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HUMAN:BGH3
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | TGFBI (synonyms: BIGH3) | |
Protein Name(s) | Transforming growth factor-beta-induced protein ig-h3
Beta ig-h3 Kerato-epithelin RGD-containing collagen-associated protein RGD-CAP | |
External Links | ||
UniProt | Q15582 | |
EMBL | M77349 AF035626 AF035627 AF035628 AF035629 AY149344 BT009820 AC004503 AC005219 CH471062 CH471062 BC000097 BC004972 | |
CCDS | CCDS47266.1 | |
PIR | I52996 | |
RefSeq | NP_000349.1 | |
UniGene | Hs.369397 | |
PDB | 1X3B 2LTB 2LTC 2VXP | |
PDBsum | 1X3B 2LTB 2LTC 2VXP | |
ProteinModelPortal | Q15582 | |
SMR | Q15582 | |
BioGrid | 112903 | |
MINT | MINT-122359 | |
STRING | 9606.ENSP00000416330 | |
PhosphoSite | Q15582 | |
DMDM | 2498193 | |
MaxQB | Q15582 | |
PaxDb | Q15582 | |
PeptideAtlas | Q15582 | |
PRIDE | Q15582 | |
DNASU | 7045 | |
Ensembl | ENST00000442011 | |
GeneID | 7045 | |
KEGG | hsa:7045 | |
UCSC | uc003lbf.4 | |
CTD | 7045 | |
GeneCards | GC05P135364 | |
HGNC | HGNC:11771 | |
HPA | HPA008612 HPA017019 | |
MIM | 121820 121900 122200 601692 602082 607541 608470 608471 | |
neXtProt | NX_Q15582 | |
Orphanet | 98962 98963 98964 98956 98961 98960 | |
PharmGKB | PA36484 | |
eggNOG | COG2335 | |
GeneTree | ENSGT00530000063860 | |
HOVERGEN | HBG000715 | |
InParanoid | Q15582 | |
OMA | KNHILKS | |
OrthoDB | EOG7N8ZV1 | |
PhylomeDB | Q15582 | |
TreeFam | TF316269 | |
Reactome | REACT_75925 | |
ChiTaRS | TGFBI | |
EvolutionaryTrace | Q15582 | |
GeneWiki | TGFBI | |
GenomeRNAi | 7045 | |
NextBio | 27529 | |
PRO | PR:Q15582 | |
Proteomes | UP000005640 | |
Bgee | Q15582 | |
CleanEx | HS_TGFBI | |
ExpressionAtlas | Q15582 | |
Genevestigator | Q15582 | |
GO | GO:0005604 GO:0005576 GO:0005615 GO:0070062 GO:0005886 GO:0005802 GO:0005518 GO:0050840 GO:0005178 GO:0001525 GO:0007155 GO:0008283 GO:0002062 GO:0030198 GO:0007162 GO:0050896 GO:0007601 | |
Gene3D | 2.30.180.10 | |
InterPro | IPR011489 IPR000782 IPR016666 | |
Pfam | PF02469 | |
PIRSF | PIRSF016553 | |
SMART | SM00554 | |
SUPFAM | SSF82153 | |
PROSITE | PS51041 PS50213 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(CL:0002540) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002540) |
Seeded From UniProt |
complete | ||
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(CL:0002543) |
Seeded From UniProt |
complete | ||
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0001496) |
Seeded From UniProt |
complete | ||
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
occurs_in:(UBERON:0002084) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0003688)|part_of:(UBERON:0001911) |
Seeded From UniProt |
complete | ||
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0003688)|occurs_in:(UBERON:0001911) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002543) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
colocalizes_with |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001496) |
Seeded From UniProt |
complete | ||
colocalizes_with |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005518 |
collagen binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002367) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050839 |
cell adhesion molecule binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262742 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1926321 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1926321 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1926321 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99959 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005604 |
basement membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A8G5 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002062 |
chondrocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A8G5 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0050840 |
extracellular matrix binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P82198 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P82198 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P82198 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P82198 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P82198 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005178 |
integrin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005518 |
collagen binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050840 |
extracellular matrix binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007601 |
visual perception |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007162 |
negative regulation of cell adhesion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005178 |
integrin binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-977136 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-977136 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050896 |
response to stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007601 |
visual perception |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
- ↑ 2.0 2.1 Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
- ↑ 3.0 3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
- ↑ 4.0 4.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
- ↑ 5.0 5.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Kim, BY et al. (2009) Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome. J. Biol. Chem. 284 19580-91 PubMed GONUTS page
- ↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
- ↑ Aitkenhead, M et al. (2002) Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc. Res. 63 159-71 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Skonier, J et al. (1992) cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol. 11 511-22 PubMed GONUTS page
- ↑ Korvatska, E et al. (1998) Mutation hot spots in 5q31-linked corneal dystrophies. Am. J. Hum. Genet. 62 320-4 PubMed GONUTS page
- ↑ Skonier, J et al. (1994) beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol. 13 571-84 PubMed GONUTS page
c
- Catarrhini
- GO:0044267 ! cellular protein metabolic process
- GO:0007155 ! cell adhesion
- GO:0050839 ! cell adhesion molecule binding
- GO:0008283 ! cell population proliferation
- GO:0002062 ! chondrocyte differentiation
- Chordata
- GO:0062023 ! collagen-containing extracellular matrix
- GO:0005518 ! collagen binding
- Craniata
e
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0030198 ! extracellular matrix organization
- GO:0050840 ! extracellular matrix binding
- GO:0031012 ! extracellular matrix
- GO:0005615 ! extracellular space
- GO:0070062 ! extracellular exosome
- GO:0005576 ! extracellular region
- GO:0005201 ! extracellular matrix structural constituent