HUMAN:CISD3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CISD3
Protein Name(s)	CDGSH iron-sulfur domain-containing protein 3, mitochondrial MitoNEET-related protein 2 Miner2
External Links
UniProt	P0C7P0
EMBL	AC006449 BM546511
CCDS	CCDS45662.1
RefSeq	NP_001129970.1
UniGene	Hs.713595
ProteinModelPortal	P0C7P0
SMR	P0C7P0
BioGrid	129759
STRING	9606.ENSP00000391402
PhosphoSite	P0C7P0
DMDM	190358744
MaxQB	P0C7P0
PaxDb	P0C7P0
PRIDE	P0C7P0
Ensembl	ENST00000613478 ENST00000620783
GeneID	284106
KEGG	hsa:284106
UCSC	uc010wds.1
CTD	284106
GeneCards	GC17P036886
H-InvDB	HIX0202460
HGNC	HGNC:27578
HPA	HPA053436 HPA054400
MIM	611933
neXtProt	NX_P0C7P0
PharmGKB	PA162382311
eggNOG	NOG87526
GeneTree	ENSGT00390000004574
HOGENOM	HOG000060282
HOVERGEN	HBG107689
InParanoid	P0C7P0
OMA	THKSERV
OrthoDB	EOG71RXND
PhylomeDB	P0C7P0
TreeFam	TF313111
GenomeRNAi	284106
NextBio	94542
PRO	PR:P0C7P0
Proteomes	UP000005640 UP000005640
Bgee	P0C7P0
CleanEx	HS_CISD3
Genevestigator	P0C7P0
GO	GO:0005739 GO:0051537 GO:0046872
InterPro	IPR018967 IPR006622
Pfam	PF09360
SMART	SM00704

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005739	mitochondrion	PMID:17376863	ECO:0000314			C		mito-NEET is suited to communicate signals between the mitochondria and the rest of the cell as seen in Figure 3. It is characterized by a CDGSH-type zinc finger domain(Figure 1), even though it does not contain any zinc. It is more likely iron containing (Table 1). This protein plays a role in regulating the ETC and oxidative phosphorylation (Figure 5). Yet it's actual role in the etiology of type 2 diabetes and mediating some of the insulin sensitizing thiazolidinediene drugs is yet to be determined.	complete
part_of	GO:0005739	mitochondrion	PMID:17376863	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	PMID:29259115	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051537	2 iron, 2 sulfur cluster binding	PMID:29259115	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0106034	protein maturation by [2Fe-2S] cluster transfer	PMID:29259115	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10109) has_input:(UniProtKB:Q6P4F2)	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018967	C		Seeded From UniProt	complete
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018967	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0001	F		Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F		Seeded From UniProt	complete
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References

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