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HUMAN:CIKS

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRAF3IP2 (synonyms: C6orf2, C6orf4, C6orf5, C6orf6)
Protein Name(s) Adapter protein CIKS

Connection to IKK and SAPK/JNK Nuclear factor NF-kappa-B activator 1 ACT1 TRAF3-interacting protein 2

External Links
UniProt O43734
EMBL AF136405
AF136406
AF136407
AF274303
AF272151
AK025351
AK026602
AK314415
AL050289
AL008730
AL008730
AL008730
AL008730
Z97989
Z97989
AL008730
Z97989
AL008730
CH471051
CH471051
BC002823
BI856094
CCDS CCDS5093.1
CCDS55049.1
CCDS55050.1
PIR T08794
RefSeq NP_001157753.1
NP_001157755.1
NP_679211.2
XP_006715382.1
UniGene Hs.561514
Hs.740602
ProteinModelPortal O43734
SMR O43734
BioGrid 115979
IntAct O43734
MINT MINT-143208
STRING 9606.ENSP00000345984
PhosphoSite O43734
MaxQB O43734
PaxDb O43734
PRIDE O43734
DNASU 10758
Ensembl ENST00000340026
ENST00000359831
ENST00000368735
ENST00000368761
ENST00000392556
GeneID 10758
KEGG hsa:10758
UCSC uc003pvf.4
uc011ebb.3
CTD 10758
GeneCards GC06M111877
HGNC HGNC:1343
HPA HPA036352
MIM 607043
614070
615527
neXtProt NX_O43734
Orphanet 1334
PharmGKB PA25938
eggNOG NOG43147
GeneTree ENSGT00390000007714
HOVERGEN HBG002060
InParanoid O43734
OMA NYPSPWD
OrthoDB EOG7DVD9N
PhylomeDB O43734
TreeFam TF329063
SignaLink O43734
GeneWiki TRAF3IP2
GenomeRNAi 10758
NextBio 40857
PRO PR:O43734
Proteomes UP000005640
Bgee O43734
CleanEx HS_TRAF3IP2
Genevestigator O43734
GO GO:0001783
GO:0006959
GO:0048305
GO:0035556
GO:0043123
InterPro IPR013568
Pfam PF08357
PROSITE PS51534

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0002230

positive regulation of defense response to virus by host

PMID:23066157[1]

ECO:0000314

P

Figure 3 shows that Act1/CIKS expression is induced in response to dsRNA and Figure 4 shows that Act1 and IRF3 coexpression triggers antiviral signaling

complete
CACAO 5290

involved_in

GO:0002230

positive regulation of defense response to virus by host

PMID:23066157[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12761501[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:10962033[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005575

cellular_component

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002152027
UniProtKB:O43734

P

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2143599
PANTHER:PTN002152027

P

Seeded From UniProt

complete

involved_in

GO:0048305

immunoglobulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8N7N6
ensembl:ENSMUSP00000019987

P

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8N7N6
ensembl:ENSMUSP00000019987

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8N7N6
ensembl:ENSMUSP00000019987

F

Seeded From UniProt

complete

involved_in

GO:0001783

B cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8N7N6
ensembl:ENSMUSP00000019987

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Ryzhakov, G et al. (2012) IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling. J. Immunol. 189 4852-8 PubMed GONUTS page
  2. Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
  3. Leonardi, A et al. (2000) CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Proc. Natl. Acad. Sci. U.S.A. 97 10494-9 PubMed GONUTS page
  4. 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page