GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:AOC3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | AOC3 (synonyms: VAP1) | |
| Protein Name(s) | Membrane primary amine oxidase
Copper amine oxidase HPAO Semicarbazide-sensitive amine oxidase SSAO Vascular adhesion protein 1 VAP-1 | |
| External Links | ||
| UniProt | Q16853 | |
| EMBL | U39447 AF067406 AB050502 JX020506 AK025727 AK315129 DQ143944 AC016889 BC050549 | |
| CCDS | CCDS11444.1 CCDS62198.1 CCDS74071.1 | |
| PIR | JC5234 | |
| RefSeq | NP_001264660.1 NP_001264661.1 NP_003725.1 | |
| UniGene | Hs.198241 | |
| PDB | 1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY | |
| PDBsum | 1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY | |
| ProteinModelPortal | Q16853 | |
| SMR | Q16853 | |
| BioGrid | 114192 | |
| IntAct | Q16853 | |
| STRING | 9606.ENSP00000312326 | |
| BindingDB | Q16853 | |
| ChEMBL | CHEMBL3437 | |
| DrugBank | DB01275 DB00780 | |
| GuidetoPHARMACOLOGY | 2767 | |
| DMDM | 2501336 | |
| PaxDb | Q16853 | |
| PeptideAtlas | Q16853 | |
| PRIDE | Q16853 | |
| Ensembl | ENST00000308423 ENST00000591562 ENST00000613571 ENST00000617500 | |
| GeneID | 8639 | |
| KEGG | hsa:8639 | |
| UCSC | uc002ibv.4 | |
| CTD | 8639 | |
| GeneCards | GC17P041003 | |
| HGNC | HGNC:550 | |
| HPA | CAB025797 HPA000980 | |
| MIM | 603735 | |
| neXtProt | NX_Q16853 | |
| PharmGKB | PA24840 | |
| eggNOG | COG3733 | |
| GeneTree | ENSGT00510000046461 | |
| HOGENOM | HOG000233919 | |
| HOVERGEN | HBG004164 | |
| InParanoid | Q16853 | |
| KO | K00276 | |
| OMA | YVSETTH | |
| OrthoDB | EOG7353W8 | |
| PhylomeDB | Q16853 | |
| TreeFam | TF314750 | |
| SABIO-RK | Q16853 | |
| EvolutionaryTrace | Q16853 | |
| GeneWiki | AOC3 | |
| GenomeRNAi | 8639 | |
| NextBio | 32389 | |
| PRO | PR:Q16853 | |
| Proteomes | UP000005640 | |
| Bgee | Q16853 | |
| CleanEx | HS_AOC3 | |
| ExpressionAtlas | Q16853 | |
| Genevestigator | Q16853 | |
| GO | GO:0009986 GO:0005737 GO:0016021 GO:0005902 GO:0005886 GO:0052595 GO:0052594 GO:0005509 GO:0005261 GO:0005507 GO:0052596 GO:0008131 GO:0046982 GO:0042803 GO:0048038 GO:0052593 GO:0009308 GO:0098655 GO:0006812 GO:0007155 GO:0006954 GO:0046677 | |
| Gene3D | 2.70.98.20 3.10.450.40 | |
| InterPro | IPR000269 IPR015798 IPR016182 IPR015800 IPR015801 IPR015802 | |
| PANTHER | PTHR10638 | |
| Pfam | PF01179 PF02727 PF02728 | |
| PRINTS | PR00766 | |
| SUPFAM | SSF49998 SSF54416 | |
| PROSITE | PS01164 PS01165 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005769 |
early endosome |
ECO:0000314 |
C |
Figure 3A. |
complete | |||||
| GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
C |
Supplemental figures 3A and 3B. |
complete | |||||
| GO:0005794 |
Golgi apparatus |
ECO:0000314 |
C |
Supplementary Fig. 3 a,b. |
complete | |||||
| GO:0008131 |
primary amine oxidase activity |
ECO:0000314 |
F |
Figure 1. |
complete | |||||
|
enables |
GO:0008131 |
primary amine oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005769 |
early endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048038 |
quinone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046677 |
response to antibiotic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009308 |
amine metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008131 |
primary amine oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008131 |
primary amine oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008131 |
primary amine oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005902 |
microvillus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005507 |
copper ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902283 |
negative regulation of primary amine oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0008131 |
primary amine oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902283 |
negative regulation of primary amine oxidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067358 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046677 |
response to antibiotic |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067358 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009308 |
amine metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067313 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067340 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067358 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067358 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005769 |
early endosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067358 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005507 |
copper ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG13140 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005507 |
copper ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000269 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009308 |
amine metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000269 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048038 |
quinone binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000269 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000269 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0052594 |
aminoacetone:oxygen oxidoreductase(deaminating) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052593 |
tryptamine:oxygen oxidoreductase (deaminating) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052595 |
aliphatic-amine oxidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052596 |
phenethylamine:oxygen oxidoreductase (deaminating) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
Reactome:R-HSA-211945 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-5696183 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Weston, CJ et al. (2013) Cellular localization and trafficking of vascular adhesion protein-1 as revealed by an N-terminal GFP fusion protein. J Neural Transm (Vienna) 120 951-61 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Smith, DJ et al. (1998) Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. J. Exp. Med. 188 17-27 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Kaitaniemi, S et al. (2013) Functional modulation of vascular adhesion protein-1 by a novel splice variant. PLoS ONE 8 e54151 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 McGrath, AP et al. (2009) Structure and inhibition of human diamine oxidase. Biochemistry 48 9810-22 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
o
- GO:0052594 ! obsolete aminoacetone:oxygen oxidoreductase(deaminating) activity
- GO:1902283 ! obsolete negative regulation of primary amine oxidase activity
- GO:0055114 ! obsolete oxidation-reduction process
- GO:0052596 ! obsolete phenethylamine:oxygen oxidoreductase (deaminating) activity
- GO:0052593 ! obsolete tryptamine:oxygen oxidoreductase (deaminating) activity
- GO:0016491 ! oxidoreductase activity
p
