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HUMAN:AOC3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AOC3 (synonyms: VAP1)
Protein Name(s) Membrane primary amine oxidase

Copper amine oxidase HPAO Semicarbazide-sensitive amine oxidase SSAO Vascular adhesion protein 1 VAP-1

External Links
UniProt Q16853
EMBL U39447
AF067406
AB050502
JX020506
AK025727
AK315129
DQ143944
AC016889
BC050549
CCDS CCDS11444.1
CCDS62198.1
CCDS74071.1
PIR JC5234
RefSeq NP_001264660.1
NP_001264661.1
NP_003725.1
UniGene Hs.198241
PDB 1PU4
1US1
2C10
2C11
2Y73
2Y74
3ALA
4BTW
4BTX
4BTY
PDBsum 1PU4
1US1
2C10
2C11
2Y73
2Y74
3ALA
4BTW
4BTX
4BTY
ProteinModelPortal Q16853
SMR Q16853
BioGrid 114192
IntAct Q16853
STRING 9606.ENSP00000312326
BindingDB Q16853
ChEMBL CHEMBL3437
DrugBank DB01275
DB00780
GuidetoPHARMACOLOGY 2767
DMDM 2501336
PaxDb Q16853
PeptideAtlas Q16853
PRIDE Q16853
Ensembl ENST00000308423
ENST00000591562
ENST00000613571
ENST00000617500
GeneID 8639
KEGG hsa:8639
UCSC uc002ibv.4
CTD 8639
GeneCards GC17P041003
HGNC HGNC:550
HPA CAB025797
HPA000980
MIM 603735
neXtProt NX_Q16853
PharmGKB PA24840
eggNOG COG3733
GeneTree ENSGT00510000046461
HOGENOM HOG000233919
HOVERGEN HBG004164
InParanoid Q16853
KO K00276
OMA YVSETTH
OrthoDB EOG7353W8
PhylomeDB Q16853
TreeFam TF314750
SABIO-RK Q16853
EvolutionaryTrace Q16853
GeneWiki AOC3
GenomeRNAi 8639
NextBio 32389
PRO PR:Q16853
Proteomes UP000005640
Bgee Q16853
CleanEx HS_AOC3
ExpressionAtlas Q16853
Genevestigator Q16853
GO GO:0009986
GO:0005737
GO:0016021
GO:0005902
GO:0005886
GO:0052595
GO:0052594
GO:0005509
GO:0005261
GO:0005507
GO:0052596
GO:0008131
GO:0046982
GO:0042803
GO:0048038
GO:0052593
GO:0009308
GO:0098655
GO:0006812
GO:0007155
GO:0006954
GO:0046677
Gene3D 2.70.98.20
3.10.450.40
InterPro IPR000269
IPR015798
IPR016182
IPR015800
IPR015801
IPR015802
PANTHER PTHR10638
Pfam PF01179
PF02727
PF02728
PRINTS PR00766
SUPFAM SSF49998
SSF54416
PROSITE PS01164
PS01165

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005769

early endosome

PMID:23474851[1]

ECO:0000314

C

Figure 3A.

complete
CACAO 8414

GO:0005783

endoplasmic reticulum

PMID:23474851[1]

ECO:0000314

C

Supplemental figures 3A and 3B.

complete
CACAO 8415

GO:0005794

Golgi apparatus

PMID:23474851[1]

ECO:0000314

C

Supplementary Fig. 3 a,b.

complete
CACAO 8416

GO:0008131

primary amine oxidase activity

PMID:23474851[1]

ECO:0000314

F

Figure 1.

complete
CACAO 8417

enables

GO:0008131

primary amine oxidase activity

PMID:23474851[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:23474851[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:23474851[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:23474851[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0048038

quinone binding

PMID:9653080[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:23349812[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q16853

F

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

PMID:19764817[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:9653080[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:23349812[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:9653080[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009308

amine metabolic process

PMID:9653080[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008131

primary amine oxidase activity

PMID:23349812[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008131

primary amine oxidase activity

PMID:19764817[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008131

primary amine oxidase activity

PMID:9653080[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:9653080[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

PMID:23349812[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9653080[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:23349812[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:19764817[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

PMID:19764817[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1902283

negative regulation of primary amine oxidase activity

PMID:23349812[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0008131

primary amine oxidase activity

PMID:23349812[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1902283

negative regulation of primary amine oxidase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067358
UniProtKB:Q16853

P

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067358
UniProtKB:Q16853

P

Seeded From UniProt

complete

involved_in

GO:0009308

amine metabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067313
UniProtKB:Q16853

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067340
UniProtKB:P19801
UniProtKB:Q16853
UniProtKB:Q9TRC7

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067358
UniProtKB:Q16853

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067358
UniProtKB:Q16853

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067358
UniProtKB:Q16853

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13140
PANTHER:PTN000067313
UniProtKB:P19801
UniProtKB:Q16853

F

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000269
InterPro:IPR015798
InterPro:IPR015800
InterPro:IPR015802
InterPro:IPR016182
InterPro:IPR036460

F

Seeded From UniProt

complete

involved_in

GO:0009308

amine metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000269
InterPro:IPR015798
InterPro:IPR015800
InterPro:IPR015802
InterPro:IPR016182
InterPro:IPR036460

P

Seeded From UniProt

complete

enables

GO:0048038

quinone binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000269
InterPro:IPR015798
InterPro:IPR015800
InterPro:IPR015802
InterPro:IPR016182
InterPro:IPR036460

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000269
InterPro:IPR015798
InterPro:IPR015800
InterPro:IPR015802
InterPro:IPR016182
InterPro:IPR036460

P

Seeded From UniProt

complete

enables

GO:0052594

aminoacetone:oxygen oxidoreductase(deaminating) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.4.3.21

F

Seeded From UniProt

complete

enables

GO:0052593

tryptamine:oxygen oxidoreductase (deaminating) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.4.3.21

F

Seeded From UniProt

complete

enables

GO:0052595

aliphatic-amine oxidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.4.3.21

F

Seeded From UniProt

complete

enables

GO:0052596

phenethylamine:oxygen oxidoreductase (deaminating) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.4.3.21

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:9653080[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:9653080[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006805

xenobiotic metabolic process

Reactome:R-HSA-211945

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-5696183

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Weston, CJ et al. (2013) Cellular localization and trafficking of vascular adhesion protein-1 as revealed by an N-terminal GFP fusion protein. J Neural Transm (Vienna) 120 951-61 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Smith, DJ et al. (1998) Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. J. Exp. Med. 188 17-27 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Kaitaniemi, S et al. (2013) Functional modulation of vascular adhesion protein-1 by a novel splice variant. PLoS ONE 8 e54151 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 McGrath, AP et al. (2009) Structure and inhibition of human diamine oxidase. Biochemistry 48 9810-22 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page