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HUMAN:CD63
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CD63 (synonyms: MLA1, TSPAN30) | |
| Protein Name(s) | CD63 antigen
Granulophysin Lysosomal-associated membrane protein 3 LAMP-3 Melanoma-associated antigen ME491 OMA81H Ocular melanoma-associated antigen Tetraspanin-30 Tspan-30 | |
| External Links | ||
| UniProt | P08962 | |
| EMBL | X07982 M59907 M58485 S93788 X62654 AF508304 AK311893 CR542096 BT007073 BT020137 BT020138 AC009779 CH471054 BC002349 BC013017 | |
| CCDS | CCDS58242.1 CCDS58243.1 CCDS8890.1 | |
| PIR | I38016 | |
| RefSeq | NP_001244318.1 NP_001244319.1 NP_001244320.1 NP_001244321.1 NP_001244329.1 NP_001244330.1 NP_001254627.1 NP_001771.1 | |
| UniGene | Hs.445570 | |
| ProteinModelPortal | P08962 | |
| BioGrid | 107405 | |
| IntAct | P08962 | |
| MINT | MINT-2981823 | |
| STRING | 9606.ENSP00000257857 | |
| PhosphoSite | P08962 | |
| DMDM | 116026 | |
| MaxQB | P08962 | |
| PaxDb | P08962 | |
| PRIDE | P08962 | |
| DNASU | 967 | |
| Ensembl | ENST00000257857 ENST00000420846 ENST00000546939 ENST00000549117 ENST00000550776 ENST00000552692 ENST00000552754 | |
| GeneID | 967 | |
| KEGG | hsa:967 | |
| UCSC | uc001shn.4 uc009znz.4 | |
| CTD | 967 | |
| GeneCards | GC12M056119 | |
| HGNC | HGNC:1692 | |
| HPA | CAB026356 HPA010088 | |
| MIM | 155740 | |
| neXtProt | NX_P08962 | |
| PharmGKB | PA26231 | |
| eggNOG | NOG268658 | |
| GeneTree | ENSGT00760000118875 | |
| HOGENOM | HOG000230651 | |
| HOVERGEN | HBG107306 | |
| InParanoid | P08962 | |
| KO | K06497 | |
| OMA | MITFAVF | |
| PhylomeDB | P08962 | |
| TreeFam | TF316345 | |
| ChiTaRS | CD63 | |
| GeneWiki | CD63 | |
| GenomeRNAi | 967 | |
| NextBio | 4044 | |
| PRO | PR:P08962 | |
| Proteomes | UP000005640 | |
| Bgee | P08962 | |
| CleanEx | HS_CD63 | |
| ExpressionAtlas | P08962 | |
| Genevestigator | P08962 | |
| GO | GO:0009986 GO:0031904 GO:0010008 GO:0070062 GO:0005887 GO:0031226 GO:0031902 GO:0005765 GO:0042470 GO:0097487 GO:0005886 GO:0031088 GO:0007596 GO:0016477 GO:0007160 GO:0034613 GO:0035646 GO:0048757 GO:0030168 GO:0002576 GO:2001046 GO:0002092 GO:0015031 GO:2000680 GO:1900746 | |
| InterPro | IPR000301 IPR018499 IPR018503 IPR008952 | |
| Pfam | PF00335 | |
| PIRSF | PIRSF002419 | |
| PRINTS | PR00259 | |
| SUPFAM | SSF48652 | |
| PROSITE | PS00421 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030139 |
endocytic vesicle |
ECO:0000315 |
C |
Fig. 6B and Fig. 7B |
complete | |||||
|
part_of |
GO:0005765 |
lysosomal membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097487 |
multivesicular body, internal vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032585 |
multivesicular body membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032585 |
multivesicular body membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000236) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007311) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010008 |
endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031904 |
endosome lumen |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000178) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2001046 |
positive regulation of integrin-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001046 |
positive regulation of integrin-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900746 |
regulation of vascular endothelial growth factor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097487 |
multivesicular body, internal vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048757 |
pigment granule maturation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035646 |
endosome to melanosome transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031902 |
late endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031226 |
intrinsic component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031226 |
intrinsic component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007160 |
cell-matrix adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005765 |
lysosomal membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005765 |
lysosomal membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002092 |
positive regulation of receptor internalization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900746 |
regulation of vascular endothelial growth factor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99529 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1889818 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901379 |
regulation of potassium ion transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034613 |
cellular protein localization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010008 |
endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900746 |
regulation of vascular endothelial growth factor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41731 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050931 |
pigment cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41731 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043473 |
pigmentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41731 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005770 |
late endosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41731 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41731 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000301 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
PMID:9602068[20] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005765 |
lysosomal membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035577 |
azurophil granule membrane |
Reactome:R-HSA-6798739 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031088 |
platelet dense granule membrane |
Reactome:R-HSA-481010 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005765 |
lysosomal membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031902 |
late endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005771 |
multivesicular body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Caillet, M et al. (2011) Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog. 7 e1002347 PubMed GONUTS page
- ↑ Mamo, A et al. (2012) The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting. Mol. Cell. Biol. 32 1855-66 PubMed GONUTS page
- ↑ 3.0 3.1 Blom, T et al. (2015) LAPTM4B facilitates late endosomal ceramide export to control cell death pathways. Nat. Chem. Biol. 11 799-806 PubMed GONUTS page
- ↑ Wubbolts, R et al. (2003) Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278 10963-72 PubMed GONUTS page
- ↑ Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
- ↑ 6.0 6.1 Baietti, MF et al. (2012) Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat. Cell Biol. 14 677-85 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Caby, MP et al. (2005) Exosomal-like vesicles are present in human blood plasma. Int. Immunol. 17 879-87 PubMed GONUTS page
- ↑ Zheng, Y et al. (2013) Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis. Exp. Cell Res. 319 1706-13 PubMed GONUTS page
- ↑ Mittelbrunn, M et al. (2011) Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun 2 282 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 Tugues, S et al. (2013) Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo. J. Biol. Chem. 288 19060-71 PubMed GONUTS page
- ↑ 13.0 13.1 Jung, KK et al. (2006) Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J. 25 3934-42 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 van Niel, G et al. (2011) The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev. Cell 21 708-21 PubMed GONUTS page
- ↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
- ↑ 16.0 16.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Codina, J et al. (2005) CD63 interacts with the carboxy terminus of the colonic H+-K+-ATPase to decrease [corrected] plasma membrane localization and 86Rb+ uptake. Am. J. Physiol., Cell Physiol. 288 C1279-86 PubMed GONUTS page
- ↑ Coumailleau, F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol. Biol. Cell 15 4444-56 PubMed GONUTS page
- ↑ 19.0 19.1 Metzelaar, MJ et al. (1991) CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J. Biol. Chem. 266 3239-45 PubMed GONUTS page
- ↑ Fitter, S et al. (1998) Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms. Biochim. Biophys. Acta 1398 75-85 PubMed GONUTS page
- ↑ Gwynn, B et al. (1996) Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. Genomics 35 389-91 PubMed GONUTS page
c
e
- GO:0030139 ! endocytic vesicle
- GO:0005768 ! endosome
- GO:0031904 ! endosome lumen
- GO:0010008 ! endosome membrane
- GO:0035646 ! endosome to melanosome transport
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0070062 ! extracellular exosome
- GO:0005615 ! extracellular space
- GO:0005576 ! extracellular region
l
m
p
- GO:0043473 ! pigmentation
- GO:0050931 ! pigment cell differentiation
- GO:0048757 ! pigment granule maturation
- GO:0005886 ! plasma membrane
- GO:0002576 ! platelet degranulation
- GO:0031088 ! platelet dense granule membrane
- GO:0002092 ! positive regulation of receptor internalization
- GO:2001046 ! positive regulation of integrin-mediated signaling pathway
- Primates
- GO:0015031 ! protein transport
r
