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HUMAN:B4GT7
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | B4GALT7 (synonyms: XGALT1) | |
| Protein Name(s) | Beta-1,4-galactosyltransferase 7
Beta-1,4-GalTase 7 Beta4Gal-T7 b4Gal-T7 UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7 Xylosylprotein 4-beta-galactosyltransferase Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I UDP-galactose:beta-xylose beta-1,4-galactosyltransferase XGPT XGalT-1 Xylosylprotein beta-1,4-galactosyltransferase | |
| External Links | ||
| UniProt | Q9UBV7 | |
| EMBL | AJ005382 AB028600 AF142675 AY358578 AK023506 CH471195 BC007317 BC062983 BC072403 | |
| CCDS | CCDS4429.1 | |
| RefSeq | NP_009186.1 | |
| UniGene | Hs.455109 | |
| PDB | 4IRP 4IRQ | |
| PDBsum | 4IRP 4IRQ | |
| ProteinModelPortal | Q9UBV7 | |
| SMR | Q9UBV7 | |
| BioGrid | 116441 | |
| STRING | 9606.ENSP00000029410 | |
| CAZy | GT7 | |
| PhosphoSite | Q9UBV7 | |
| DMDM | 13123990 | |
| MaxQB | Q9UBV7 | |
| PaxDb | Q9UBV7 | |
| PRIDE | Q9UBV7 | |
| DNASU | 11285 | |
| Ensembl | ENST00000029410 | |
| GeneID | 11285 | |
| KEGG | hsa:11285 | |
| UCSC | uc003mhy.3 | |
| CTD | 11285 | |
| GeneCards | GC05P177027 | |
| HGNC | HGNC:930 | |
| HPA | HPA042330 | |
| MIM | 130070 604327 | |
| neXtProt | NX_Q9UBV7 | |
| Orphanet | 75496 294049 | |
| PharmGKB | PA25229 | |
| eggNOG | NOG305756 | |
| GeneTree | ENSGT00760000119140 | |
| HOGENOM | HOG000286021 | |
| HOVERGEN | HBG050654 | |
| InParanoid | Q9UBV7 | |
| KO | K00733 | |
| OMA | FRFNRAS | |
| OrthoDB | EOG7C5M8P | |
| PhylomeDB | Q9UBV7 | |
| TreeFam | TF312834 | |
| BioCyc | MetaCyc:HS00459-MONOMER | |
| Reactome | REACT_121408 | |
| UniPathway | UPA00378 | |
| GeneWiki | B4GALT7 | |
| GenomeRNAi | 11285 | |
| NextBio | 42963 | |
| PRO | PR:Q9UBV7 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UBV7 | |
| CleanEx | HS_B4GALT7 | |
| ExpressionAtlas | Q9UBV7 | |
| Genevestigator | Q9UBV7 | |
| GO | GO:0005794 GO:0032580 GO:0000139 GO:0016021 GO:0003831 GO:0008378 GO:0030145 GO:0046525 GO:0005975 GO:0006464 GO:0030204 GO:0043206 GO:0006024 GO:0030203 GO:0048147 GO:0006487 GO:0006029 GO:0044281 | |
| Gene3D | 3.90.550.10 | |
| InterPro | IPR003859 IPR027791 IPR027995 IPR029044 | |
| PANTHER | PTHR19300 | |
| Pfam | PF02709 PF13733 | |
| PRINTS | PR02050 | |
| SUPFAM | SSF53448 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0000138 |
Golgi trans cisterna |
ECO:0000314 |
C |
Figure 7E |
complete | |||||
|
involved_in |
GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046525 |
xylosylprotein 4-beta-galactosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097435 |
supramolecular fiber organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008378 |
galactosyltransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008378 |
galactosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006487 |
protein N-linked glycosylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006029 |
proteoglycan metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006024 |
glycosaminoglycan biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003831 |
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046525 |
xylosylprotein 4-beta-galactosyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008378 |
galactosyltransferase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006464 |
cellular protein modification process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006029 |
proteoglycan metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046525 |
xylosylprotein 4-beta-galactosyltransferase activity |
Reactome:R-HSA-1889981 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030203 |
glycosaminoglycan metabolic process |
Reactome:R-HSA-1971475 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000139 |
Golgi membrane |
Reactome:R-HSA-1889981 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032580 |
Golgi cisterna membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Nilsson, T et al. (1991) The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization. EMBO J. 10 3567-75 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Seidler, DG et al. (2006) Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7). J. Mol. Med. 84 583-94 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Okajima, T et al. (1999) Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. J. Biol. Chem. 274 22915-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Tsutsui, Y et al. (2013) Crystal structures of β-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding. J. Biol. Chem. 288 31963-70 PubMed GONUTS page
- ↑ 5.0 5.1 Okajima, T et al. (1999) Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene. J. Biol. Chem. 274 28841-4 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Almeida, R et al. (1999) Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family. J. Biol. Chem. 274 26165-71 PubMed GONUTS page
c
g
- GO:0008378 ! galactosyltransferase activity
- GO:0030203 ! glycosaminoglycan metabolic process
- GO:0006024 ! glycosaminoglycan biosynthetic process
- GO:0016757 ! glycosyltransferase activity
- GO:0005794 ! Golgi apparatus
- GO:0032580 ! Golgi cisterna membrane
- GO:0000139 ! Golgi membrane
- GO:0000138 ! Golgi trans cisterna
m
p
