HUMAN:CNTFR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CNTFR
Protein Name(s)	Ciliary neurotrophic factor receptor subunit alpha CNTF receptor subunit alpha CNTFR-alpha
External Links
UniProt	P26992
EMBL	M73238 L38025 L38022 L38023 L38024 BT019824 AL160270 CH471071 CH471071 CH471071 CH471071 BC001492
CCDS	CCDS6558.1
PIR	A40854
RefSeq	NP_001193940.1 NP_001833.1 NP_671693.1 XP_005251419.1 XP_005251420.1
UniGene	Hs.129966
PDB	1UC6
PDBsum	1UC6
ProteinModelPortal	P26992
SMR	P26992
BioGrid	107671
DIP	DIP-5777N
IntAct	P26992
STRING	9606.ENSP00000242338
DMDM	1352099
PaxDb	P26992
PRIDE	P26992
DNASU	1271
Ensembl	ENST00000351266 ENST00000378980 ENST00000610543
GeneID	1271
KEGG	hsa:1271
UCSC	uc003zup.2
CTD	1271
GeneCards	GC09M034541
HGNC	HGNC:2170
HPA	CAB025310
MIM	118946
neXtProt	NX_P26992
PharmGKB	PA26684
eggNOG	NOG42607
GeneTree	ENSGT00530000063103
HOGENOM	HOG000171060
HOVERGEN	HBG051048
InParanoid	P26992
KO	K05059
OMA	QETPHVQ
OrthoDB	EOG72NRQF
PhylomeDB	P26992
TreeFam	TF331210
SignaLink	P26992
ChiTaRS	CNTFR
EvolutionaryTrace	P26992
GenomeRNAi	1271
NextBio	5147
PRO	PR:P26992
Proteomes	UP000005640
Bgee	P26992
CleanEx	HS_CNTFR
ExpressionAtlas	P26992
Genevestigator	P26992
GO	GO:0031225 GO:0070110 GO:0097059 GO:0019898 GO:0004897 GO:0019955 GO:0005102 GO:0003360 GO:0070120 GO:0043524 GO:0007399 GO:0008284 GO:0007548 GO:0007165 GO:0060538 GO:0001967
Gene3D	2.60.40.10
InterPro	IPR003961 IPR003530 IPR007110 IPR013783 IPR003598
Pfam	PF00041
SMART	SM00060 SM00408
SUPFAM	SSF49265
PROSITE	PS50853 PS01354 PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0016324	apical plasma membrane	PMID:21912637^[1]	ECO:0000314			C	Figure 5 - CNTFR normally in the apical membrane.	complete CACAO 7574
part_of	GO:0016324	apical plasma membrane	PMID:21912637^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070110	ciliary neurotrophic factor receptor complex	PMID:12643274^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:1648265^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0097059	CNTFR-CLCF1 complex	PMID:11285233^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	PMID:12643274^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12707266^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42702	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12707266^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40189	F	Seeded From UniProt	complete
contributes_to	GO:0004897	ciliary neurotrophic factor receptor activity	PMID:12643274^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:15272019^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UBD9	F	Seeded From UniProt	complete
part_of	GO:0097059	CNTFR-CLCF1 complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001495218 UniProtKB:P26992	C	Seeded From UniProt	complete
part_of	GO:0070110	ciliary neurotrophic factor receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001495218 UniProtKB:P26992	C	Seeded From UniProt	complete
enables	GO:0045523	interleukin-27 receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354171 PANTHER:PTN001495218	F	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002745476 UniProtKB:P10912 UniProtKB:P42702 UniProtKB:P48357 UniProtKB:Q5VWK5	C	Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104579 MGI:MGI:1330819 MGI:MGI:2180511 PANTHER:PTN002745476 RGD:1303100 RGD:621431 UniProtKB:O75462 UniProtKB:P26992	F	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104579 MGI:MGI:1270861 MGI:MGI:1330819 MGI:MGI:1889506 MGI:MGI:2180511 MGI:MGI:96551 MGI:MGI:96560 PANTHER:PTN002745476	C	Seeded From UniProt	complete
contributes_to	GO:0004897	ciliary neurotrophic factor receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99605 PANTHER:PTN001495218 RGD:1303100 UniProtKB:P26992	F	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002745476 UniProtKB:Q14213 UniProtKB:Q9HC73	F	Seeded From UniProt	complete
involved_in	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	P	Seeded From UniProt	complete
involved_in	GO:0060538	skeletal muscle organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	P	Seeded From UniProt	complete
involved_in	GO:0007548	sex differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	P	Seeded From UniProt	complete
enables	GO:0004897	ciliary neurotrophic factor receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	F	Seeded From UniProt	complete
involved_in	GO:0003360	brainstem development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	P	Seeded From UniProt	complete
involved_in	GO:0001967	suckling behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88507 ensembl:ENSMUSP00000100026	P	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003530	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003530	C	Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	PMID:1648265^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:7585948^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004897	ciliary neurotrophic factor receptor activity	PMID:7585948^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6783589	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6783556 Reactome:R-HSA-6783530 Reactome:R-HSA-5696491 Reactome:R-HSA-5696490	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Schuster, B et al. (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 9528-35 PubMed GONUTS page
↑ ^3.0 ^3.1 Davis, S et al. (1991) The receptor for ciliary neurotrophic factor. Science 253 59-63 PubMed GONUTS page
↑ Plun-Favreau, H et al. (2001) The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J. 20 1692-703 PubMed GONUTS page
↑ ^5.0 ^5.1 Man, D et al. (2003) Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. J. Biol. Chem. 278 23285-94 PubMed GONUTS page
↑ Perret, D et al. (2004) Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. J. Biol. Chem. 279 43961-70 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 DeChiara, TM et al. (1995) Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83 313-22 PubMed GONUTS page

[PMID:21912637-1] 1.0 ^1.1 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page

[PMID:12643274-2] 2.0 ^2.1 ^2.2 Schuster, B et al. (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 9528-35 PubMed GONUTS page

[PMID:1648265-3] 3.0 ^3.1 Davis, S et al. (1991) The receptor for ciliary neurotrophic factor. Science 253 59-63 PubMed GONUTS page

[PMID:11285233-4] Plun-Favreau, H et al. (2001) The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J. 20 1692-703 PubMed GONUTS page

[PMID:12707266-5] 5.0 ^5.1 Man, D et al. (2003) Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. J. Biol. Chem. 278 23285-94 PubMed GONUTS page

[PMID:15272019-6] Perret, D et al. (2004) Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. J. Biol. Chem. 279 43961-70 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7585948-8] 8.0 ^8.1 DeChiara, TM et al. (1995) Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83 313-22 PubMed GONUTS page

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HUMAN:CNTFR

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