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HUMAN:CP2R1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CYP2R1 | |
| Protein Name(s) | Vitamin D 25-hydroxylase
Cytochrome P450 2R1 | |
| External Links | ||
| UniProt | Q6VVX0 | |
| EMBL | AY323817 BC104907 BC104909 AY800276 | |
| CCDS | CCDS7818.1 | |
| RefSeq | NP_078790.2 | |
| UniGene | Hs.371427 | |
| PDB | 3C6G 3CZH 3DL9 | |
| PDBsum | 3C6G 3CZH 3DL9 | |
| ProteinModelPortal | Q6VVX0 | |
| SMR | Q6VVX0 | |
| STRING | 9606.ENSP00000334592 | |
| DrugBank | DB00169 DB00153 | |
| DMDM | 62286619 | |
| MaxQB | Q6VVX0 | |
| PaxDb | Q6VVX0 | |
| PRIDE | Q6VVX0 | |
| Ensembl | ENST00000334636 | |
| GeneID | 120227 | |
| KEGG | hsa:120227 | |
| UCSC | uc001mlp.3 | |
| CTD | 120227 | |
| GeneCards | GC11M014856 | |
| HGNC | HGNC:20580 | |
| HPA | HPA042949 | |
| MIM | 600081 608713 | |
| neXtProt | NX_Q6VVX0 | |
| Orphanet | 289157 | |
| PharmGKB | PA134986407 | |
| eggNOG | COG2124 | |
| GeneTree | ENSGT00760000118775 | |
| HOGENOM | HOG000036991 | |
| HOVERGEN | HBG015789 | |
| InParanoid | Q6VVX0 | |
| KO | K07419 | |
| OMA | IMGPNGK | |
| PhylomeDB | Q6VVX0 | |
| TreeFam | TF352043 | |
| BioCyc | MetaCyc:HS17721-MONOMER | |
| Reactome | REACT_13450 REACT_13523 | |
| SABIO-RK | Q6VVX0 | |
| EvolutionaryTrace | Q6VVX0 | |
| GeneWiki | CYP2R1 | |
| GenomeRNAi | 120227 | |
| NextBio | 80549 | |
| PRO | PR:Q6VVX0 | |
| Proteomes | UP000005640 | |
| Bgee | Q6VVX0 | |
| CleanEx | HS_CYP2R1 | |
| ExpressionAtlas | Q6VVX0 | |
| Genevestigator | Q6VVX0 | |
| GO | GO:0005789 GO:0020037 GO:0005506 GO:0004497 GO:0016705 GO:0030343 GO:0044281 GO:0008202 GO:0042359 GO:0006766 GO:0006805 | |
| Gene3D | 1.10.630.10 | |
| InterPro | IPR001128 IPR017972 IPR002401 | |
| Pfam | PF00067 | |
| PRINTS | PR00463 PR00385 | |
| SUPFAM | SSF48264 | |
| PROSITE | PS00086 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0036378 |
calcitriol biosynthetic process from calciol |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030343 |
vitamin D3 25-hydroxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919332 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000670347 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042738 |
exogenous drug catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000670347 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0020037 |
heme binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000670347 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000670347 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008395 |
steroid hydroxylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010383 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000670347 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006082 |
organic acid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000670347 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1929474 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F7FAJ1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010212 |
response to ionizing radiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F7FAJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010164 |
response to cesium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F7FAJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010038 |
response to metal ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F7FAJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042359 |
vitamin D metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6VVW9 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030343 |
vitamin D3 25-hydroxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6VVW9 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001128 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0020037 |
heme binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001128 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042359 |
vitamin D metabolic process |
Reactome:R-HSA-196791 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030343 |
vitamin D3 25-hydroxylase activity |
Reactome:R-HSA-209845 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006766 |
vitamin metabolic process |
Reactome:R-HSA-211916 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-209845 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031090 |
organelle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042368 |
vitamin D biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00954 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shinkyo, R et al. (2004) Metabolism of vitamin D by human microsomal CYP2R1. Biochem. Biophys. Res. Commun. 324 451-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0055114 ! obsolete oxidation-reduction process
- GO:0031090 ! organelle membrane
- GO:0006082 ! organic acid metabolic process
- GO:0016491 ! oxidoreductase activity
- GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
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