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HUMAN:AP3B1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AP3B1 (synonyms: ADTB3A)
Protein Name(s) AP-3 complex subunit beta-1

Adaptor protein complex AP-3 subunit beta-1 Adaptor-related protein complex 3 subunit beta-1 Beta-3A-adaptin Clathrin assembly protein complex 3 beta-1 large chain

External Links
UniProt O00203
EMBL U91931
U81504
BX538041
AC024568
AC024578
AC104108
AC112197
BC038444
AF247736
CCDS CCDS4041.1
CCDS64186.1
PIR T50651
T50652
RefSeq NP_001258698.1
NP_003655.3
UniGene Hs.532091
ProteinModelPortal O00203
SMR O00203
BioGrid 114116
DIP DIP-24208N
IntAct O00203
MINT MINT-1538470
STRING 9606.ENSP00000255194
PhosphoSite O00203
MaxQB O00203
PaxDb O00203
PRIDE O00203
DNASU 8546
Ensembl ENST00000255194
ENST00000519295
GeneID 8546
KEGG hsa:8546
UCSC uc003kfj.4
CTD 8546
GeneCards GC05M077296
GeneReviews AP3B1
HGNC HGNC:566
HPA HPA038737
HPA045458
MIM 203300
603401
608233
neXtProt NX_O00203
Orphanet 183678
PharmGKB PA24857
eggNOG COG5096
GeneTree ENSGT00530000063546
HOGENOM HOG000033978
HOVERGEN HBG050519
InParanoid O00203
KO K12397
OMA FVPMKTH
OrthoDB EOG74R1QG
PhylomeDB O00203
TreeFam TF314605
Reactome REACT_19400
ChiTaRS AP3B1
GeneWiki AP3B1
GenomeRNAi 8546
NextBio 32018
PRO PR:O00203
Proteomes UP000005640
Bgee O00203
CleanEx HS_AP3B1
Genevestigator O00203
GO GO:0030123
GO:0030665
GO:0005794
GO:0005765
GO:0016020
GO:0030742
GO:0019903
GO:0008089
GO:0048490
GO:0048007
GO:0007596
GO:0006886
GO:0032438
GO:0051138
GO:0006622
Gene3D 1.25.10.10
InterPro IPR026740
IPR029394
IPR029390
IPR026739
IPR011989
IPR016024
IPR002553
PANTHER PTHR11134
Pfam PF01602
PF14796
PF14797
PIRSF PIRSF037096
SUPFAM SSF48371

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032438

melanosome organization

PMID:11452004[1]

ECO:0000315

P

In Fig. 5, normal melanosomes stain for tyrosinase. HPS-2 (AP-3 beta mutant) melanosomes lack tyrosinase.

complete
CACAO 2450

involved_in

GO:0032438

melanosome organization

PMID:11452004[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030742

GTP-dependent protein binding

PMID:22511774[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P57729

F

occurs_in:(GO:0016020)

Seeded From UniProt

complete

enables

GO:0030742

GTP-dependent protein binding

PMID:22511774[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13637

F

occurs_in:(GO:0016020)

Seeded From UniProt

complete

involved_in

GO:0048490

anterograde synaptic vesicle transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1T1

P

Seeded From UniProt

complete

involved_in

GO:0032438

melanosome organization

PMID:19841138[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019903

protein phosphatase binding

PMID:17622474[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92729

F

Seeded From UniProt

complete

involved_in

GO:0008089

anterograde axonal transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1T1

P

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

PMID:17897319[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016182

C

Seeded From UniProt

complete

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008089

C

Seeded From UniProt

complete

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0048490

C

Seeded From UniProt

complete

involved_in

GO:0051138

positive regulation of NK T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0048490

anterograde synaptic vesicle transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0048007

antigen processing and presentation, exogenous lipid antigen via MHC class Ib

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0019882

antigen processing and presentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0016182

synaptic vesicle budding from endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0008089

anterograde axonal transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0006622

protein targeting to lysosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1T1
ensembl:ENSMUSP00000022196

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002553
InterPro:IPR015151

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002553
InterPro:IPR015151
InterPro:IPR026739
InterPro:IPR026740

P

Seeded From UniProt

complete

part_of

GO:0030117

membrane coat

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002553

C

Seeded From UniProt

complete

part_of

GO:0030123

AP-3 adaptor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026740

C

Seeded From UniProt

complete

part_of

GO:0030131

clathrin adaptor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015151

C

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:9931340[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:9151686[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0030665

clathrin-coated vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0071

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Huizing, M et al. (2001) AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes. Mol. Biol. Cell 12 2075-85 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ 3.0 3.1 Bultema, JJ et al. (2012) BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles. J. Biol. Chem. 287 19550-63 PubMed GONUTS page
  4. ↑ Delevoye, C et al. (2009) AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis. J. Cell Biol. 187 247-64 PubMed GONUTS page
  5. ↑ Dong, H et al. (2007) Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2. Acta Biochim. Biophys. Sin. (Shanghai) 39 540-6 PubMed GONUTS page
  6. ↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
  7. ↑ Feng, L et al. (1999) The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness. Hum. Mol. Genet. 8 323-30 PubMed GONUTS page
  8. ↑ Simpson, F et al. (1997) Characterization of the adaptor-related protein complex, AP-3. J. Cell Biol. 137 835-45 PubMed GONUTS page
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