HUMAN:CNTN2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CNTN2 (synonyms: AXT, TAG1, TAX1)
Protein Name(s)	Contactin-2 Axonal glycoprotein TAG-1 Axonin-1 Transient axonal glycoprotein 1 TAX-1
External Links
UniProt	Q02246
EMBL	X68274 X67734 X84420 AL583832 X92681
CCDS	CCDS1449.1
PIR	S35508
RefSeq	NP_005067.1
UniGene	Hs.519220
PDB	2OM5
PDBsum	2OM5
ProteinModelPortal	Q02246
SMR	Q02246
BioGrid	112763
IntAct	Q02246
MINT	MINT-2805397
STRING	9606.ENSP00000330633
TCDB	8.A.23.1.3
PhosphoSite	Q02246
DMDM	399092
PaxDb	Q02246
PRIDE	Q02246
Ensembl	ENST00000331830
GeneID	6900
KEGG	hsa:6900
UCSC	uc001hbq.1
CTD	6900
GeneCards	GC01P205012
HGNC	HGNC:2172
HPA	HPA001397 HPA012497
MIM	190197 615400
neXtProt	NX_Q02246
Orphanet	86814
PharmGKB	PA26686
eggNOG	NOG293951
GeneTree	ENSGT00760000118840
HOGENOM	HOG000059617
HOVERGEN	HBG051047
InParanoid	Q02246
KO	K06760
OMA	ECFAFGN
OrthoDB	EOG7J17Z5
PhylomeDB	Q02246
TreeFam	TF351103
Reactome	REACT_18312 REACT_22205 REACT_22329
ChiTaRS	CNTN2
EvolutionaryTrace	Q02246
GeneWiki	CNTN2
GenomeRNAi	6900
NextBio	26975
PRO	PR:Q02246
Proteomes	UP000005640
Bgee	Q02246
CleanEx	HS_CNTN2
ExpressionAtlas	Q02246
Genevestigator	Q02246
GO	GO:0031225 GO:0009986 GO:0005887 GO:0044224 GO:0043209 GO:0043025 GO:0033268 GO:0005886 GO:0045202 GO:0008076 GO:0030246 GO:0042802 GO:0007628 GO:0007411 GO:0007413 GO:0007155 GO:0034613 GO:0022010 GO:0021853 GO:0045163 GO:0071206 GO:0007612 GO:0000226 GO:0045665 GO:0060168 GO:0010954 GO:0097090 GO:0031623 GO:0048710 GO:0031133 GO:0048168
Gene3D	2.60.40.10
InterPro	IPR003961 IPR007110 IPR013783 IPR013098 IPR003599 IPR003598
Pfam	PF00041 PF07679
SMART	SM00060 SM00409 SM00408
SUPFAM	SSF49265
PROSITE	PS50853 PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007155	cell adhesion	PMID:8425542^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22063	C		Seeded From UniProt	complete
involved_in	GO:0045163	clustering of voltage-gated potassium channels	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61330	P		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61330	C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61330	C		Seeded From UniProt	complete
involved_in	GO:0071205	protein localization to juxtaparanode region of axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61330	P		Seeded From UniProt	complete
part_of	GO:0033268	node of Ranvier	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61330	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22063	C		Seeded From UniProt	complete
involved_in	GO:0097090	presynaptic membrane organization	PMID:23518707^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099025	anchored component of postsynaptic membrane	PMID:26217189^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099025	anchored component of postsynaptic membrane	PMID:26217189^[3]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099025	anchored component of postsynaptic membrane	PMID:26217189^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098632	cell-cell adhesion mediator activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010473 FB:FBgn0028482 PANTHER:PTN001296633	F		Seeded From UniProt	complete
involved_in	GO:0070593	dendrite self-avoidance	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010473 MGI:MGI:1196281 MGI:MGI:2150309 PANTHER:PTN001296633 UniProtKB:A0A0B4K823	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104750 MGI:MGI:1196281 PANTHER:PTN001296633 RGD:2322545 UniProtKB:A0A0B4K823 UniProtKB:Q03696 WB:WBGene00004370 WB:WBGene00016354	C		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010473 MGI:MGI:104750 PANTHER:PTN001296633 UniProtKB:A0A0B4K823	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000635 FB:FBgn0028482 FB:FBgn0265296 PANTHER:PTN001296633 RGD:620296 UniProtKB:Q8TD84	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000635 MGI:MGI:104750 MGI:MGI:1196281 MGI:MGI:1858223 MGI:MGI:2444710 PANTHER:PTN001296633 UniProtKB:P35613 UniProtKB:Q8WX93	C		Seeded From UniProt	complete
involved_in	GO:0071206	establishment of protein localization to juxtaparanode region of axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0071205	protein localization to juxtaparanode region of axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0060168	positive regulation of adenosine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0048710	regulation of astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0045163	clustering of voltage-gated potassium channels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	F		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
part_of	GO:0033268	node of Ranvier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0031133	regulation of axon diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	F		Seeded From UniProt	complete
involved_in	GO:0022010	central nervous system myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0021853	cerebral cortex GABAergic interneuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0010954	positive regulation of protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0010769	regulation of cell morphogenesis involved in differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	C		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0007413	axonal fasciculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61330 ensembl:ENSMUSP00000083707	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032991	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032991	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8425542^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12963709^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hasler, TH et al. (1993) cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1. Eur. J. Biochem. 211 329-39 PubMed GONUTS page
↑ Stogmann, E et al. (2013) Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2. Brain 136 1155-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Pinatel, D et al. (2015) Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis. Front Cell Neurosci 9 265 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Poliak, S et al. (2003) Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J. Cell Biol. 162 1149-60 PubMed GONUTS page

[PMID:8425542-1] 1.0 ^1.1 Hasler, TH et al. (1993) cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1. Eur. J. Biochem. 211 329-39 PubMed GONUTS page

[PMID:23518707-2] Stogmann, E et al. (2013) Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2. Brain 136 1155-60 PubMed GONUTS page

[PMID:26217189-3] 3.0 ^3.1 ^3.2 Pinatel, D et al. (2015) Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis. Front Cell Neurosci 9 265 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12963709-5] Poliak, S et al. (2003) Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J. Cell Biol. 162 1149-60 PubMed GONUTS page

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HUMAN:CNTN2

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Annotations

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References

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