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HUMAN:CHRD

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CHRD
Protein Name(s) Chordin
External Links
UniProt Q9H2X0
EMBL AF209928
AF209929
AF209930
AF283325
AY358926
BC112345
AF076612
AF136632
AF136633
AF136634
AF136635
CCDS CCDS3266.1
RefSeq NP_003732.2
UniGene Hs.166186
ProteinModelPortal Q9H2X0
SMR Q9H2X0
BioGrid 114198
DIP DIP-48857N
IntAct Q9H2X0
MINT MINT-2817631
PhosphoSite Q9H2X0
DMDM 118572631
PaxDb Q9H2X0
PRIDE Q9H2X0
Ensembl ENST00000204604
ENST00000348986
ENST00000356534
ENST00000420973
ENST00000448472
GeneID 8646
KEGG hsa:8646
UCSC uc003fov.3
uc010hyc.3
CTD 8646
GeneCards GC03P184097
H-InvDB HIX0003911
HGNC HGNC:1949
HPA CAB020705
HPA035827
MIM 603475
neXtProt NX_Q9H2X0
PharmGKB PA26482
eggNOG NOG85639
GeneTree ENSGT00730000110792
HOVERGEN HBG005330
InParanoid Q9H2X0
KO K04657
OMA RDPGEGC
OrthoDB EOG7QNVK7
PhylomeDB Q9H2X0
TreeFam TF106451
GenomeRNAi 8646
NextBio 32415
PMAP-CutDB Q9H2X0
PRO PR:Q9H2X0
Proteomes UP000005640
Bgee Q9H2X0
ExpressionAtlas Q9H2X0
Genevestigator Q9H2X0
GO GO:0005615
GO:0019955
GO:0008201
GO:0021919
GO:0033504
GO:0030900
GO:0001702
GO:0001707
GO:0030514
GO:0030336
GO:0045668
GO:0001649
GO:0045785
GO:0002053
GO:0001501
InterPro IPR016353
IPR010895
IPR001007
Pfam PF07452
PF00093
PIRSF PIRSF002496
SMART SM00754
SM00214
PROSITE PS50933
PS01208
PS50184

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045785

positive regulation of cell adhesion

PMID:16449796[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045668

negative regulation of osteoblast differentiation

PMID:18533030[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030514

negative regulation of BMP signaling pathway

PMID:11472837[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

PMID:16449796[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021919

BMP signaling pathway involved in spinal cord dorsal/ventral patterning

PMID:11472837[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019955

cytokine binding

PMID:16449796[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16449796[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002053

positive regulation of mesenchymal cell proliferation

PMID:18533030[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045668

negative regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

enables

GO:0045545

syndecan binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

F

Seeded From UniProt

complete

involved_in

GO:0030900

forebrain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

involved_in

GO:0030514

negative regulation of BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

involved_in

GO:0009953

dorsal/ventral pattern formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

F

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

C

Seeded From UniProt

complete

involved_in

GO:0001707

mesoderm formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

involved_in

GO:0001702

gastrulation with mouth forming second

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0E2
ensembl:ENSMUSP00000007171

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016353

P

Seeded From UniProt

complete

involved_in

GO:0033504

floor plate development

PMID:11790302[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

PMID:9782094[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Moll, F et al. (2006) Chordin is underexpressed in ovarian tumors and reduces tumor cell motility. FASEB J. 20 240-50 PubMed GONUTS page
  2. ↑ 2.0 2.1 Kwong, FN et al. (2008) Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells. Arthritis Res. Ther. 10 R65 PubMed GONUTS page
  3. ↑ 3.0 3.1 Millet, C et al. (2001) The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities. Mech. Dev. 106 85-96 PubMed GONUTS page
  4. ↑ Patten, I & Placzek, M (2002) Opponent activities of Shh and BMP signaling during floor plate induction in vivo. Curr. Biol. 12 47-52 PubMed GONUTS page
  5. ↑ Pappano, WN et al. (1998) Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes. Genomics 52 236-9 PubMed GONUTS page
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