GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:AMRA1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AMBRA1 (synonyms: KIAA1736)
Protein Name(s) Activating molecule in BECN1-regulated autophagy protein 1
External Links
UniProt Q9C0C7
EMBL DQ870924
AB051523
AK000301
AK023197
AL834190
AC024293
AC115097
AC116021
AC127035
CH471064
CH471064
CH471064
BC045609
CCDS CCDS31475.1
CCDS73281.1
RefSeq NP_001254711.1
NP_001254712.1
NP_001287660.1
NP_060219.2
XP_005253066.1
XP_005253068.1
XP_005253071.1
XP_006718322.1
UniGene Hs.654644
ProteinModelPortal Q9C0C7
BioGrid 120765
DIP DIP-53597N
IntAct Q9C0C7
MINT Q9C0C7
STRING 9606.ENSP00000318313
iPTMnet Q9C0C7
PhosphoSitePlus Q9C0C7
BioMuta AMBRA1
DMDM 166215833
EPD Q9C0C7
MaxQB Q9C0C7
PaxDb Q9C0C7
PeptideAtlas Q9C0C7
PRIDE Q9C0C7
ProteomicsDB 79999
80000
80001
80002
80003
Ensembl ENST00000314845
ENST00000458649
ENST00000528950
ENST00000534300
GeneID 55626
KEGG hsa:55626
UCSC uc001ncu.3
CTD 55626
DisGeNET 55626
EuPathDB HostDB:ENSG00000110497.14
GeneCards AMBRA1
H-InvDB HIX0009602
HGNC HGNC:25990
HPA CAB017825
HPA038535
MIM 611359
neXtProt NX_Q9C0C7
OpenTargets ENSG00000110497
PharmGKB PA162376307
eggNOG ENOG410IQ11
ENOG410ZUDQ
GeneTree ENSGT00390000016223
HOGENOM HOG000033925
HOVERGEN HBG103818
InParanoid Q9C0C7
KO K17985
OMA HPSTEHM
OrthoDB EOG091G032K
PhylomeDB Q9C0C7
TreeFam TF328981
Reactome R-HSA-1632852
SignaLink Q9C0C7
SIGNOR Q9C0C7
ChiTaRS AMBRA1
GenomeRNAi 55626
PRO PR:Q9C0C7
Proteomes UP000005640
Bgee ENSG00000110497
CleanEx HS_AMBRA1
ExpressionAtlas Q9C0C7
Genevisible Q9C0C7
GO GO:0005776
GO:0005930
GO:0005737
GO:0005829
GO:0005741
GO:0005739
GO:0048471
GO:0045335
GO:0051020
GO:0031625
GO:0000045
GO:0000422
GO:0030154
GO:0009267
GO:0016236
GO:0000423
GO:0010667
GO:0008285
GO:0043524
GO:0021915
GO:0010508
GO:0043552
GO:0098780
Gene3D 2.130.10.10
InterPro IPR015943
IPR001680
IPR019775
IPR017986
IPR036322
SMART SM00320
SUPFAM SSF50978
PROSITE PS00678
PS50082
PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0051020

GTPase binding

PMID:25891078[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A1A4Y4

F

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:25215947[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:25215947[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60260

P

Seeded From UniProt

complete

involved_in

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

PMID:21753002[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:25215947[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:25215947[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000423

mitophagy

PMID:25215947[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0098780)

Seeded From UniProt

complete

involved_in

GO:0000423

mitophagy

PMID:21753002[3]

ECO:0000314

direct assay evidence used in manual assertion

P

part_of:(GO:0098780)

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:25215947[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q99MQ3

P

Seeded From UniProt

complete

colocalizes_with

GO:0005739

mitochondrion

PMID:21753002[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21753002[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001891)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:21753002[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60260

F

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:A2AH22

C

Seeded From UniProt

complete

involved_in

GO:0098780

response to mitochondrial depolarisation

PMID:25215947[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9BXM7

P

Seeded From UniProt

complete

involved_in

GO:0098780

response to mitochondrial depolarisation

PMID:21753002[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2443564
PANTHER:PTN000524260

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:17589504[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045335

phagocytic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2AH22
ensembl:ENSMUSP00000049258

C

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2AH22
ensembl:ENSMUSP00000049258

P

Seeded From UniProt

complete

involved_in

GO:0021915

neural tube development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2AH22
ensembl:ENSMUSP00000049258

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2AH22
ensembl:ENSMUSP00000049258

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2AH22
ensembl:ENSMUSP00000049258

P

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2AH22
ensembl:ENSMUSP00000049258

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2AH22
ensembl:ENSMUSP00000049258

C

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LNQ2
ensembl:ENSRNOP00000039742

P

Seeded From UniProt

complete

involved_in

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LNQ2
ensembl:ENSRNOP00000039742

P

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LNQ2
ensembl:ENSRNOP00000039742

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LNQ2
ensembl:ENSRNOP00000039742

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:21753002[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-1632852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5678315
Reactome:R-HSA-5678313
Reactome:R-HSA-1632857
Reactome:R-HSA-1632843

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0023

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Chauhan, S et al. (2015) IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58 507-21 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Strappazzon, F et al. (2015) AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Differ. 22 419-32 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Van Humbeeck, C et al. (2011) Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 31 10249-61 PubMed GONUTS page
  4. ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Fimia, GM et al. (2007) Ambra1 regulates autophagy and development of the nervous system. Nature 447 1121-5 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:AMRA1&oldid=5945113"