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HUMAN:CIKS
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TRAF3IP2 (synonyms: C6orf2, C6orf4, C6orf5, C6orf6) | |
| Protein Name(s) | Adapter protein CIKS
Connection to IKK and SAPK/JNK Nuclear factor NF-kappa-B activator 1 ACT1 TRAF3-interacting protein 2 | |
| External Links | ||
| UniProt | O43734 | |
| EMBL | AF136405 AF136406 AF136407 AF274303 AF272151 AK025351 AK026602 AK314415 AL050289 AL008730 AL008730 AL008730 AL008730 Z97989 Z97989 AL008730 Z97989 AL008730 CH471051 CH471051 BC002823 BI856094 | |
| CCDS | CCDS5093.1 CCDS55049.1 CCDS55050.1 | |
| PIR | T08794 | |
| RefSeq | NP_001157753.1 NP_001157755.1 NP_679211.2 XP_006715382.1 | |
| UniGene | Hs.561514 Hs.740602 | |
| ProteinModelPortal | O43734 | |
| SMR | O43734 | |
| BioGrid | 115979 | |
| IntAct | O43734 | |
| MINT | MINT-143208 | |
| STRING | 9606.ENSP00000345984 | |
| PhosphoSite | O43734 | |
| MaxQB | O43734 | |
| PaxDb | O43734 | |
| PRIDE | O43734 | |
| DNASU | 10758 | |
| Ensembl | ENST00000340026 ENST00000359831 ENST00000368735 ENST00000368761 ENST00000392556 | |
| GeneID | 10758 | |
| KEGG | hsa:10758 | |
| UCSC | uc003pvf.4 uc011ebb.3 | |
| CTD | 10758 | |
| GeneCards | GC06M111877 | |
| HGNC | HGNC:1343 | |
| HPA | HPA036352 | |
| MIM | 607043 614070 615527 | |
| neXtProt | NX_O43734 | |
| Orphanet | 1334 | |
| PharmGKB | PA25938 | |
| eggNOG | NOG43147 | |
| GeneTree | ENSGT00390000007714 | |
| HOVERGEN | HBG002060 | |
| InParanoid | O43734 | |
| OMA | NYPSPWD | |
| OrthoDB | EOG7DVD9N | |
| PhylomeDB | O43734 | |
| TreeFam | TF329063 | |
| SignaLink | O43734 | |
| GeneWiki | TRAF3IP2 | |
| GenomeRNAi | 10758 | |
| NextBio | 40857 | |
| PRO | PR:O43734 | |
| Proteomes | UP000005640 | |
| Bgee | O43734 | |
| CleanEx | HS_TRAF3IP2 | |
| Genevestigator | O43734 | |
| GO | GO:0001783 GO:0006959 GO:0048305 GO:0035556 GO:0043123 | |
| InterPro | IPR013568 | |
| Pfam | PF08357 | |
| PROSITE | PS51534 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000314 |
P |
Figure 3 shows that Act1/CIKS expression is induced in response to dsRNA and Figure 4 shows that Act1 and IRF3 coexpression triggers antiviral signaling |
complete | |||||
|
involved_in |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005575 |
cellular_component |
ECO:0000307 |
no biological data found used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002152027 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006959 |
humoral immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2143599 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048305 |
immunoglobulin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N7N6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006959 |
humoral immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N7N6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N7N6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001783 |
B cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N7N6 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ryzhakov, G et al. (2012) IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling. J. Immunol. 189 4852-8 PubMed GONUTS page
- ↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
- ↑ Leonardi, A et al. (2000) CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Proc. Natl. Acad. Sci. U.S.A. 97 10494-9 PubMed GONUTS page
- ↑ 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
