HUMAN:CYR61

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CYR61 (synonyms: CCN1, GIG1, IGFBP10)
Protein Name(s)	Protein CYR61 CCN family member 1 Cysteine-rich angiogenic inducer 61 Insulin-like growth factor-binding protein 10 IBP-10 IGF-binding protein 10 IGFBP-10 Protein GIG1
External Links
UniProt	O00622
EMBL	U62015 Y11307 Y12084 AF003594 AF031385 Z98053 AF307860 AY443495 BC001271 BC009199 BC016952
CCDS	CCDS706.1
RefSeq	NP_001545.2
UniGene	Hs.8867
ProteinModelPortal	O00622
SMR	O00622
BioGrid	109712
IntAct	O00622
MINT	MINT-4993925
STRING	9606.ENSP00000398736
PhosphoSite	O00622
MaxQB	O00622
PaxDb	O00622
PRIDE	O00622
DNASU	3491
Ensembl	ENST00000451137
GeneID	3491
KEGG	hsa:3491
UCSC	uc001dle.3
CTD	3491
GeneCards	GC01P086046
HGNC	HGNC:2654
HPA	HPA029853
MIM	602369
neXtProt	NX_O00622
PharmGKB	PA27126
eggNOG	NOG82014
HOGENOM	HOG000231462
HOVERGEN	HBG000635
InParanoid	O00622
KO	K06829
OMA	KCIVQTT
OrthoDB	EOG7N8ZXB
PhylomeDB	O00622
TreeFam	TF326070
ChiTaRS	CYR61
GeneWiki	CYR61
GenomeRNAi	3491
NextBio	13730
PMAP-CutDB	O00622
PRO	PR:O00622
Proteomes	UP000005640
Bgee	O00622
CleanEx	HS_CYR61
ExpressionAtlas	O00622
Genevestigator	O00622
GO	GO:0031012 GO:0005576 GO:0050840 GO:0008201 GO:0009653 GO:0003278 GO:0060413 GO:0003181 GO:0008283 GO:0006935 GO:0060591 GO:0060710 GO:0030198 GO:0002041 GO:0060716 GO:0043066 GO:0001649 GO:0030513 GO:0061036 GO:0030335 GO:0010811 GO:2000304 GO:0043280 GO:0045669 GO:0033690 GO:0010518 GO:0045860 GO:0001934 GO:0045944 GO:0072593 GO:0001558 GO:0070372 GO:0003281 GO:0044319
InterPro	IPR006207 IPR006208 IPR009030 IPR000867 IPR012395 IPR017891 IPR000884 IPR001007
Pfam	PF00007 PF00219 PF00090 PF00093
PIRSF	PIRSF036495
SMART	SM00041 SM00121 SM00209 SM00214
SUPFAM	SSF57184 SSF82895
PROSITE	PS01185 PS01225 PS00222 PS51323 PS50092 PS01208 PS50184

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0005201	extracellular matrix structural constituent	PMID:28327460^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002551)\|occurs_in:(CL:0002570)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002570)\|part_of:(CL:0002551)	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033690	positive regulation of osteoblast proliferation	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:20675382^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21274	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:20675382^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000142748 RGD:621392	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95537 PANTHER:PTN000142748	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95537 PANTHER:PTN000142748	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88613 PANTHER:PTN000142748 RGD:620763	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88613 MGI:MGI:95537 PANTHER:PTN000142748 UniProtKB:P48745	F		Seeded From UniProt	complete
involved_in	GO:2000304	positive regulation of ceramide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0060716	labyrinthine layer blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0060710	chorio-allantoic fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0060591	chondroblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0060413	atrial septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
enables	GO:0050840	extracellular matrix binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	F		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0010811	positive regulation of cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0010518	positive regulation of phospholipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	F		Seeded From UniProt	complete
involved_in	GO:0003281	ventricular septum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0003278	apoptotic process involved in heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0002041	intussusceptive angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18406 ensembl:ENSMUSP00000029846	P		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000867	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000867	C		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0340	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Su, JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J. Biol. Chem. 285 31325-36 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28327460-1] 1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:20675382-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Su, JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J. Biol. Chem. 285 31325-36 PubMed GONUTS page

[PMID:23658023-3] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:CYR61

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Annotations

Notes

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