HUMAN:CP3A5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CYP3A5
Protein Name(s)	Cytochrome P450 3A5 CYPIIIA5 Cytochrome P450 HLp2 Cytochrome P450-PCN3
External Links
UniProt	P20815
EMBL	J04813 AK299002 AC005020 CH236956 CH471091 CH471091 BC033862 AF280107 L35912 S74699 S74700
CCDS	CCDS55134.1 CCDS5672.1
PIR	A34101 A60558
RefSeq	NP_000768.1 NP_001177413.1
UniGene	Hs.571258
PDB	5VEU
PDBsum	5VEU
ProteinModelPortal	P20815
SMR	P20815
BioGrid	107949
IntAct	P20815
STRING	9606.ENSP00000222982
BindingDB	P20815
ChEMBL	CHEMBL3019
DrugBank	DB00802 DB00404 DB06403 DB01118 DB00321 DB00381 DB00701 DB06605 DB00673 DB00278 DB01238 DB06413 DB06697 DB00637 DB01076 DB06626 DB00972 DB04957 DB00394 DB08873 DB08870 DB00921 DB00490 DB06772 DB00201 DB00564 DB00439 DB06419 DB00446 DB00608 DB01114 DB01166 DB00501 DB00537 DB00604 DB01211 DB00575 DB00758 DB05239 DB00907 DB00318 DB08865 DB00531 DB00091 DB09102 DB00250 DB01254 DB00694 DB00705 DB01234 DB04856 DB00514 DB00829 DB00343 DB00822 DB01248 DB08930 DB01184 DB01126 DB08899 DB00700 DB00530 DB00783 DB00655 DB00593 DB00773 DB01023 DB00813 DB01216 DB00196 DB00472 DB00499 DB00588 DB01095 DB00176 DB00317 DB06730 DB00889 DB01218 DB00502 DB00741 DB06789 DB09053 DB01181 DB04946 DB00619 DB00224 DB00762 DB01167 DB01026 DB01259 DB00528 DB01227 DB00281 DB00678 DB00227 DB00333 DB01388 DB00683 DB00834 DB00745 DB00688 DB00731 DB01149 DB00220 DB00238 DB00622 DB01115 DB00393 DB00401 DB01054 DB00717 DB01059 DB00540 DB00904 DB00842 DB00776 DB01062 DB00497 DB01229 DB01267 DB09297 DB00738 DB08883 DB00780 DB01174 DB00252 DB01100 DB08901 DB00175 DB01058 DB00396 DB00571 DB01224 DB01103 DB00468 DB00863 DB00206 DB01045 DB01201 DB00734 DB00503 DB06228 DB06176 DB01098 DB00938 DB01232 DB06335 DB06731 DB00203 DB00641 DB00877 DB00398 DB00795 DB01268 DB00864 DB00675 DB00976 DB06287 DB00444 DB00342 DB00624 DB01041 DB05773 DB00656 DB00755 DB00897 DB00197 DB01361 DB06267 DB00313 DB00862 DB00661 DB00541 DB00582 DB09068 DB00943 DB00962 DB00246 DB00425
GuidetoPHARMACOLOGY	1338
SwissLipids	SLP:000001325
iPTMnet	P20815
PhosphoSitePlus	P20815
BioMuta	CYP3A5
DMDM	117157
PaxDb	P20815
PeptideAtlas	P20815
PRIDE	P20815
DNASU	1577
Ensembl	ENST00000222982 ENST00000439761
GeneID	1577
KEGG	hsa:1577
UCSC	uc003urq.4
CTD	1577
DisGeNET	1577
EuPathDB	HostDB:ENSG00000106258.13
GeneCards	CYP3A5
HGNC	HGNC:2638
HPA	HPA072245
MalaCards	CYP3A5
MIM	605325
neXtProt	NX_P20815
OpenTargets	ENSG00000106258
Orphanet	241043
PharmGKB	PA131
eggNOG	KOG0158 COG2124
GeneTree	ENSGT00900000140779
HOGENOM	HOG000082412
HOVERGEN	HBG108567
InParanoid	P20815
KO	K17690
OMA	PAIAKHI
OrthoDB	EOG091G0JNC
PhylomeDB	P20815
TreeFam	TF105087
BRENDA	1.14.14.1
Reactome	R-HSA-211981 R-HSA-5423646
SABIO-RK	P20815
ChiTaRS	CYP3A5
GeneWiki	CYP3A5
GenomeRNAi	1577
PRO	PR:P20815
Proteomes	UP000005640
Bgee	ENSG00000106258
CleanEx	HS_CYP3A5
ExpressionAtlas	P20815
Genevisible	P20815
GO	GO:0005789 GO:0043231 GO:0031090 GO:0070330 GO:0101020 GO:0020037 GO:0005506 GO:0004497 GO:0016491 GO:0019825 GO:0009822 GO:0042737 GO:0002933 GO:0070989 GO:0008202 GO:0006805
Gene3D	1.10.630.10
InterPro	IPR001128 IPR017972 IPR008072 IPR002402 IPR036396
Pfam	PF00067
PRINTS	PR00464 PR01689 PR00385
SUPFAM	SSF48264
PROSITE	PS00086

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0002933	lipid hydroxylation	PMID:14559847^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0008202)	Seeded From UniProt	complete
enables	GO:0101020	estrogen 16-alpha-hydroxylase activity	PMID:14559847^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:17263) part_of:(GO:0002933) part_of:(GO:0008202)\|has_direct_input(CHEBI:16469) part_of:(GO:0002933) part_of:(GO:0008202)	Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	PMID:14559847^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070989	oxidative demethylation	PMID:15039299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042737	drug catabolic process	PMID:15039299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:15039299^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009822	alkaloid catabolic process	PMID:15039299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86SK3	F		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002402	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002402 InterPro:IPR008072 InterPro:IPR036396	F		Seeded From UniProt	complete
enables	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR017972 InterPro:IPR036396	F		Seeded From UniProt	complete
enables	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008072	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002402 InterPro:IPR008072 InterPro:IPR036396	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002402 InterPro:IPR008072 InterPro:IPR017972 InterPro:IPR036396	P		Seeded From UniProt	complete
enables	GO:0070330	aromatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.14.1	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:2732228^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019825	oxygen binding	PMID:2732228^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	PMID:2732228^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	PMID:2732228^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006805	xenobiotic metabolic process	Reactome:R-HSA-211981 Reactome:R-HSA-211859	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-5423664 Reactome:R-HSA-213175 Reactome:R-HSA-156526	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lee, AJ et al. (2003) Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res. 63 6532-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Lalovic, B et al. (2004) Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab. Dispos. 32 447-54 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Aoyama, T et al. (1989) Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J. Biol. Chem. 264 10388-95 PubMed GONUTS page

[PMID:14559847-1] 1.0 ^1.1 ^1.2 Lee, AJ et al. (2003) Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res. 63 6532-6 PubMed GONUTS page

[PMID:15039299-2] 2.0 ^2.1 ^2.2 ^2.3 Lalovic, B et al. (2004) Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab. Dispos. 32 447-54 PubMed GONUTS page

[PMID:2732228-3] 3.0 ^3.1 ^3.2 ^3.3 Aoyama, T et al. (1989) Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J. Biol. Chem. 264 10388-95 PubMed GONUTS page

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HUMAN:CP3A5

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