HUMAN:BAKOR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ATG14 (synonyms: KIAA0831)
Protein Name(s)	Beclin 1-associated autophagy-related key regulator Barkor Autophagy-related protein 14-like protein Atg14L
External Links
UniProt	Q6ZNE5
EMBL	AB020638 AK131251 AK292810 AL158801 CH471061 BC109089 BC109090 BR000826
CCDS	CCDS32087.1
RefSeq	NP_055739.2
UniGene	Hs.414809
ProteinModelPortal	Q6ZNE5
BioGrid	116531
DIP	DIP-48651N
IntAct	Q6ZNE5
MINT	MINT-8304673
PhosphoSite	Q6ZNE5
DMDM	67461020
MaxQB	Q6ZNE5
PaxDb	Q6ZNE5
PRIDE	Q6ZNE5
Ensembl	ENST00000247178
GeneID	22863
KEGG	hsa:22863
UCSC	uc001xbw.2
CTD	22863
GeneCards	GC14M055834
HGNC	HGNC:19962
HPA	CAB037242 HPA053515
MIM	613515
neXtProt	NX_Q6ZNE5
PharmGKB	PA165478560
eggNOG	NOG236057
GeneTree	ENSGT00390000011854
HOVERGEN	HBG081828
InParanoid	Q6ZNE5
KO	K17889
OMA	CVQSGDF
OrthoDB	EOG7SV0WR
PhylomeDB	Q6ZNE5
TreeFam	TF323392
GenomeRNAi	22863
NextBio	43375
PRO	PR:Q6ZNE5
Proteomes	UP000005640
Bgee	Q6ZNE5
CleanEx	HS_KIAA0831
Genevestigator	Q6ZNE5
GO	GO:0005776 GO:0005930 GO:0005737 GO:0005789 GO:0097629 GO:0097632 GO:0005634 GO:0045335 GO:0034045 GO:0000045 GO:0008333 GO:0010508
InterPro	IPR018791
Pfam	PF10186

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005776	autophagosome	PMID:25686604^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016240	autophagosome membrane docking	PMID:25686604^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	PMID:25891078^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A1A4Y4	F		Seeded From UniProt	complete
involved_in	GO:0098780	response to mitochondrial depolarisation	PMID:23878393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:21062745^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:23878393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:23878393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q14457	P	has_regulation_target:(UniProtKB:Q14457) happens_during:(GO:0016236)	Seeded From UniProt	complete
involved_in	GO:0061635	regulation of protein complex stability	PMID:23878393^[3]	ECO:0000305	curator inference used in manual assertion	GO:0010608	P	has_regulation_target:(UniProtKB:Q14457)	Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	PMID:23878393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0098780)	Seeded From UniProt	complete
involved_in	GO:0010608	posttranscriptional regulation of gene expression	PMID:23878393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13501)\|has_regulation_target:(UniProtKB:Q14457)	Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	PMID:23878393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0009267)	Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CDJ3	C		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CDJ3	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CDJ3	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CDJ3	P		Seeded From UniProt	complete
part_of	GO:0097632	extrinsic component of phagophore assembly site membrane	PMID:21518905^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097629	extrinsic component of omegasome membrane	PMID:21518905^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	PMID:19270696^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CDJ3	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:19270696^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:19270696^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097632	extrinsic component of phagophore assembly site membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
part_of	GO:0097629	extrinsic component of omegasome membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
part_of	GO:0044233	mitochondria-associated endoplasmic reticulum membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261775 PANTHER:PTN001784663	C		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261775 PANTHER:PTN001784663	C		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
involved_in	GO:0008333	endosome to lysosome transport	PMID:22797916^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O95295	P		Seeded From UniProt	complete
involved_in	GO:0090207	regulation of triglyceride metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	C		Seeded From UniProt	complete
part_of	GO:0044233	mitochondria-associated endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	C		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	P		Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	P		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CDJ3 ensembl:ENSMUSP00000153718	P		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	Reactome:R-HSA-5682385	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	Reactome:R-HSA-1632852	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5679266 Reactome:R-HSA-5678315 Reactome:R-HSA-5678313 Reactome:R-HSA-1632857	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-5682385 Reactome:R-HSA-5679266 Reactome:R-HSA-5679205 Reactome:R-HSA-5672012	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0000421	autophagosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0022	C		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0221	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Diao, J et al. (2015) ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature 520 563-6 PubMed GONUTS page
↑ Chauhan, S et al. (2015) IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58 507-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Fogel, AI et al. (2013) Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol. Cell. Biol. 33 3675-88 PubMed GONUTS page
↑ Sun, Q et al. (2011) The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J. Biol. Chem. 286 185-91 PubMed GONUTS page
↑ ^5.0 ^5.1 Fan, W et al. (2011) Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L). Proc. Natl. Acad. Sci. U.S.A. 108 7769-74 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Matsunaga, K et al. (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 11 385-96 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kim, HJ et al. (2012) Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J. Cell. Sci. 125 4740-50 PubMed GONUTS page

[PMID:25686604-1] 1.0 ^1.1 Diao, J et al. (2015) ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature 520 563-6 PubMed GONUTS page

[PMID:25891078-2] Chauhan, S et al. (2015) IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58 507-21 PubMed GONUTS page

[PMID:23878393-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Fogel, AI et al. (2013) Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol. Cell. Biol. 33 3675-88 PubMed GONUTS page

[PMID:21062745-4] Sun, Q et al. (2011) The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J. Biol. Chem. 286 185-91 PubMed GONUTS page

[PMID:21518905-5] 5.0 ^5.1 Fan, W et al. (2011) Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L). Proc. Natl. Acad. Sci. U.S.A. 108 7769-74 PubMed GONUTS page

[PMID:19270696-6] 6.0 ^6.1 ^6.2 Matsunaga, K et al. (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 11 385-96 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22797916-8] Kim, HJ et al. (2012) Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J. Cell. Sci. 125 4740-50 PubMed GONUTS page

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HUMAN:BAKOR

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