HUMAN:CSPG2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	VCAN (synonyms: CSPG2)
Protein Name(s)	Versican core protein Chondroitin sulfate proteoglycan core protein 2 Chondroitin sulfate proteoglycan 2 Glial hyaluronate-binding protein GHAP Large fibroblast proteoglycan PG-M
External Links
UniProt	P13611
EMBL	X15998 U16306 U26555 D32039 S52488 J02814 AF084545
CCDS	CCDS4060.1 CCDS47242.1 CCDS54875.1 CCDS54876.1
PIR	S06014
RefSeq	NP_001119808.1 NP_001157569.1 NP_001157570.1 NP_004376.2
UniGene	Hs.643801
ProteinModelPortal	P13611
SMR	P13611
BioGrid	107844
IntAct	P13611
MINT	MINT-4529155
STRING	9606.ENSP00000265077
DrugBank	DB08818
PhosphoSite	P13611
DMDM	2506816
MaxQB	P13611
PaxDb	P13611
PRIDE	P13611
DNASU	1462
Ensembl	ENST00000265077 ENST00000342785 ENST00000343200 ENST00000502527
GeneID	1462
KEGG	hsa:1462
UCSC	uc003kii.3 uc003kij.3 uc003kik.3 uc010jau.2
CTD	1462
GeneCards	GC05P082804
GeneReviews	VCAN
HGNC	HGNC:2464
HPA	CAB008979 HPA004726
MIM	118661 143200
neXtProt	NX_P13611
Orphanet	898
PharmGKB	PA162408788
eggNOG	NOG12793
GeneTree	ENSGT00760000119025
HOVERGEN	HBG051140
InParanoid	P13611
KO	K06793
OMA	TQEEFPW
OrthoDB	EOG7J70DP
PhylomeDB	P13611
TreeFam	TF332134
Reactome	REACT_120800 REACT_120888 REACT_120989 REACT_121408 REACT_163906 REACT_267642 REACT_267659 REACT_267682 REACT_267708 REACT_267711
ChiTaRS	VCAN
GeneWiki	Versican
GenomeRNAi	1462
NextBio	6005
PMAP-CutDB	P13611
PRO	PR:P13611
Proteomes	UP000005640
Bgee	P13611
CleanEx	HS_VCAN
ExpressionAtlas	P13611
Genevestigator	P13611
GO	GO:0031012 GO:0005576 GO:0005615 GO:0005796 GO:0043231 GO:0043202 GO:0016020 GO:0005578 GO:0005509 GO:0030246 GO:0005539 GO:0005540 GO:0005975 GO:0007155 GO:0008037 GO:0030206 GO:0030207 GO:0030204 GO:0030208 GO:0030198 GO:0008347 GO:0030203 GO:0007507 GO:0007275 GO:0001649 GO:0044281
Gene3D	2.60.40.10 3.10.100.10
InterPro	IPR001304 IPR016186 IPR018378 IPR016187 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR007110 IPR013783 IPR003599 IPR013106 IPR000538 IPR000436
Pfam	PF00008 PF00059 PF00084 PF07686 PF00193
PRINTS	PR01265
SMART	SM00032 SM00034 SM00181 SM00179 SM00409 SM00445
SUPFAM	SSF56436 SSF57535
PROSITE	PS00010 PS00615 PS50041 PS00022 PS01186 PS50026 PS01187 PS50835 PS01241 PS50963 PS50923

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:28327460^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002540)\|occurs_in:(CL:0002570)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)\|part_of:(CL:0002570)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1SX59	F	occurs_in:(UBERON:0002084)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:20551380^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001496)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:27559042^[3]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0006618) occurs_in:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:28675934^[4]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0003688)\|occurs_in:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:25037231^[5]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16210410^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000134)\|part_of:(CL:0000062)	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:16210410^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P	results_in_determination_of:(CL:0000134)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:20551380^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:22261194^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1SX59	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20551380^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102889 MGI:MGI:1096385 MGI:MGI:1337006 MGI:MGI:2137300 MGI:MGI:99602 PANTHER:PTN001105676	C		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001105676 RGD:68358	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001105676 ZFIN:ZDB-GENE-030131-2185	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
enables	GO:0005540	hyaluronic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000538	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000538	P		Seeded From UniProt	complete
involved_in	GO:0008347	glial cell migration	PMID:18431253^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008347	glial cell migration	PMID:18431253^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008037	cell recognition	PMID:2583089^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:2583089^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:2583089^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:2583089^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005540	hyaluronic acid binding	PMID:2583089^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	PMID:7528742^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043202	lysosomal lumen	Reactome:R-HSA-2065233 Reactome:R-HSA-2022056 Reactome:R-HSA-1793176	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030208	dermatan sulfate biosynthetic process	Reactome:R-HSA-2022923	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030207	chondroitin sulfate catabolic process	Reactome:R-HSA-2024101	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030206	chondroitin sulfate biosynthetic process	Reactome:R-HSA-2022870	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-4420365 Reactome:R-HSA-3636919 Reactome:R-HSA-3595178 Reactome:R-HSA-3595176 Reactome:R-HSA-3595175 Reactome:R-HSA-3560804 Reactome:R-HSA-3560802 Reactome:R-HSA-2022911 Reactome:R-HSA-2022065 Reactome:R-HSA-2022063 Reactome:R-HSA-2022061 Reactome:R-HSA-2022052 Reactome:R-HSA-2018682 Reactome:R-HSA-2018659 Reactome:R-HSA-1971491 Reactome:R-HSA-1971487 Reactome:R-HSA-1971483 Reactome:R-HSA-1971482 Reactome:R-HSA-1889981 Reactome:R-HSA-1889978 Reactome:R-HSA-1889955 Reactome:R-HSA-1878002	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-2424246 Reactome:R-HSA-2022911 Reactome:R-HSA-2022065 Reactome:R-HSA-2022056	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
enables	GO:0005540	hyaluronic acid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0373	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ ^4.0 ^4.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^5.0 ^5.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ ^8.0 ^8.1 Foster, LJ et al. (2005) Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23 1367-77 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 Ishihara, H et al. (2008) Endothelial cell barrier impairment induced by glioblastomas and transforming growth factor beta2 involves matrix metalloproteinases and tight junction proteins. J. Neuropathol. Exp. Neurol. 67 435-48 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Zimmermann, DR & Ruoslahti, E (1989) Multiple domains of the large fibroblast proteoglycan, versican. EMBO J. 8 2975-81 PubMed GONUTS page
↑ Naso, MF et al. (1994) Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. J. Biol. Chem. 269 32999-3008 PubMed GONUTS page

[PMID:28327460-1] 1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:20551380-2] 2.0 ^2.1 ^2.2 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:27559042-3] 3.0 ^3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:28675934-4] 4.0 ^4.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-5] 5.0 ^5.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:27068509-6] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:23658023-7] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:16210410-8] 8.0 ^8.1 Foster, LJ et al. (2005) Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23 1367-77 PubMed GONUTS page

[PMID:22261194-9] Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18431253-11] 11.0 ^11.1 Ishihara, H et al. (2008) Endothelial cell barrier impairment induced by glioblastomas and transforming growth factor beta2 involves matrix metalloproteinases and tight junction proteins. J. Neuropathol. Exp. Neurol. 67 435-48 PubMed GONUTS page

[PMID:2583089-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Zimmermann, DR & Ruoslahti, E (1989) Multiple domains of the large fibroblast proteoglycan, versican. EMBO J. 8 2975-81 PubMed GONUTS page

[PMID:7528742-13] Naso, MF et al. (1994) Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. J. Biol. Chem. 269 32999-3008 PubMed GONUTS page

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HUMAN:CSPG2

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Annotations

Notes

References

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