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HUMAN:CTF1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CTF1
Protein Name(s) Cardiotrophin-1

CT-1

External Links
UniProt Q16619
EMBL U43033
U43031
U43032
U43030
AC135048
BC036787
BC064416
CCDS CCDS10694.1
CCDS45464.1
PIR G02312
RefSeq NP_001136016.1
NP_001321.1
UniGene Hs.483811
ProteinModelPortal Q16619
BioGrid 107871
DIP DIP-394N
STRING 9606.ENSP00000279804
DMDM 2498265
PaxDb Q16619
PRIDE Q16619
Ensembl ENST00000279804
ENST00000395019
GeneID 1489
KEGG hsa:1489
UCSC uc002dzw.3
uc002dzx.3
CTD 1489
GeneCards GC16P030910
HGNC HGNC:2499
HPA CAB025853
MIM 600435
neXtProt NX_Q16619
PharmGKB PA27002
eggNOG NOG44809
GeneTree ENSGT00510000049046
HOGENOM HOG000112040
HOVERGEN HBG000455
InParanoid Q16619
KO K05422
OMA LYREWVS
OrthoDB EOG7VHSZW
PhylomeDB Q16619
TreeFam TF333266
SignaLink Q16619
GenomeRNAi 1489
NextBio 6119
PRO PR:Q16619
Proteomes UP000005640
Bgee Q16619
CleanEx HS_CTF1
Genevestigator Q16619
GO GO:0005576
GO:0005615
GO:0005146
GO:0008283
GO:0007267
GO:0048861
GO:0007517
GO:0007399
GO:0048666
GO:0008284
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR010681
PANTHER PTHR21353
SUPFAM SSF47266

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042517

positive regulation of tyrosine phosphorylation of Stat3 protein

PMID:21912637[1]

ECO:0000314

P

Figure 6 - shows CT1 positive regulation of STAT3 phosphorylation.

complete
CACAO 7580

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

PMID:21912637[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1930088
PANTHER:PTN001085373

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001085373
UniProtKB:Q9UBD9

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1930088
PANTHER:PTN001085373
RGD:2442
UniProtKB:Q9UBD9

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0048666

neuron development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60753
ensembl:ENSMUSP00000049161

P

Seeded From UniProt

complete

involved_in

GO:0048861

leukemia inhibitory factor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63086
ensembl:ENSRNOP00000025646

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63086
ensembl:ENSRNOP00000025646

P

Seeded From UniProt

complete

enables

GO:0005146

leukemia inhibitory factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63086
ensembl:ENSRNOP00000025646

F

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63086
ensembl:ENSRNOP00000025646

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:7862649[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007517

muscle organ development

PMID:8833032[4]
PMID:7862649[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:7738033[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

PMID:7862649[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:7862649[3]
Reactome:R-HSA-6783524
Reactome:R-HSA-5696482

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0005146

leukemia inhibitory factor receptor binding

PMID:8833032[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6783589

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page
  2. 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Pennica, D et al. (1995) Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. U.S.A. 92 1142-6 PubMed GONUTS page
  4. 4.0 4.1 Pennica, D et al. (1996) Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. Cytokine 8 183-9 PubMed GONUTS page
  5. Pennica, D et al. (1995) Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J. Biol. Chem. 270 10915-22 PubMed GONUTS page