GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:CTF1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CTF1 | |
| Protein Name(s) | Cardiotrophin-1
CT-1 | |
| External Links | ||
| UniProt | Q16619 | |
| EMBL | U43033 U43031 U43032 U43030 AC135048 BC036787 BC064416 | |
| CCDS | CCDS10694.1 CCDS45464.1 | |
| PIR | G02312 | |
| RefSeq | NP_001136016.1 NP_001321.1 | |
| UniGene | Hs.483811 | |
| ProteinModelPortal | Q16619 | |
| BioGrid | 107871 | |
| DIP | DIP-394N | |
| STRING | 9606.ENSP00000279804 | |
| DMDM | 2498265 | |
| PaxDb | Q16619 | |
| PRIDE | Q16619 | |
| Ensembl | ENST00000279804 ENST00000395019 | |
| GeneID | 1489 | |
| KEGG | hsa:1489 | |
| UCSC | uc002dzw.3 uc002dzx.3 | |
| CTD | 1489 | |
| GeneCards | GC16P030910 | |
| HGNC | HGNC:2499 | |
| HPA | CAB025853 | |
| MIM | 600435 | |
| neXtProt | NX_Q16619 | |
| PharmGKB | PA27002 | |
| eggNOG | NOG44809 | |
| GeneTree | ENSGT00510000049046 | |
| HOGENOM | HOG000112040 | |
| HOVERGEN | HBG000455 | |
| InParanoid | Q16619 | |
| KO | K05422 | |
| OMA | LYREWVS | |
| OrthoDB | EOG7VHSZW | |
| PhylomeDB | Q16619 | |
| TreeFam | TF333266 | |
| SignaLink | Q16619 | |
| GenomeRNAi | 1489 | |
| NextBio | 6119 | |
| PRO | PR:Q16619 | |
| Proteomes | UP000005640 | |
| Bgee | Q16619 | |
| CleanEx | HS_CTF1 | |
| Genevestigator | Q16619 | |
| GO | GO:0005576 GO:0005615 GO:0005146 GO:0008283 GO:0007267 GO:0048861 GO:0007517 GO:0007399 GO:0048666 GO:0008284 | |
| Gene3D | 1.20.1250.10 | |
| InterPro | IPR009079 IPR012351 IPR010681 | |
| PANTHER | PTHR21353 | |
| SUPFAM | SSF47266 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Figure 6 - shows CT1 positive regulation of STAT3 phosphorylation. |
complete | |||||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1930088 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001085373 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1930088 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048666 |
neuron development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60753 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048861 |
leukemia inhibitory factor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005146 |
leukemia inhibitory factor receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63086 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007517 |
muscle organ development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
PMID:7862649[3] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005146 |
leukemia inhibitory factor receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6783589 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Pennica, D et al. (1995) Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. U.S.A. 92 1142-6 PubMed GONUTS page
- ↑ 4.0 4.1 Pennica, D et al. (1996) Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. Cytokine 8 183-9 PubMed GONUTS page
- ↑ Pennica, D et al. (1995) Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J. Biol. Chem. 270 10915-22 PubMed GONUTS page
c
e
l
n
p
