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HUMAN:COX18
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | COX18 (synonyms: OXA1L2) | |
| Protein Name(s) | Mitochondrial inner membrane protein COX18
COX18Hs Cytochrome c oxidase assembly protein 18 | |
| External Links | ||
| UniProt | Q8N8Q8 | |
| EMBL | AY957564 AY957565 AK096310 BC071812 BC101684 AM055750 AM055751 AM055752 | |
| CCDS | CCDS3554.1 | |
| RefSeq | NP_001284662.1 NP_001287658.1 NP_776188.1 | |
| UniGene | Hs.356697 | |
| ProteinModelPortal | Q8N8Q8 | |
| SMR | Q8N8Q8 | |
| BioGrid | 130132 | |
| STRING | 9606.ENSP00000295890 | |
| PhosphoSite | Q8N8Q8 | |
| DMDM | 38372495 | |
| MaxQB | Q8N8Q8 | |
| PaxDb | Q8N8Q8 | |
| PRIDE | Q8N8Q8 | |
| Ensembl | ENST00000295890 ENST00000449739 ENST00000510031 | |
| GeneID | 285521 | |
| KEGG | hsa:285521 | |
| UCSC | uc003hgm.1 | |
| CTD | 285521 | |
| GeneCards | GC04M073920 | |
| HGNC | HGNC:26801 | |
| HPA | HPA046772 HPA049489 | |
| MIM | 610428 | |
| neXtProt | NX_Q8N8Q8 | |
| PharmGKB | PA145008543 | |
| eggNOG | COG0706 | |
| GeneTree | ENSGT00530000063506 | |
| HOVERGEN | HBG081304 | |
| InParanoid | Q8N8Q8 | |
| KO | K17797 | |
| OrthoDB | EOG7S4X6H | |
| PhylomeDB | Q8N8Q8 | |
| TreeFam | TF323948 | |
| Reactome | REACT_22393 REACT_267716 | |
| GenomeRNAi | 285521 | |
| NextBio | 95575 | |
| PRO | PR:Q8N8Q8 | |
| Proteomes | UP000005640 | |
| Bgee | Q8N8Q8 | |
| CleanEx | HS_COX18 | |
| ExpressionAtlas | Q8N8Q8 | |
| Genevestigator | Q8N8Q8 | |
| GO | GO:0031305 GO:0008565 GO:0051204 GO:0015031 GO:0008535 | |
| InterPro | IPR001708 | |
| PANTHER | PTHR12428 | |
| Pfam | PF02096 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0032977 |
membrane insertase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033617 |
mitochondrial respiratory chain complex IV assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032979 |
protein insertion into mitochondrial inner membrane from matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051204 |
protein insertion into mitochondrial membrane |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031305 |
integral component of mitochondrial inner membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032977 |
membrane insertase activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008535 |
respiratory chain complex IV assembly |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051205 |
protein insertion into membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11197 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033617 |
mitochondrial respiratory chain complex IV assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000276806 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032979 |
protein insertion into mitochondrial inner membrane from matrix |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000276806 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0032977 |
membrane insertase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11197 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031305 |
integral component of mitochondrial inner membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000276806 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032977 |
membrane insertase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Bourens, M & Barrientos, A (2017) Human mitochondrial cytochrome oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module. J. Biol. Chem. 292 7774-7783 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaisne, M & Bonnefoy, N (2006) The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast. FEMS Yeast Res. 6 869-82 PubMed GONUTS page
- ↑ Sacconi, S et al. (2005) hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly. Biochem. Biophys. Res. Commun. 337 832-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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