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HUMAN:B7Z468
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CAST (ECO:0000313 with Ensembl:ENSP00000422677) | |
| Protein Name(s) | Calpastatin (ECO:0000313 with Ensembl:ENSP00000422677)
cDNA FLJ56102, highly similar to Homo sapiens calpastatin (CAST), transcript variant 8, mRNA (ECO:0000313 with EMBL:BAH12454.1) | |
| External Links | ||
| UniProt | B7Z468 | |
| EMBL | AC008906 AC020900 AC104125 KC877037 AK296919 | |
| RefSeq | XP_006714767.1 | |
| UniGene | Hs.436186 | |
| ProteinModelPortal | B7Z468 | |
| SMR | B7Z468 | |
| MEROPS | I27.001 | |
| MaxQB | B7Z468 | |
| Ensembl | ENST00000508608 | |
| GeneID | 831 | |
| KEGG | hsa:831 | |
| UCSC | uc011cuo.1 | |
| CTD | 831 | |
| HGNC | HGNC:1515 | |
| GeneTree | ENSGT00390000002993 | |
| HOGENOM | HOG000082405 | |
| HOVERGEN | HBG000183 | |
| KO | K04281 | |
| ChiTaRS | CAST | |
| GenomeRNAi | 831 | |
| NextBio | 35479401 | |
| ExpressionAtlas | B7Z468 | |
| GO | GO:0005737 | |
| InterPro | IPR026998 IPR001259 | |
| PANTHER | PTHR10077 | |
| Pfam | PF00748 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0010859 |
calcium-dependent cysteine-type endopeptidase inhibitor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097340 |
inhibition of cysteine-type endopeptidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000675 |
negative regulation of type B pancreatic cell apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097340 |
inhibition of cysteine-type endopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008546 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1098236 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0010859 |
calcium-dependent cysteine-type endopeptidase inhibitor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008546 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008546 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002020 |
protease binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008546 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990709 |
presynaptic active zone organization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004866 |
endopeptidase inhibitor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8868134 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004869 |
cysteine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Uemori, T et al. (1990) Characterization of a functional domain of human calpastatin. Biochem. Biophys. Res. Commun. 166 1485-93 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ 3.0 3.1 Hood, JL et al. (2003) Association of the calpain/calpastatin network with subcellular organelles. Biochem. Biophys. Res. Commun. 310 1200-12 PubMed GONUTS page
- ↑ Johnson, JD et al. (2004) RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J. Biol. Chem. 279 24794-802 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Mochida, S et al. (2016) SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression. Cell Rep 16 2901-2913 PubMed GONUTS page
- ↑ Mimori, T et al. (1995) Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases. Proc. Natl. Acad. Sci. U.S.A. 92 7267-71 PubMed GONUTS page
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