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HUMAN:CNTF
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CNTF | |
| Protein Name(s) | Ciliary neurotrophic factor
CNTF | |
| External Links | ||
| UniProt | P26441 | |
| EMBL | X60542 X60477 X60478 X55889 X55890 AK314118 CH471076 BC068030 BC074963 BC074964 | |
| CCDS | CCDS31554.1 | |
| PIR | JH0455 | |
| RefSeq | NP_000605.1 | |
| UniGene | Hs.524920 | |
| PDB | 1CNT | |
| PDBsum | 1CNT | |
| ProteinModelPortal | P26441 | |
| SMR | P26441 | |
| BioGrid | 107670 | |
| DIP | DIP-5776N | |
| MINT | MINT-205057 | |
| STRING | 9606.ENSP00000355370 | |
| PhosphoSite | P26441 | |
| PaxDb | P26441 | |
| PRIDE | P26441 | |
| Ensembl | ENST00000361987 | |
| GeneID | 1270 | |
| KEGG | hsa:1270 | |
| UCSC | uc001nna.4 | |
| CTD | 1270 | |
| GeneCards | GC11P058390 | |
| HGNC | HGNC:2169 | |
| HPA | HPA019654 | |
| MIM | 118945 | |
| neXtProt | NX_P26441 | |
| PharmGKB | PA26683 | |
| eggNOG | NOG114783 | |
| GeneTree | ENSGT00420000029890 | |
| HOGENOM | HOG000059605 | |
| HOVERGEN | HBG005362 | |
| InParanoid | P26441 | |
| KO | K05420 | |
| OMA | KLWGLKV | |
| OrthoDB | EOG700893 | |
| PhylomeDB | P26441 | |
| TreeFam | TF336237 | |
| SignaLink | P26441 | |
| EvolutionaryTrace | P26441 | |
| GeneWiki | Ciliary_neurotrophic_factor | |
| GenomeRNAi | 1270 | |
| NextBio | 5143 | |
| PRO | PR:P26441 | |
| Proteomes | UP000005640 | |
| Bgee | P26441 | |
| CleanEx | HS_CNTF | |
| Genevestigator | P26441 | |
| GO | GO:0005737 GO:0005615 GO:0005127 GO:0008083 GO:0005138 GO:0070120 GO:0040007 GO:0048644 GO:0043524 GO:0046533 GO:0048666 GO:0008284 GO:0042517 GO:0046668 GO:0007165 | |
| Gene3D | 1.20.1250.10 | |
| InterPro | IPR009079 IPR012351 IPR000151 | |
| Pfam | PF01110 | |
| SUPFAM | SSF47266 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003406 |
retinal pigment epithelium development |
ECO:0000314 |
P |
Figure 4 - states Constitutive expression of CNTF in human RPE. |
complete | |||||
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Figure 6 - shows CNTF positive regulation of STAT3 phosphorylation. |
complete | |||||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
GO:0097058 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070120 |
ciliary neurotrophic factor-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000305 |
curator inference used in manual assertion |
GO:0008083 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005138 |
interleukin-6 receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070120 |
ciliary neurotrophic factor-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048680 |
positive regulation of axon regeneration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048143 |
astrocyte activation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88439 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88439 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88439 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005127 |
ciliary neurotrophic factor receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001432742 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048666 |
neuron development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51642 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048644 |
muscle organ morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51642 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046668 |
regulation of retinal cell programmed cell death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51642 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046533 |
negative regulation of photoreceptor cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51642 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51642 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51642 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51642 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005127 |
ciliary neurotrophic factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070120 |
ciliary neurotrophic factor-mediated signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005127 |
ciliary neurotrophic factor receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6783589 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6783556 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page
- ↑ Lam, A et al. (1991) Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 102 271-6 PubMed GONUTS page
- ↑ 3.0 3.1 Elson, GC et al. (2000) CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat. Neurosci. 3 867-72 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Schuster, B et al. (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 9528-35 PubMed GONUTS page
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Qin, S et al. (2013) Cross-talk between KLF4 and STAT3 regulates axon regeneration. Nat Commun 4 2633 PubMed GONUTS page
- ↑ Bazan, JF (1991) Neuropoietic cytokines in the hematopoietic fold. Neuron 7 197-208 PubMed GONUTS page
c
- Catarrhini
- GO:0030154 ! cell differentiation
- Chordata
- GO:0070120 ! ciliary neurotrophic factor-mediated signaling pathway
- GO:0005127 ! ciliary neurotrophic factor receptor binding
- Craniata
- GO:0097058 ! CRLF-CLCF1 complex
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0005125 ! cytokine activity
- GO:0005737 ! cytoplasm
e
m
n
p
- GO:0042517 ! positive regulation of tyrosine phosphorylation of Stat3 protein
- GO:0010628 ! positive regulation of gene expression
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0048680 ! positive regulation of axon regeneration
- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- Primates
- GO:0044877 ! protein-containing complex binding
r
