HUMAN:BMR1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BMPR1A (synonyms: ACVRLK3, ALK3)
Protein Name(s)	Bone morphogenetic protein receptor type-1A BMP type-1A receptor BMPR-1A Activin receptor-like kinase 3 ALK-3 Serine/threonine-protein kinase receptor R5 SKR5
External Links
UniProt	P36894
EMBL	Z22535 AK291764 BC028383
CCDS	CCDS7378.1
PIR	I37163
RefSeq	NP_004320.2
UniGene	Hs.524477
PDB	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
PDBsum	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
ProteinModelPortal	P36894
SMR	P36894
BioGrid	107125
DIP	DIP-5793N
IntAct	P36894
MINT	MINT-124304
STRING	9606.ENSP00000224764
BindingDB	P36894
ChEMBL	CHEMBL5275
GuidetoPHARMACOLOGY	1786
PhosphoSite	P36894
DMDM	61252444
MaxQB	P36894
PaxDb	P36894
PRIDE	P36894
DNASU	657
Ensembl	ENST00000372037
GeneID	657
KEGG	hsa:657
UCSC	uc001kdy.3
CTD	657
GeneCards	GC10P088506
GeneReviews	BMPR1A
HGNC	HGNC:1076
HPA	CAB019398
MIM	174900 601299 610069 612242
neXtProt	NX_P36894
Orphanet	329971 157794 144 79076
PharmGKB	PA25386
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000230587
HOVERGEN	HBG054502
InParanoid	P36894
KO	K04673
OMA	CYNRDLE
OrthoDB	EOG7Q8CN3
PhylomeDB	P36894
TreeFam	TF314724
BRENDA	2.7.10.2
Reactome	REACT_12034
SignaLink	P36894
ChiTaRS	BMPR1A
EvolutionaryTrace	P36894
GeneWiki	BMPR1A
GenomeRNAi	657
NextBio	2672
PRO	PR:P36894
Proteomes	UP000005640
Bgee	P36894
CleanEx	HS_BMPR1A
Genevestigator	P36894
GO	GO:0030425 GO:0016021 GO:0043025 GO:0005886 GO:0005524 GO:0046872 GO:0042803 GO:0004674 GO:0004702 GO:0000981 GO:0046332 GO:0005024 GO:0004675 GO:0030509 GO:0051216 GO:0048589 GO:0009950 GO:0007398 GO:0042733 GO:0048568 GO:0003272 GO:0060914 GO:0035137 GO:0006955 GO:0001701 GO:0048368 GO:0030324 GO:0048382 GO:0001707 GO:0001880 GO:0050768 GO:0014032 GO:0021998 GO:0042475 GO:0060021 GO:0048352 GO:0021983 GO:0030501 GO:0050679 GO:0002053 GO:0045669 GO:0010862 GO:0060391 GO:0045893 GO:0006468 GO:0048378 GO:0001756 GO:0019827 GO:0007179
InterPro	IPR000472 IPR011009 IPR000719 IPR017441 IPR008271 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18667463^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P	has_regulation_target:(UniProtKB:P08253) occurs_in:(UBERON:0002111) occurs_in:(UBERON:0002012)\|has_regulation_target(UniProtKB:P14780) occurs_in:(UBERON:0002012) occurs_in:(UBERON:0002111)	Seeded From UniProt	complete
involved_in	GO:1905285	fibrous ring of heart morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0060043	regulation of cardiac muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003223	ventricular compact myocardium morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003222	ventricular trabecula myocardium morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003186	tricuspid valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P	occurs_in:(UBERON:0002133) has_regulation_target:(UniProtKB:Q62009)	Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0003203	P		Seeded From UniProt	complete
involved_in	GO:0003161	cardiac conduction system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0014912	negative regulation of smooth muscle cell migration	PMID:18667463^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002012)	Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	PMID:18667463^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002012)	Seeded From UniProt	complete
involved_in	GO:1904414	positive regulation of cardiac ventricle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0035912	dorsal aorta morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0010665	regulation of cardiac muscle cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
NOT\|involved_in	GO:1905292	regulation of neural crest cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990712	HFE-transferrin receptor complex	PMID:24904118^[3]	ECO:0000305	curator inference used in manual assertion	GO:0005515	C		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:P81172)\|part_of(GO:0071773) occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:24904118^[3]	ECO:0000305	curator inference used in manual assertion	GO:0010862	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:24904118^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:24904118^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15797)\|has_regulation_target:(UniProtKB:Q99717)\|has_regulation_target:(UniProtKB:O15198)	Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	PMID:9389648^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:18436533^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18436533^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:9389648^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18436533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:18436533^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:9389648^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:16886151^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	PMID:15657086^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15657086^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36895	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:107191 PANTHER:PTN001147404	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
involved_in	GO:0048368	lateral mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0048352	paraxial mesoderm structural organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0048339	paraxial mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0035912	dorsal aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0035137	hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0021998	neural plate mediolateral regionalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	C		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003223	ventricular compact myocardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003222	ventricular trabecula myocardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003186	tricuspid valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003161	cardiac conduction system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0001880	Mullerian duct regression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	F		Seeded From UniProt	complete
involved_in	GO:2000772	regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:1905285	fibrous ring of heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:1904414	positive regulation of cardiac ventricle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	F		Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0060914	heart formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0060896	neural plate pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0060043	regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0048598	embryonic morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0048382	mesendoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
involved_in	GO:0048378	regulation of lateral mesodermal cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36895 ensembl:ENSMUSP00000035900	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q78EA7 ensembl:ENSRNOP00000074885	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q78EA7 ensembl:ENSRNOP00000074885	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR003605 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:8397373^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:8397373^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-202604 Reactome:R-HSA-201821 Reactome:R-HSA-201648 Reactome:R-HSA-201476 Reactome:R-HSA-201475 Reactome:R-HSA-201457 Reactome:R-HSA-201453 Reactome:R-HSA-201443	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Reactome:R-HSA-201476	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 El-Bizri, N et al. (2008) SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development 135 2981-91 PubMed GONUTS page
↑ ^2.0 ^2.1 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Wu, XG et al. (2014) HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood 124 1335-43 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page
↑ Adewoye, AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin. Infect. Dis. 43 593-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Nohe, A et al. (2005) Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J. Cell. Sci. 118 643-50 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Inman, GJ et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62 65-74 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ten Dijke, P et al. (1993) Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene 8 2879-87 PubMed GONUTS page

[PMID:18667463-1] 1.0 ^1.1 ^1.2 El-Bizri, N et al. (2008) SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development 135 2981-91 PubMed GONUTS page

[PMID:18326817-2] 2.0 ^2.1 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page

[PMID:24904118-3] 3.0 ^3.1 ^3.2 ^3.3 Wu, XG et al. (2014) HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood 124 1335-43 PubMed GONUTS page

[PMID:9389648-4] 4.0 ^4.1 ^4.2 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page

[PMID:18436533-5] 5.0 ^5.1 ^5.2 ^5.3 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page

[PMID:16886151-6] Adewoye, AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin. Infect. Dis. 43 593-8 PubMed GONUTS page

[PMID:15657086-7] 7.0 ^7.1 Nohe, A et al. (2005) Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J. Cell. Sci. 118 643-50 PubMed GONUTS page

[PMID:12065756-8] 8.0 ^8.1 ^8.2 ^8.3 Inman, GJ et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62 65-74 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8397373-10] 10.0 ^10.1 ten Dijke, P et al. (1993) Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene 8 2879-87 PubMed GONUTS page

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