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HUMAN:CTF1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | CTF1 | |
Protein Name(s) | Cardiotrophin-1
CT-1 | |
External Links | ||
UniProt | Q16619 | |
EMBL | U43033 U43031 U43032 U43030 AC135048 BC036787 BC064416 | |
CCDS | CCDS10694.1 CCDS45464.1 | |
PIR | G02312 | |
RefSeq | NP_001136016.1 NP_001321.1 | |
UniGene | Hs.483811 | |
ProteinModelPortal | Q16619 | |
BioGrid | 107871 | |
DIP | DIP-394N | |
STRING | 9606.ENSP00000279804 | |
DMDM | 2498265 | |
PaxDb | Q16619 | |
PRIDE | Q16619 | |
Ensembl | ENST00000279804 ENST00000395019 | |
GeneID | 1489 | |
KEGG | hsa:1489 | |
UCSC | uc002dzw.3 uc002dzx.3 | |
CTD | 1489 | |
GeneCards | GC16P030910 | |
HGNC | HGNC:2499 | |
HPA | CAB025853 | |
MIM | 600435 | |
neXtProt | NX_Q16619 | |
PharmGKB | PA27002 | |
eggNOG | NOG44809 | |
GeneTree | ENSGT00510000049046 | |
HOGENOM | HOG000112040 | |
HOVERGEN | HBG000455 | |
InParanoid | Q16619 | |
KO | K05422 | |
OMA | LYREWVS | |
OrthoDB | EOG7VHSZW | |
PhylomeDB | Q16619 | |
TreeFam | TF333266 | |
SignaLink | Q16619 | |
GenomeRNAi | 1489 | |
NextBio | 6119 | |
PRO | PR:Q16619 | |
Proteomes | UP000005640 | |
Bgee | Q16619 | |
CleanEx | HS_CTF1 | |
Genevestigator | Q16619 | |
GO | GO:0005576 GO:0005615 GO:0005146 GO:0008283 GO:0007267 GO:0048861 GO:0007517 GO:0007399 GO:0048666 GO:0008284 | |
Gene3D | 1.20.1250.10 | |
InterPro | IPR009079 IPR012351 IPR010681 | |
PANTHER | PTHR21353 | |
SUPFAM | SSF47266 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Figure 6 - shows CT1 positive regulation of STAT3 phosphorylation. |
complete | |||||
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1930088 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001085373 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1930088 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048666 |
neuron development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048861 |
leukemia inhibitory factor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005146 |
leukemia inhibitory factor receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005125 |
cytokine activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007517 |
muscle organ development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
PMID:7862649[3] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0005146 |
leukemia inhibitory factor receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6783589 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Pennica, D et al. (1995) Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. U.S.A. 92 1142-6 PubMed GONUTS page
- ↑ 4.0 4.1 Pennica, D et al. (1996) Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. Cytokine 8 183-9 PubMed GONUTS page
- ↑ Pennica, D et al. (1995) Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J. Biol. Chem. 270 10915-22 PubMed GONUTS page
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