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HUMAN:BGH3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TGFBI (synonyms: BIGH3)
Protein Name(s) Transforming growth factor-beta-induced protein ig-h3

Beta ig-h3 Kerato-epithelin RGD-containing collagen-associated protein RGD-CAP

External Links
UniProt Q15582
EMBL M77349
AF035626
AF035627
AF035628
AF035629
AY149344
BT009820
AC004503
AC005219
CH471062
CH471062
BC000097
BC004972
CCDS CCDS47266.1
PIR I52996
RefSeq NP_000349.1
UniGene Hs.369397
PDB 1X3B
2LTB
2LTC
2VXP
PDBsum 1X3B
2LTB
2LTC
2VXP
ProteinModelPortal Q15582
SMR Q15582
BioGrid 112903
MINT MINT-122359
STRING 9606.ENSP00000416330
PhosphoSite Q15582
DMDM 2498193
MaxQB Q15582
PaxDb Q15582
PeptideAtlas Q15582
PRIDE Q15582
DNASU 7045
Ensembl ENST00000442011
GeneID 7045
KEGG hsa:7045
UCSC uc003lbf.4
CTD 7045
GeneCards GC05P135364
HGNC HGNC:11771
HPA HPA008612
HPA017019
MIM 121820
121900
122200
601692
602082
607541
608470
608471
neXtProt NX_Q15582
Orphanet 98962
98963
98964
98956
98961
98960
PharmGKB PA36484
eggNOG COG2335
GeneTree ENSGT00530000063860
HOVERGEN HBG000715
InParanoid Q15582
OMA KNHILKS
OrthoDB EOG7N8ZV1
PhylomeDB Q15582
TreeFam TF316269
Reactome REACT_75925
ChiTaRS TGFBI
EvolutionaryTrace Q15582
GeneWiki TGFBI
GenomeRNAi 7045
NextBio 27529
PRO PR:Q15582
Proteomes UP000005640
Bgee Q15582
CleanEx HS_TGFBI
ExpressionAtlas Q15582
Genevestigator Q15582
GO GO:0005604
GO:0005576
GO:0005615
GO:0070062
GO:0005886
GO:0005802
GO:0005518
GO:0050840
GO:0005178
GO:0001525
GO:0007155
GO:0008283
GO:0002062
GO:0030198
GO:0007162
GO:0050896
GO:0007601
Gene3D 2.30.180.10
InterPro IPR011489
IPR000782
IPR016666
Pfam PF02469
PIRSF PIRSF016553
SMART SM00554
SUPFAM SSF82153
PROSITE PS51041
PS50213

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0005201

extracellular matrix structural constituent

PMID:28327460[1]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(CL:0002540)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28327460[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002540)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:23979707[2]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(CL:0002543)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:27559042[3]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

  • occurs_in:(UBERON:0006618)
  • occurs_in:(UBERON:0002302)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:20551380[4]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001496)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O11780

F

occurs_in:(UBERON:0002084)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)|part_of:(UBERON:0001911)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:28675934[5]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0003688)|occurs_in:(UBERON:0001911)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:25037231[6]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001155)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:25037231[6]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:27068509[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:23979707[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002543)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:22261194[9]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O11780

C

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

PMID:19478074[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:19478074[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

PMID:19478074[10]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A8TX70

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:21362503[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002367)

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

PMID:11866539[12]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050839

cell adhesion molecule binding

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262742
PANTHER:PTN000855676

F

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1926321
MGI:MGI:99959
PANTHER:PTN000855676

C

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1926321
MGI:MGI:99959
PANTHER:PTN000855676

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1926321
MGI:MGI:99959
PANTHER:PTN000855676
UniProtKB:Q15063

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99959
PANTHER:PTN000096377
RGD:1305285
UniProtKB:Q15582

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A8G5
ensembl:ENSRNOP00000016389

C

Seeded From UniProt

complete

involved_in

GO:0002062

chondrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A8G5
ensembl:ENSRNOP00000016389

P

Seeded From UniProt

complete

enables

GO:0050840

extracellular matrix binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P82198
ensembl:ENSMUSP00000037719

F

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P82198
ensembl:ENSMUSP00000037719

C

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P82198
ensembl:ENSMUSP00000037719

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P82198
ensembl:ENSMUSP00000037719

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P82198
ensembl:ENSMUSP00000037719

C

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032954

F

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032954

F

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032954

P

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032954

P

Seeded From UniProt

complete

enables

GO:0050840

extracellular matrix binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032954

F

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:1388724[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

PMID:9463327[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007162

negative regulation of cell adhesion

PMID:8024701[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:1388724[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

PMID:1388724[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-977136
Reactome:R-HSA-976734

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-977136

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0844

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
  2. 2.0 2.1 Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
  3. 3.0 3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
  4. 4.0 4.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  5. 5.0 5.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  7. Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  8. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  9. Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
  10. 10.0 10.1 10.2 Kim, BY et al. (2009) Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome. J. Biol. Chem. 284 19580-91 PubMed GONUTS page
  11. Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
  12. Aitkenhead, M et al. (2002) Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc. Res. 63 159-71 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  14. 14.0 14.1 14.2 Skonier, J et al. (1992) cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol. 11 511-22 PubMed GONUTS page
  15. Korvatska, E et al. (1998) Mutation hot spots in 5q31-linked corneal dystrophies. Am. J. Hum. Genet. 62 320-4 PubMed GONUTS page
  16. Skonier, J et al. (1994) beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol. 13 571-84 PubMed GONUTS page