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HUMAN:ARFP2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ARFIP2 (synonyms: POR1) | |
| Protein Name(s) | Arfaptin-2
ADP-ribosylation factor-interacting protein 2 Partner of RAC1 Protein POR1 | |
| External Links | ||
| UniProt | P53365 | |
| EMBL | U52522 AK301856 AK304512 AC084337 CH471064 CH471064 BC000392 X97567 | |
| CCDS | CCDS55739.1 CCDS55740.1 CCDS7765.1 | |
| PIR | G02516 | |
| RefSeq | NP_001229784.1 NP_001229785.1 NP_036534.1 XP_005252897.1 | |
| UniGene | Hs.732203 Hs.75139 | |
| PDB | 1I49 1I4D 1I4L 1I4T 4DCN | |
| PDBsum | 1I49 1I4D 1I4L 1I4T 4DCN | |
| ProteinModelPortal | P53365 | |
| SMR | P53365 | |
| BioGrid | 117174 | |
| IntAct | P53365 | |
| MINT | MINT-1438715 | |
| STRING | 9606.ENSP00000254584 | |
| PhosphoSite | P53365 | |
| DMDM | 1703205 | |
| MaxQB | P53365 | |
| PaxDb | P53365 | |
| PRIDE | P53365 | |
| DNASU | 23647 | |
| Ensembl | ENST00000254584 ENST00000396777 ENST00000423813 ENST00000445086 | |
| GeneID | 23647 | |
| KEGG | hsa:23647 | |
| UCSC | uc001mdk.3 uc010ram.2 | |
| CTD | 23647 | |
| GeneCards | GC11M006496 | |
| HGNC | HGNC:17160 | |
| HPA | HPA038156 | |
| MIM | 601638 | |
| neXtProt | NX_P53365 | |
| PharmGKB | PA134879398 | |
| eggNOG | NOG302946 | |
| GeneTree | ENSGT00500000044828 | |
| HOGENOM | HOG000236308 | |
| HOVERGEN | HBG050564 | |
| InParanoid | P53365 | |
| OMA | HALGDTF | |
| OrthoDB | EOG7VQJD9 | |
| PhylomeDB | P53365 | |
| TreeFam | TF314945 | |
| ChiTaRS | ARFIP2 | |
| EvolutionaryTrace | P53365 | |
| GeneWiki | ARFIP2 | |
| GenomeRNAi | 23647 | |
| NextBio | 46467 | |
| PRO | PR:P53365 | |
| Proteomes | UP000005640 | |
| Bgee | P53365 | |
| CleanEx | HS_ARFIP2 | |
| ExpressionAtlas | P53365 | |
| Genevestigator | P53365 | |
| GO | GO:0005938 GO:0005737 GO:0005886 GO:0001726 GO:0032588 GO:0005525 GO:0030742 GO:0070273 GO:0048365 GO:0030036 GO:0006928 GO:0030032 GO:0031529 GO:0007264 | |
| Gene3D | 1.20.1270.60 | |
| InterPro | IPR027267 IPR010504 | |
| Pfam | PF06456 | |
| SMART | SM01015 | |
| PROSITE | PS50870 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030742 |
GTP-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030036 |
actin cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001726 |
ruffle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032588 |
trans-Golgi network membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000951698 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006886 |
intracellular protein transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000254123 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:894645 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005543 |
phospholipid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037884 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032588 |
trans-Golgi network membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007264 |
small GTPase mediated signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048365 |
Rac GTPase binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031529 |
ruffle organization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030032 |
lamellipodium assembly |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-6814094 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 D'Souza-Schorey, C et al. (1997) A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 16 5445-54 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Van Aelst, L et al. (1996) Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J. 15 3778-86 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ 6.0 6.1 Cruz-Garcia, D et al. (2013) Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. EMBO J. 32 1717-29 PubMed GONUTS page
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