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HUMAN:CP2R1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CYP2R1
Protein Name(s) Vitamin D 25-hydroxylase

Cytochrome P450 2R1

External Links
UniProt Q6VVX0
EMBL AY323817
BC104907
BC104909
AY800276
CCDS CCDS7818.1
RefSeq NP_078790.2
UniGene Hs.371427
PDB 3C6G
3CZH
3DL9
PDBsum 3C6G
3CZH
3DL9
ProteinModelPortal Q6VVX0
SMR Q6VVX0
STRING 9606.ENSP00000334592
DrugBank DB00169
DB00153
DMDM 62286619
MaxQB Q6VVX0
PaxDb Q6VVX0
PRIDE Q6VVX0
Ensembl ENST00000334636
GeneID 120227
KEGG hsa:120227
UCSC uc001mlp.3
CTD 120227
GeneCards GC11M014856
HGNC HGNC:20580
HPA HPA042949
MIM 600081
608713
neXtProt NX_Q6VVX0
Orphanet 289157
PharmGKB PA134986407
eggNOG COG2124
GeneTree ENSGT00760000118775
HOGENOM HOG000036991
HOVERGEN HBG015789
InParanoid Q6VVX0
KO K07419
OMA IMGPNGK
PhylomeDB Q6VVX0
TreeFam TF352043
BioCyc MetaCyc:HS17721-MONOMER
Reactome REACT_13450
REACT_13523
SABIO-RK Q6VVX0
EvolutionaryTrace Q6VVX0
GeneWiki CYP2R1
GenomeRNAi 120227
NextBio 80549
PRO PR:Q6VVX0
Proteomes UP000005640
Bgee Q6VVX0
CleanEx HS_CYP2R1
ExpressionAtlas Q6VVX0
Genevestigator Q6VVX0
GO GO:0005789
GO:0020037
GO:0005506
GO:0004497
GO:0016705
GO:0030343
GO:0044281
GO:0008202
GO:0042359
GO:0006766
GO:0006805
Gene3D 1.10.630.10
InterPro IPR001128
IPR017972
IPR002401
Pfam PF00067
PRINTS PR00463
PR00385
SUPFAM SSF48264
PROSITE PS00086

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0036378

calcitriol biosynthetic process from calciol

PMID:15465040[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030343

vitamin D3 25-hydroxylase activity

PMID:15465040[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919332
MGI:MGI:2147497
MGI:MGI:3642960
PANTHER:PTN000670347
RGD:2475
UniProtKB:P05181
UniProtKB:P10632
UniProtKB:P10635
UniProtKB:P11712
UniProtKB:P20813
UniProtKB:P33261

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000670347
RGD:1306078
RGD:1311866
RGD:2463
RGD:2466
RGD:2467
RGD:2471
RGD:2475
RGD:620007
RGD:620370
RGD:620379
RGD:620640
RGD:628627
UniProtKB:P11712
UniProtKB:P24903
WB:WBGene00018334

C

Seeded From UniProt

complete

involved_in

GO:0042738

exogenous drug catabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000670347
UniProtKB:A0A087X1C5
UniProtKB:P10632
UniProtKB:P11509
UniProtKB:P11712
UniProtKB:P20813
UniProtKB:P33261

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000670347
UniProtKB:P05181
UniProtKB:P10635
UniProtKB:P11509
UniProtKB:P20813
UniProtKB:P33261
UniProtKB:Q16696

F

Seeded From UniProt

complete

enables

GO:0016712

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000670347
RGD:2475
UniProtKB:P24903

F

Seeded From UniProt

complete

enables

GO:0008395

steroid hydroxylase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010383
PANTHER:PTN001210788
RGD:2463
RGD:2464
RGD:2466
RGD:2467
UniProtKB:P11712
UniProtKB:P33261

F

Seeded From UniProt

complete

involved_in

GO:0006805

xenobiotic metabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000670347
RGD:2475
UniProtKB:A0A087X1C5
UniProtKB:P20813
UniProtKB:Q8TAV3

P

Seeded From UniProt

complete

involved_in

GO:0006082

organic acid metabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000670347
UniProtKB:P10632

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1929474
PANTHER:PTN000670347
RGD:708427
UniProtKB:A0A087X1C5
WB:WBGene00000905

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F7FAJ1
ensembl:ENSRNOP00000063152

C

Seeded From UniProt

complete

involved_in

GO:0010212

response to ionizing radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F7FAJ1
ensembl:ENSRNOP00000063152

P

Seeded From UniProt

complete

involved_in

GO:0010164

response to cesium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F7FAJ1
ensembl:ENSRNOP00000063152

P

Seeded From UniProt

complete

involved_in

GO:0010038

response to metal ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F7FAJ1
ensembl:ENSRNOP00000063152

P

Seeded From UniProt

complete

involved_in

GO:0042359

vitamin D metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VVW9
ensembl:ENSMUSP00000032908

P

Seeded From UniProt

complete

enables

GO:0030343

vitamin D3 25-hydroxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VVW9
ensembl:ENSMUSP00000032908

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR036396

F

Seeded From UniProt

complete

enables

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR017972
InterPro:IPR036396

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR036396

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR017972
InterPro:IPR036396

P

Seeded From UniProt

complete

involved_in

GO:0042359

vitamin D metabolic process

Reactome:R-HSA-196791

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030343

vitamin D3 25-hydroxylase activity

Reactome:R-HSA-209845

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006766

vitamin metabolic process

Reactome:R-HSA-211916

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

Reactome:R-HSA-209845

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0492

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

part_of

GO:0031090

organelle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0165

C

Seeded From UniProt

complete

involved_in

GO:0042368

vitamin D biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00954

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Shinkyo, R et al. (2004) Metabolism of vitamin D by human microsomal CYP2R1. Biochem. Biophys. Res. Commun. 324 451-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page