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HUMAN:AT1A3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ATP1A3
Protein Name(s) Sodium/potassium-transporting ATPase subunit alpha-3

Na(+)/K(+) ATPase alpha-3 subunit Na(+)/K(+) ATPase alpha(III) subunit Sodium pump subunit alpha-3

External Links
UniProt P13637
EMBL M37457
M37436
M37437
M37438
M37462
M37439
M37440
M37441
M37442
M37443
M37444
M37445
M37447
M37448
M37449
M37450
M37451
M37452
M37453
M37454
M37455
M37456
X12910
X12911
X12912
X12913
X12914
X12915
X12916
X12917
X12919
X12920
X12921
X12922
X12923
AK295078
AK296557
AC010616
BC009282
BC009394
BC015566
M28286
M28284
M28285
M28293
M28287
M35821
M35822
M28289
M28290
M28291
M28292
M27577
M27570
M27573
CCDS CCDS12594.1
CCDS58663.1
CCDS58664.1
PIR S00801
RefSeq NP_001243142.1
NP_001243143.1
NP_689509.1
UniGene Hs.515427
ProteinModelPortal P13637
SMR P13637
BioGrid 106968
IntAct P13637
MINT MINT-2857038
STRING 9606.ENSP00000302397
ChEMBL CHEMBL2095186
TCDB 3.A.3.1.1
PhosphoSite P13637
DMDM 116241260
MaxQB P13637
PaxDb P13637
PRIDE P13637
Ensembl ENST00000302102
ENST00000543770
ENST00000545399
GeneID 478
KEGG hsa:478
UCSC uc002osg.4
CTD 478
GeneCards GC19M042470
GeneReviews ATP1A3
HGNC HGNC:801
HPA CAB001988
MIM 128235
182350
601338
614820
neXtProt NX_P13637
Orphanet 2131
1171
71517
PharmGKB PA64
eggNOG COG0474
GeneTree ENSGT00760000119003
HOGENOM HOG000265622
HOVERGEN HBG004298
InParanoid P13637
KO K01539
OrthoDB EOG7327N0
PhylomeDB P13637
TreeFam TF312838
Reactome REACT_25149
ChiTaRS ATP1A3
GeneWiki ATP1A3
GenomeRNAi 478
NextBio 1981
PRO PR:P13637
Proteomes UP000005640
Bgee P13637
CleanEx HS_ATP1A3
ExpressionAtlas P13637
Genevestigator P13637
GO GO:0030424
GO:0044327
GO:0044326
GO:0005783
GO:0005794
GO:0016021
GO:0043209
GO:0005634
GO:0005886
GO:0005890
GO:0045202
GO:0031982
GO:0005524
GO:0051087
GO:0046872
GO:0005391
GO:1990239
GO:0008344
GO:0006754
GO:0086064
GO:0030007
GO:0071383
GO:0006883
GO:0034220
GO:0035235
GO:0007613
GO:0010107
GO:0042493
GO:1903416
GO:0036376
GO:0055085
GO:0008542
Gene3D 1.20.1110.10
2.70.150.10
3.40.1110.10
InterPro IPR006068
IPR004014
IPR023299
IPR018303
IPR023298
IPR008250
IPR023214
IPR005775
IPR001757
Pfam PF00689
PF00690
PF00122
PF00702
PRINTS PR00119
SMART SM00831
SUPFAM SSF56784
SSF81660
TIGRFAMs TIGR01106
TIGR01494
PROSITE PS00154

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0005391

sodium:potassium-exchanging ATPase activity

PMID:26224839[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005890

sodium:potassium-exchanging ATPase complex

PMID:26224839[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1904646

cellular response to amyloid-beta

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06687

P

  • occurs_in:(CL:0002608)
  • happens_during:(UBERON:0000066)
  • occurs_in:(GO:0016020)
  • causally_upstream_of:(GO:1903407)

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:26224839[1]

ECO:0000314

direct assay evidence used in manual assertion

F

  • occurs_in:(CL:0002608)
  • happens_during:(UBERON:0000066)|occurs_in(CL:1001611)
  • happens_during:(UBERON:0000066)

Seeded From UniProt

complete

involved_in

GO:1990535

neuron projection maintenance

PMID:26224839[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P05067

P

occurs_at:(CL:0002608)

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:26224839[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000598)
  • part_of:(UBERON:0001869)|part_of:(UBERON:0013693)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06687

C

  • part_of:(CL:0002608)
  • exists_during:(UBERON:0000066)|part_of(CL:1001611)
  • exists_during:(UBERON:0000066)

Seeded From UniProt

complete

part_of

GO:0032809

neuronal cell body membrane

PMID:26224839[1]

ECO:0000305

curator inference used in manual assertion

GO:0043025

C

  • part_of:(CL:0000598)
  • part_of:(UBERON:0001869)

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:26224839[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000598)
  • part_of:(UBERON:0001869)

Seeded From UniProt

complete

involved_in

GO:0071383

cellular response to steroid hormone stimulus

PMID:11546672[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

has_direct_input:(CHEBI:472805)

Seeded From UniProt

complete

enables

GO:1990239

steroid hormone binding

PMID:11546672[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

has_direct_input:(CHEBI:472805)

Seeded From UniProt

complete

involved_in

GO:1903416

response to glycoside

PMID:11546672[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1903561

extracellular vesicle

PMID:24769233[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001359)

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10636900[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P54709

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10636900[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P14415

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10636900[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05026

F

Seeded From UniProt

complete

enables

GO:0005391

sodium:potassium-exchanging ATPase activity

PMID:10636900[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005890

sodium:potassium-exchanging ATPase complex

PMID:10636900[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0036376

sodium ion export across plasma membrane

PMID:10636900[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030007

cellular potassium ion homeostasis

PMID:10636900[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1990573

potassium ion import across plasma membrane

PMID:10636900[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006883

cellular sodium ion homeostasis

PMID:10636900[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06687

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:15260953[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005890

sodium:potassium-exchanging ATPase complex

PMID:15260953[5]

ECO:0000305

curator inference used in manual assertion

GO:0005391

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15260953[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:15260953[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:15260953[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:15260953[5]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005391

sodium:potassium-exchanging ATPase activity

PMID:15260953[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0099520

ion antiporter activity involved in regulation of presynaptic membrane potential

PMID:10636900[4]

ECO:0006063

over expression analysis evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1990573

potassium ion import across plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000643123
RGD:2167
UniProtKB:P05024
UniProtKB:P50993

P

Seeded From UniProt

complete

involved_in

GO:0036376

sodium ion export across plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88107
PANTHER:PTN000643123
RGD:2167
UniProtKB:P05023
UniProtKB:P05024
UniProtKB:P13637
UniProtKB:P50993

P

Seeded From UniProt

complete

involved_in

GO:0030007

cellular potassium ion homeostasis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000643123
UniProtKB:P05023
UniProtKB:P05024
UniProtKB:P13637
UniProtKB:P50993

P

Seeded From UniProt

complete

involved_in

GO:0015991

ATP hydrolysis coupled proton transport

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000643123
RGD:2168

P

Seeded From UniProt

complete

involved_in

GO:0006883

cellular sodium ion homeostasis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88107
PANTHER:PTN000643123
UniProtKB:P05023
UniProtKB:P05024
UniProtKB:P13637
UniProtKB:P50993

P

Seeded From UniProt

complete

enables

GO:0005391

sodium:potassium-exchanging ATPase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002921
MGI:MGI:1351335
MGI:MGI:88105
PANTHER:PTN000643123
RGD:2167
RGD:2168
RGD:61952
UniProtKB:P05023
UniProtKB:P05024
UniProtKB:P13637
UniProtKB:P50993
WB:WBGene00001137
ZFIN:ZDB-GENE-001212-1

F

Seeded From UniProt

complete

involved_in

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005391

P

Seeded From UniProt

complete

involved_in

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005391

P

Seeded From UniProt

complete

involved_in

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005391

P

Seeded From UniProt

complete

involved_in

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005391

P

Seeded From UniProt

complete

involved_in

GO:0099505

regulation of presynaptic membrane potential

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0099520

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR023299

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005775

F

Seeded From UniProt

complete

involved_in

GO:0006813

potassium ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005775

P

Seeded From UniProt

complete

enables

GO:0008556

potassium-transporting ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005775

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001757
InterPro:IPR005775

C

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:26871627[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060075

regulation of resting membrane potential

PMID:26224839[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

occurs_in:(CL:0000540)

Seeded From UniProt

complete

involved_in

GO:0086064

cell communication by electrical coupling involved in cardiac conduction

PMID:19683723[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903779

regulation of cardiac conduction

Reactome:R-HSA-5578775

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

Reactome:R-HSA-936837

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-936897

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006813

potassium ion transport

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0633
UniProtKB-KW:KW-0740

P

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0739
UniProtKB-KW:KW-0740

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Ohnishi, T et al. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc. Natl. Acad. Sci. U.S.A. 112 E4465-74 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Wang, J et al. (2001) All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Am. J. Physiol., Cell Physiol. 281 C1336-43 PubMed GONUTS page
  3. ↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Crambert, G et al. (2000) Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J. Biol. Chem. 275 1976-86 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 de Carvalho Aguiar, P et al. (2004) Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. Neuron 43 169-75 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ De Strooper, B & Karran, E (2016) The Cellular Phase of Alzheimer's Disease. Cell 164 603-15 PubMed GONUTS page
  8. ↑ Barwe, SP et al. (2009) Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J. Mol. Cell. Cardiol. 47 552-60 PubMed GONUTS page
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