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HUMAN:BLK

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BLK
Protein Name(s) Tyrosine-protein kinase Blk

B lymphocyte kinase p55-Blk

External Links
UniProt P51451
EMBL Z33998
S76617
AK313751
CH471157
BC007371
BC032413
CCDS CCDS5982.1
PIR I37206
RefSeq NP_001706.2
XP_006716313.1
XP_006716314.1
UniGene Hs.146591
ProteinModelPortal P51451
SMR P51451
BioGrid 107109
IntAct P51451
MINT MINT-1494192
STRING 9606.ENSP00000259089
BindingDB P51451
ChEMBL CHEMBL2363074
GuidetoPHARMACOLOGY 1940
PhosphoSite P51451
DMDM 158936749
MaxQB P51451
PaxDb P51451
PRIDE P51451
DNASU 640
Ensembl ENST00000259089
GeneID 640
KEGG hsa:640
UCSC uc003wty.3
CTD 640
GeneCards GC08P011388
H-InvDB HIX0007315
HIX0168887
HGNC HGNC:1057
HPA CAB005093
MIM 191305
613375
neXtProt NX_P51451
Orphanet 552
536
PharmGKB PA25368
eggNOG COG0515
GeneTree ENSGT00760000118938
HOGENOM HOG000233858
HOVERGEN HBG008761
InParanoid P51451
KO K08890
OMA QMNSIHR
OrthoDB EOG7GTT2V
PhylomeDB P51451
TreeFam TF351634
BRENDA 2.7.10.2
Reactome REACT_118700
SignaLink P51451
ChiTaRS BLK
GeneWiki Tyrosine-protein_kinase_BLK
GenomeRNAi 640
NextBio 2596
PRO PR:P51451
Proteomes UP000005640
Bgee P51451
CleanEx HS_BLK
ExpressionAtlas P51451
Genevestigator P51451
GO GO:0005886
GO:0005524
GO:0004715
GO:0004713
GO:0050853
GO:0035556
GO:0018108
GO:0032024
Gene3D 3.30.505.10
InterPro IPR011009
IPR000719
IPR017441
IPR001245
IPR000980
IPR001452
IPR020635
Pfam PF07714
PF00017
PF00018
PRINTS PR00401
PR00452
PR00109
SMART SM00252
SM00326
SM00219
SUPFAM SSF50044
SSF55550
SSF56112
PROSITE PS00107
PS50011
PS50001
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004713

protein tyrosine kinase activity

PMID:30356214[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:30356214[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

PMID:876631[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032024

positive regulation of insulin secretion

PMID:19667185[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:876631[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0038083

peptidyl-tyrosine autophosphorylation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
UniProtKB:Q9H3Y6
WB:WBGene00005077

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
UniProtKB:P08631

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
RGD:621423

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
UniProtKB:P07948

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262733
PANTHER:PTN002521528
RGD:2641
RGD:620795
RGD:621017
UniProtKB:P12931

F

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95527
PANTHER:PTN002521528
UniProtKB:P09769
UniProtKB:P51451
UniProtKB:Q13882
WB:WBGene00005077

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR020635

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.2

F

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:2404338[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:7845672[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050855

regulation of B cell receptor signaling pathway

Reactome:R-HSA-8939245

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8938987

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Liu, H et al. (2018) Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature 563 131-136 PubMed GONUTS page
  2. ↑ 2.0 2.1 Azolov, VV (1977) [Restoration of the function of bilateral hand grip at the expense of the fingers of the same hand]. Ortop Travmatol Protez 60-5 PubMed GONUTS page
  3. ↑ Borowiec, M et al. (2009) Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc. Natl. Acad. Sci. U.S.A. 106 14460-5 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Dymecki, SM et al. (1990) Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science 247 332-6 PubMed GONUTS page
  6. ↑ Drebin, JA et al. (1995) Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). Oncogene 10 477-86 PubMed GONUTS page
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