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HUMAN:AP1AR

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AP1AR (synonyms: C4orf16)
Protein Name(s) AP-1 complex-associated regulatory protein

2c18 Adaptor-related protein complex 1-associated regulatory protein Gamma-1-adaptin brefeldin A resistance protein GBAR Gamma-BAR Gamma-A1-adaptin and kinesin interactor Gadkin

External Links
UniProt Q63HQ0
EMBL AL136628
BX647702
AK315299
AC109347
BC009485
AF116612
CCDS CCDS3696.1
CCDS47125.1
RefSeq NP_001121898.1
NP_061039.3
UniGene Hs.435991
Hs.606210
ProteinModelPortal Q63HQ0
BioGrid 120667
IntAct Q63HQ0
MINT MINT-4724276
STRING 9606.ENSP00000274000
PhosphoSite Q63HQ0
DMDM 73917693
MaxQB Q63HQ0
PaxDb Q63HQ0
PRIDE Q63HQ0
DNASU 55435
Ensembl ENST00000274000
ENST00000309703
GeneID 55435
KEGG hsa:55435
UCSC uc003iaj.4
uc003iak.4
CTD 55435
GeneCards GC04P113153
HGNC HGNC:28808
HPA HPA035863
MIM 610851
neXtProt NX_Q63HQ0
PharmGKB PA165663153
eggNOG NOG74642
GeneTree ENSGT00390000002219
HOGENOM HOG000237335
InParanoid Q63HQ0
OMA SNNGEYQ
OrthoDB EOG7GXPC9
PhylomeDB Q63HQ0
TreeFam TF335676
ChiTaRS AP1AR
GeneWiki AP1AR
GenomeRNAi 55435
NextBio 35468210
PRO PR:Q63HQ0
Proteomes UP000005640
Bgee Q63HQ0
CleanEx HS_C4orf16
ExpressionAtlas Q63HQ0
Genevestigator Q63HQ0
GO GO:0005737
GO:0005769
GO:0005794
GO:0005770
GO:0005730
GO:0030133
GO:0035650
GO:0019894
GO:0034613
GO:2000146
GO:0001920
GO:1900025
GO:0015031
GO:0034315
GO:0048203

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030121

AP-1 adaptor complex

PMID:23657274[1]

ECO:0000315

C

Figure 1. Flavivirus production in AP-1-deficient cells.

complete
CACAO 8957

part_of

GO:0030133

transport vesicle

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048203

vesicle targeting, trans-Golgi to endosome

PMID:19706427[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0035650

AP-1 adaptor complex binding

PMID:19706427[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:19706427[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001920

negative regulation of receptor recycling

PMID:19706427[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048203

vesicle targeting, trans-Golgi to endosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002158628
UniProtKB:Q63HQ0

P

Seeded From UniProt

complete

enables

GO:0035650

AP-1 adaptor complex binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002158628
UniProtKB:Q63HQ0

F

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002158628
UniProtKB:Q63HQ0

F

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2384822
PANTHER:PTN002158628

C

Seeded From UniProt

complete

involved_in

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

PMID:22689987[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0048203

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048203

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048203

C

Seeded From UniProt

complete

involved_in

GO:2000146

negative regulation of cell motility

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PYF7
ensembl:ENSMUSP00000059669

P

Seeded From UniProt

complete

involved_in

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PYF7
ensembl:ENSMUSP00000059669

P

Seeded From UniProt

complete

involved_in

GO:0034613

cellular protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PYF7
ensembl:ENSMUSP00000059669

P

Seeded From UniProt

complete

involved_in

GO:0034315

regulation of Arp2/3 complex-mediated actin nucleation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PYF7
ensembl:ENSMUSP00000059669

P

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PYF7
ensembl:ENSMUSP00000059669

C

Seeded From UniProt

complete

involved_in

GO:0034315

regulation of Arp2/3 complex-mediated actin nucleation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031483

P

Seeded From UniProt

complete

enables

GO:0035650

AP-1 adaptor complex binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031483

F

Seeded From UniProt

complete

involved_in

GO:0048203

vesicle targeting, trans-Golgi to endosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031483

P

Seeded From UniProt

complete

involved_in

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031483

P

Seeded From UniProt

complete

involved_in

GO:2000146

negative regulation of cell motility

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031483

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0094

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0152

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Agrawal, T et al. (2013) Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle. Sci Rep 3 1813 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Schmidt, MR et al. (2009) Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. Proc. Natl. Acad. Sci. U.S.A. 106 15344-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Maritzen, T et al. (2012) Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc. Natl. Acad. Sci. U.S.A. 109 10382-7 PubMed GONUTS page
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