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HUMAN:CP19A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CYP19A1 (synonyms: ARO1, CYAR, CYP19) | |
| Protein Name(s) | Aromatase
CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase | |
| External Links | ||
| UniProt | P11511 | |
| EMBL | M22246 X13589 M18856 J04127 Y07508 M30804 M30796 M30797 M30798 M30800 M30801 M30802 M30803 AY957953 AC012169 AC020891 BC035714 BC107785 M28420 | |
| CCDS | CCDS10139.1 | |
| PIR | A34451 | |
| RefSeq | NP_000094.2 NP_112503.1 XP_005254247.1 XP_005254248.1 | |
| UniGene | Hs.260074 | |
| PDB | 1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8 | |
| PDBsum | 1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8 | |
| ProteinModelPortal | P11511 | |
| SMR | P11511 | |
| IntAct | P11511 | |
| MINT | MINT-4054553 | |
| STRING | 9606.ENSP00000260433 | |
| BindingDB | P11511 | |
| ChEMBL | CHEMBL1978 | |
| DrugBank | DB00357 DB01217 DB00443 DB04794 DB06719 DB00389 DB00856 DB00882 DB00257 DB04839 DB01406 DB01234 DB00255 DB00917 DB00858 DB01127 DB00974 DB00292 DB00990 DB01026 DB01006 DB01227 DB00367 DB00358 DB01065 DB00333 DB06710 DB01110 DB08804 DB00984 DB00184 DB01229 DB00481 DB06147 DB00675 DB00857 DB00894 DB00624 DB01007 DB00072 | |
| GuidetoPHARMACOLOGY | 1362 | |
| PhosphoSite | P11511 | |
| DMDM | 117293 | |
| PaxDb | P11511 | |
| PRIDE | P11511 | |
| DNASU | 1588 | |
| Ensembl | ENST00000260433 ENST00000396402 ENST00000396404 ENST00000405913 ENST00000557858 ENST00000559878 | |
| GeneID | 1588 | |
| KEGG | hsa:1588 | |
| UCSC | uc001zyz.4 uc001zzd.3 | |
| CTD | 1588 | |
| GeneCards | GC15M051500 | |
| HGNC | HGNC:2594 | |
| HPA | CAB000355 HPA051194 | |
| MIM | 107910 139300 613546 | |
| neXtProt | NX_P11511 | |
| Orphanet | 91 178345 | |
| PharmGKB | PA27091 | |
| eggNOG | COG2124 | |
| GeneTree | ENSGT00760000119376 | |
| HOGENOM | HOG000111912 | |
| HOVERGEN | HBG050750 | |
| InParanoid | P11511 | |
| KO | K07434 | |
| OMA | NFAKNVP | |
| OrthoDB | EOG7D85W5 | |
| PhylomeDB | P11511 | |
| TreeFam | TF352039 | |
| BioCyc | MetaCyc:HS06413-MONOMER | |
| Reactome | REACT_11037 REACT_13812 | |
| SABIO-RK | P11511 | |
| ChiTaRS | CYP19A1 | |
| EvolutionaryTrace | P11511 | |
| GeneWiki | Aromatase | |
| GenomeRNAi | 1588 | |
| NextBio | 6526 | |
| PRO | PR:P11511 | |
| Proteomes | UP000005640 | |
| Bgee | P11511 | |
| CleanEx | HS_CYP19A1 | |
| ExpressionAtlas | P11511 | |
| Genevestigator | P11511 | |
| GO | GO:0005783 GO:0005789 GO:0016020 GO:0070330 GO:0009055 GO:0020037 GO:0005506 GO:0016712 GO:0019825 GO:0008209 GO:0006703 GO:0060736 GO:0044281 GO:0006694 GO:0008202 GO:0016125 GO:0006805 | |
| Gene3D | 1.10.630.10 | |
| InterPro | IPR001128 IPR017972 IPR002401 | |
| Pfam | PF00067 | |
| PRINTS | PR00463 PR00385 | |
| SUPFAM | SSF48264 | |
| PROSITE | PS00086 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006710 |
androgen catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070330 |
aromatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000866 |
positive regulation of estradiol secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070330 |
aromatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0020037 |
heme binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022900 |
electron transport chain |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0009055 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061370 |
testosterone biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060736 |
prostate gland growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060065 |
uterus development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030879 |
mammary gland development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030540 |
female genitalia development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010760 |
negative regulation of macrophage chemotaxis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008585 |
female gonad development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008209 |
androgen metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002677 |
negative regulation of chronic inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28649 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001128 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0020037 |
heme binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001128 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019825 |
oxygen binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006694 |
steroid biosynthetic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009055 |
electron transfer activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016125 |
sterol metabolic process |
Reactome:R-HSA-211976 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008395 |
steroid hydroxylase activity |
Reactome:R-HSA-193143 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006703 |
estrogen biosynthetic process |
Reactome:R-HSA-193144 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-193143 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Leitner, L et al. (2015) Osteopontin promotes aromatase expression and estradiol production in human adipocytes. Breast Cancer Res. Treat. 154 63-9 PubMed GONUTS page
- ↑ 2.0 2.1 Ghosh, D et al. (2009) Structural basis for androgen specificity and oestrogen synthesis in human aromatase. Nature 457 219-23 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Corbin, CJ et al. (1988) Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc. Natl. Acad. Sci. U.S.A. 85 8948-52 PubMed GONUTS page
- ↑ Harada, N et al. (1992) Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency. J. Biol. Chem. 267 4781-5 PubMed GONUTS page
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- GO:0055114 ! obsolete oxidation-reduction process
- GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- GO:0016491 ! oxidoreductase activity
- GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- GO:0019825 ! oxygen binding
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