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HUMAN:ARL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ARL1
Protein Name(s) ADP-ribosylation factor-like protein 1
External Links
UniProt P40616
EMBL L28997
AF493887
BT007260
AK301701
AK311793
BX537387
AC063948
CH471054
BC007000
CCDS CCDS44958.1
RefSeq NP_001168.1
UniGene Hs.372616
Hs.732900
PDB 1UPT
4DCN
PDBsum 1UPT
4DCN
ProteinModelPortal P40616
SMR P40616
BioGrid 106893
IntAct P40616
MINT MINT-5002582
STRING 9606.ENSP00000261636
PhosphoSite P40616
DMDM 728888
MaxQB P40616
PaxDb P40616
PRIDE P40616
DNASU 400
Ensembl ENST00000261636
ENST00000536227
ENST00000551828
GeneID 400
KEGG hsa:400
UCSC uc001tib.3
CTD 400
GeneCards GC12M101786
HGNC HGNC:692
MIM 603425
neXtProt NX_P40616
PharmGKB PA24985
eggNOG COG1100
GeneTree ENSGT00770000120475
HOGENOM HOG000163691
HOVERGEN HBG002073
InParanoid P40616
KO K07942
OrthoDB EOG7JDR02
PhylomeDB P40616
TreeFam TF105461
EvolutionaryTrace P40616
GeneWiki ARL1
GenomeRNAi 400
NextBio 1677
PRO PR:P40616
Proteomes UP000005640
Bgee P40616
CleanEx HS_ARL1
ExpressionAtlas P40616
Genevestigator P40616
GO GO:0005737
GO:0070062
GO:0005794
GO:0000139
GO:0005802
GO:0008047
GO:0005525
GO:0003924
GO:0046872
GO:0019904
GO:0031584
GO:0007030
GO:0048193
GO:0006184
GO:0034067
GO:0042147
GO:0007264
GO:0009404
Gene3D 3.40.50.300
InterPro IPR027417
IPR005225
IPR024156
IPR006689
Pfam PF00025
PRINTS PR00328
SMART SM00177
SUPFAM SSF52540
TIGRFAMs TIGR00231
PROSITE PS51417

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005802

trans-Golgi network

PMID:17488291[1]

ECO:0000314

C

Figure 1 - colocalization study using antibodies

complete
CACAO 9830

part_of

GO:0005802

trans-Golgi network

PMID:17488291[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042147

retrograde transport, endosome to Golgi

PMID:19224922[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034067

protein localization to Golgi apparatus

PMID:19224922[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031584

activation of phospholipase D activity

PMID:9624189[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:14580338[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13439

F

Seeded From UniProt

complete

involved_in

GO:0009404

toxin metabolic process

PMID:9624189[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008047

enzyme activator activity

PMID:9624189[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007030

Golgi organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P61212

P

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P61212

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:19224922[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P61211

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:9624189[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:8798635[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:9624189[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99431
PANTHER:PTN000918181
SGD:S000000368
UniProtKB:P51823

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000918181
UniProtKB:P51823
WB:WBGene00000182

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000115
PANTHER:PTN000195580
SGD:S000000368
UniProtKB:P40616

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010348
MGI:MGI:1927136
MGI:MGI:1933161
MGI:MGI:99433
MGI:MGI:99434
MGI:MGI:99435
MGI:MGI:99436
PANTHER:PTN000917851
UniProtKB:P26990
UniProtKB:P49703
UniProtKB:P56559

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000115
MGI:MGI:99431
PANTHER:PTN000917851
RGD:621270
RGD:621587
UniProtKB:P18085
UniProtKB:P36406
UniProtKB:P40616
UniProtKB:P40617
UniProtKB:Q7KQL3
dictyBase:DDB_G0289173

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61211
ensembl:ENSMUSP00000111942

C

Seeded From UniProt

complete

involved_in

GO:0048193

Golgi vesicle transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61212
ensembl:ENSRNOP00000007623

P

Seeded From UniProt

complete

involved_in

GO:0007030

Golgi organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61212
ensembl:ENSRNOP00000007623

P

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61212
ensembl:ENSRNOP00000007623

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005225
InterPro:IPR006689

F

Seeded From UniProt

complete

part_of

GO:0032588

trans-Golgi network membrane

Reactome:R-HSA-6814682
Reactome:R-HSA-6814091
Reactome:R-HSA-6814086
Reactome:R-HSA-6811431

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-6814096
Reactome:R-HSA-6814094
Reactome:R-HSA-6814086

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Derby, MC et al. (2007) The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic 8 758-73 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Nishimoto-Morita, K et al. (2009) Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes. J. Biol. Chem. 284 10583-92 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Hong, JX et al. (1998) Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). J. Biol. Chem. 273 15872-6 PubMed GONUTS page
  4. ↑ Panic, B et al. (2003) Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. Mol. Cell 12 863-74 PubMed GONUTS page
  5. ↑ Ding, M et al. (1996) Characterization of a GTPase-activating protein that stimulates GTP hydrolysis by both ADP-ribosylation factor (ARF) and ARF-like proteins. Comparison to the ARD1 gap domain. J. Biol. Chem. 271 24005-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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