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HUMAN:CNR2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CNR2 (synonyms: CB2A, CB2B) | |
| Protein Name(s) | Cannabinoid receptor 2
CB-2 CB2 hCB2 CX5 | |
| External Links | ||
| UniProt | P34972 | |
| EMBL | X74328 EU517121 AJ430063 AJ430064 AY242132 AM156854 AM156855 AM156856 AL590609 CH471134 BC069722 BC074767 BC095545 | |
| CCDS | CCDS245.1 | |
| PIR | S36750 | |
| RefSeq | NP_001832.1 XP_005245793.1 XP_005245794.1 XP_005245795.1 | |
| UniGene | Hs.73037 | |
| PDB | 2KI9 | |
| PDBsum | 2KI9 | |
| ProteinModelPortal | P34972 | |
| SMR | P34972 | |
| IntAct | P34972 | |
| STRING | 9606.ENSP00000363596 | |
| BindingDB | P34972 | |
| ChEMBL | CHEMBL253 | |
| DrugBank | DB00470 DB00486 | |
| GuidetoPHARMACOLOGY | 57 | |
| PhosphoSite | P34972 | |
| DMDM | 461697 | |
| MaxQB | P34972 | |
| PaxDb | P34972 | |
| PRIDE | P34972 | |
| DNASU | 1269 | |
| Ensembl | ENST00000374472 | |
| GeneID | 1269 | |
| KEGG | hsa:1269 | |
| UCSC | uc001bif.3 | |
| CTD | 1269 | |
| GeneCards | GC01M024197 | |
| H-InvDB | HIX0160038 | |
| HGNC | HGNC:2160 | |
| HPA | CAB009719 HPA028718 | |
| MIM | 605051 | |
| neXtProt | NX_P34972 | |
| PharmGKB | PA26682 | |
| eggNOG | NOG276403 | |
| GeneTree | ENSGT00760000118804 | |
| HOGENOM | HOG000049272 | |
| HOVERGEN | HBG051045 | |
| InParanoid | P34972 | |
| KO | K04278 | |
| OMA | VNFHVFH | |
| OrthoDB | EOG7CK36K | |
| PhylomeDB | P34972 | |
| TreeFam | TF330052 | |
| Reactome | REACT_14828 REACT_19231 | |
| EvolutionaryTrace | P34972 | |
| GeneWiki | Cannabinoid_receptor_type_2 | |
| GenomeRNAi | 1269 | |
| NextBio | 5139 | |
| PRO | PR:P34972 | |
| Proteomes | UP000005640 | |
| Bgee | P34972 | |
| CleanEx | HS_CNR2 | |
| ExpressionAtlas | P34972 | |
| Genevestigator | P34972 | |
| GO | GO:0030425 GO:0031234 GO:0005887 GO:0043204 GO:0005886 GO:0004949 GO:0038171 GO:0007187 GO:0006955 GO:0006954 GO:0045759 GO:0050728 GO:0033004 GO:0051001 GO:0032229 GO:0001975 GO:0032496 GO:0019233 | |
| InterPro | IPR001551 IPR002230 IPR000276 IPR017452 | |
| PANTHER | PTHR22750:SF11 | |
| Pfam | PF00001 | |
| PRINTS | PR00523 PR00362 PR00237 | |
| PROSITE | PS00237 PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0038171 |
cannabinoid signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004949 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038171 |
cannabinoid signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004949 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038171 |
cannabinoid signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004949 |
P |
Seeded From UniProt |
complete | ||
| GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
C |
HUMAN CNR2 (CB2) // “Extensive co-localization of fluorescent images was observed when dual staining for ER and CB2 was carried out in cells from the 293 T/CB2-GFP line and imaged by confocal microscopy. An identical pattern of co-localization was also observed between the CB2 receptor and ER staining, but not CB2 and mitochondrial staining, in the SUDHL-4 cell line (data not shown).” (Fig 5C). |
complete | |||||
|
involved_in |
GO:0030595 |
leukocyte chemotaxis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47936 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051001 |
negative regulation of nitric-oxide synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045759 |
negative regulation of action potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033004 |
negative regulation of mast cell activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032229 |
negative regulation of synaptic transmission, GABAergic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019233 |
sensory perception of pain |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004949 |
cannabinoid receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001975 |
response to amphetamine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QZN9 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004949 |
cannabinoid receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007187 |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
PMID:8679694[2] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0004949 |
cannabinoid receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Castaneda, JT et al. (2017) Regulation of Cell Surface CB2 Receptor during Human B Cell Activation and Differentiation. J Neuroimmune Pharmacol PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Shire, D et al. (1996) Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim. Biophys. Acta 1307 132-6 PubMed GONUTS page
- ↑ Galiègue, S et al. (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. 232 54-61 PubMed GONUTS page
c
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g
i
n
- GO:0033004 ! negative regulation of mast cell activation
- GO:0045759 ! negative regulation of action potential
- GO:0051001 ! negative regulation of nitric-oxide synthase activity
- GO:0032229 ! negative regulation of synaptic transmission, GABAergic
- GO:0050728 ! negative regulation of inflammatory response
- GO:0043025 ! neuronal cell body
- GO:0043005 ! neuron projection
