 |
aromatic-L-amino-acid decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009636 |
response to toxic substance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O88533 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O88533 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004058 |
aromatic-L-amino-acid decarboxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O88533 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071363 |
cellular response to growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071312 |
cellular response to alkaloid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0052314 |
phytoalexin metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046684 |
response to pyrethroid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042427 |
serotonin biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042416 |
dopamine biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033076 |
isoquinoline alkaloid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030170 |
pyridoxal phosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016597 |
amino acid binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0015842 |
aminergic neurotransmitter loading into synaptic vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010259 |
multicellular organism aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004058 |
aromatic-L-amino-acid decarboxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14173 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006520 |
cellular amino acid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016831 |
carboxy-lyase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019752 |
carboxylic acid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030170 |
pyridoxal phosphate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004058 |
aromatic-L-amino-acid decarboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004058 |
aromatic-L-amino-acid decarboxylase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046219 |
indolalkylamine biosynthetic process |
Reactome:R-HSA-209931 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042423 |
catecholamine biosynthetic process |
Reactome:R-HSA-209905 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-209924 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0042423 |
catecholamine biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016831 |
carboxy-lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042416 |
dopamine biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00747 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ UDENFRIEND, S et al. (1956) Biogenesis and metabolism of 5-hydroxyindole compounds. J. Biol. Chem. 219 335-44 PubMed GONUTS page
- ↑ 2.0 2.1 Ishikawa, S et al. (2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. J. Biol. Chem. 284 28832-44 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Duan, CL et al. (2005) The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD. Brain Res. Brain Res. Protoc. 16 37-43 PubMed GONUTS page
- ↑ Rorsman, F et al. (1995) Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Proc. Natl. Acad. Sci. U.S.A. 92 8626-9 PubMed GONUTS page
a
c
- GO:0016831 ! carboxy-lyase activity
- GO:0019752 ! carboxylic acid metabolic process
- GO:0003824 ! catalytic activity
- Catarrhini
- GO:0042423 ! catecholamine biosynthetic process
- GO:0035690 ! cellular response to drug
- GO:0071363 ! cellular response to growth factor stimulus
- GO:0071312 ! cellular response to alkaloid
- Chordata
- GO:0007623 ! circadian rhythm
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
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