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HUMAN:CCR9

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CCR9 (synonyms: GPR28)
Protein Name(s) C-C chemokine receptor type 9

C-C CKR-9 CC-CKR-9 CCR-9 G-protein coupled receptor 28 GPR-9-6

External Links
UniProt P51686
EMBL AJ132337
AF145439
AF145440
U45982
AY242127
BC069678
BC095516
CCDS CCDS2732.1
CCDS2733.1
RefSeq NP_001243298.1
NP_006632.2
NP_112477.1
UniGene Hs.225946
ProteinModelPortal P51686
SMR P51686
DIP DIP-5884N
MINT MINT-106203
STRING 9606.ENSP00000350256
BindingDB P51686
ChEMBL CHEMBL5815
GuidetoPHARMACOLOGY 66
PhosphoSite P51686
DMDM 114152781
PaxDb P51686
PRIDE P51686
DNASU 10803
Ensembl ENST00000355983
ENST00000357632
ENST00000395963
GeneID 10803
KEGG hsa:10803
UCSC uc003coz.2
CTD 10803
GeneCards GC03P045903
HGNC HGNC:1610
HPA CAB006839
MIM 604738
neXtProt NX_P51686
PharmGKB PA26174
eggNOG NOG268585
GeneTree ENSGT00760000118785
HOGENOM HOG000234122
HOVERGEN HBG106917
InParanoid P51686
KO K04184
OMA ISTNIDI
OrthoDB EOG77WWD0
PhylomeDB P51686
TreeFam TF330966
Reactome REACT_15344
REACT_19231
GeneWiki CCR9
GenomeRNAi 10803
NextBio 41035
PRO PR:P51686
Proteomes UP000005640
Bgee P51686
CleanEx HS_CCR9
ExpressionAtlas P51686
Genevestigator P51686
GO GO:0009986
GO:0005887
GO:0005886
GO:0016493
GO:0004950
GO:0006968
GO:0070098
GO:0006935
GO:0007186
GO:0006955
GO:0007204
InterPro IPR004069
IPR000355
IPR000276
IPR017452
PANTHER PTHR24227
Pfam PF00001
PRINTS PR00657
PR01531
PR00237
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0009986

cell surface

PMID:18308860[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

involved_in

GO:0060326

cell chemotaxis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200797
UniProtKB:P51684

P

Seeded From UniProt

complete

enables

GO:0019957

C-C chemokine binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104616
MGI:MGI:107182
MGI:MGI:1333797
MGI:MGI:1891697
PANTHER:PTN001200797
RGD:708446
UniProtKB:P32246
UniProtKB:P51677
UniProtKB:P51681
UniProtKB:P51684
UniProtKB:P61073

F

Seeded From UniProt

complete

enables

GO:0019956

chemokine binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200797
UniProtKB:P49682
ZFIN:ZDB-GENE-031116-61

F

Seeded From UniProt

complete

involved_in

GO:0019722

calcium-mediated signaling

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200797
RGD:621528
UniProtKB:P51681
UniProtKB:P51684
UniProtKB:P61073

P

Seeded From UniProt

complete

enables

GO:0016493

C-C chemokine receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:104616
MGI:MGI:104618
MGI:MGI:106185
MGI:MGI:107182
MGI:MGI:107824
MGI:MGI:1096320
MGI:MGI:1201402
MGI:MGI:1333797
MGI:MGI:1341902
MGI:MGI:1891697
PANTHER:PTN001200797
UniProtKB:P32246
UniProtKB:P51681
UniProtKB:P51684

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:103567
MGI:MGI:106185
MGI:MGI:107182
MGI:MGI:107824
MGI:MGI:109563
MGI:MGI:1277207
MGI:MGI:1333797
PANTHER:PTN001200797
RGD:621528
RGD:708446
UniProtKB:P32246
UniProtKB:P51681

C

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096320
PANTHER:PTN001200797
RGD:1308562
RGD:2906
RGD:620596
RGD:621528
UniProtKB:P32246

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:106185
PANTHER:PTN001628461
UniProtKB:P32246

P

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:104616
MGI:MGI:107824
MGI:MGI:1096320
MGI:MGI:1201402
MGI:MGI:1333797
MGI:MGI:1341902
MGI:MGI:1346338
PANTHER:PTN001200797
UniProtKB:F1R6D3
UniProtKB:P25025
UniProtKB:P51684
ZFIN:ZDB-GENE-031116-61

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004950

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016493

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016493

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004950

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016493

P

Seeded From UniProt

complete

enables

GO:0016493

C-C chemokine receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUT7
ensembl:ENSMUSP00000127024

F

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUT7
ensembl:ENSMUSP00000127024

P

Seeded From UniProt

complete

involved_in

GO:0002305

CD8-positive, gamma-delta intraepithelial T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUT7
ensembl:ENSMUSP00000127024

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004950

chemokine receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000355

F

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000355
InterPro:IPR004069

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004069

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000355
InterPro:IPR004069

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000355
InterPro:IPR004069
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0016493

C-C chemokine receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004069

F

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:10229797[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:10544196[4]
Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006968

cellular defense response

PMID:10544196[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:10229797[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

PMID:10640743[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:10229797[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10229797[3]
Reactome:R-HSA-749456
Reactome:R-HSA-749454
Reactome:R-HSA-380073
Reactome:R-HSA-373074

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0004950

chemokine receptor activity

PMID:10229797[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Miles, A et al. (2008) CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am. J. Physiol. Gastrointest. Liver Physiol. 294 G1257-67 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Zaballos, A et al. (1999) Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol. 162 5671-5 PubMed GONUTS page
  4. ↑ 4.0 4.1 Zabel, BA et al. (1999) Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J. Exp. Med. 190 1241-56 PubMed GONUTS page
  5. ↑ Yu, CR et al. (2000) CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand. J. Immunol. 164 1293-305 PubMed GONUTS page
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