HUMAN:AMD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PAM
Protein Name(s)	Peptidyl-glycine alpha-amidating monooxygenase PAM Peptidylglycine alpha-hydroxylating monooxygenase PHM Peptidyl-alpha-hydroxyglycine alpha-amidating lyase Peptidylamidoglycolate lyase PAL
External Links
UniProt	P19021
EMBL	M37721 S75037 S75038 AB095007 AK290158 BT007419 AC008779 AC010250 AC113373 CH471086 BC018127 AF010472 AF035320
CCDS	CCDS4092.1 CCDS4093.1 CCDS4094.1 CCDS43348.1 CCDS54885.1
PIR	A35477
RefSeq	NP_000910.2 NP_001170777.1 NP_620121.1 NP_620176.1 NP_620177.1 XP_006714695.1 XP_006714696.1 XP_006714697.1 XP_006714701.1 XP_006714703.1
UniGene	Hs.369430
ProteinModelPortal	P19021
SMR	P19021
BioGrid	111101
IntAct	P19021
BindingDB	P19021
ChEMBL	CHEMBL2544
DrugBank	DB00126
PhosphoSite	P19021
DMDM	23503036
MaxQB	P19021
PaxDb	P19021
PRIDE	P19021
DNASU	5066
Ensembl	ENST00000304400 ENST00000346918 ENST00000348126 ENST00000438793 ENST00000455264
GeneID	5066
KEGG	hsa:5066
UCSC	uc003kns.3 uc003knt.3 uc003knu.3 uc003knv.3 uc003knw.3
CTD	5066
GeneCards	GC05P102089
HGNC	HGNC:8596
HPA	CAB026119 HPA042260
MIM	170270
neXtProt	NX_P19021
PharmGKB	PA32926
eggNOG	COG3391
GeneTree	ENSGT00730000111058
HOVERGEN	HBG004218
InParanoid	P19021
KO	K00504 K18200
OMA	TVHHMLL
OrthoDB	EOG70ZZNT
PhylomeDB	P19021
TreeFam	TF320698
SignaLink	P19021
ChiTaRS	PAM
GeneWiki	Peptidylglycine_alpha-amidating_monooxygenase
GenomeRNAi	5066
NextBio	19512
PRO	PR:P19021
Proteomes	UP000005640
Bgee	P19021
CleanEx	HS_PAM
ExpressionAtlas	P19021
Genevestigator	P19021
GO	GO:0070062 GO:0016021 GO:0016020 GO:0005507 GO:0031418 GO:0004598 GO:0004504 GO:0008270 GO:0001519
Gene3D	2.120.10.30 2.60.120.230 2.60.120.310
InterPro	IPR011042 IPR014784 IPR020611 IPR014783 IPR000323 IPR001258 IPR013017 IPR000720 IPR008977
Pfam	PF01082 PF01436
PRINTS	PR00790
SUPFAM	SSF49742
PROSITE	PS00084 PS00085 PS51125

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0062112	fatty acid primary amide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14925	P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10731	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14925	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14925	F		Seeded From UniProt	complete
enables	GO:0004598	peptidylamidoglycolate lyase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14925	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:12699694^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004598	peptidylamidoglycolate lyase activity	PMID:12699694^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000948)\|activated_by(CHEBI:29105)	Seeded From UniProt	complete
enables	GO:0004504	peptidylglycine monooxygenase activity	PMID:2357221^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004504	peptidylglycine monooxygenase activity	PMID:12699694^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0001519	peptide amidation	PMID:2357221^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001519	peptide amidation	PMID:12699694^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000073732 RGD:3252	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262728 PANTHER:PTN000840899	C		Seeded From UniProt	complete
enables	GO:0004598	peptidylamidoglycolate lyase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262728 PANTHER:PTN000840873 RGD:3252 UniProtKB:P19021	F		Seeded From UniProt	complete
enables	GO:0004504	peptidylglycine monooxygenase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000073732 RGD:3252 UniProtKB:P19021	F		Seeded From UniProt	complete
involved_in	GO:0001519	peptide amidation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000840873 RGD:3252 UniProtKB:P19021	P		Seeded From UniProt	complete
involved_in	GO:0062112	fatty acid primary amide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0050708	regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
involved_in	GO:0022602	ovulation cycle process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	F		Seeded From UniProt	complete
involved_in	GO:0019538	protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0018032	protein amidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
involved_in	GO:0009404	toxin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0009268	response to pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	F		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0006518	peptide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	F		Seeded From UniProt	complete
enables	GO:0004598	peptidylamidoglycolate lyase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	F		Seeded From UniProt	complete
enables	GO:0004504	peptidylglycine monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	F		Seeded From UniProt	complete
involved_in	GO:0001676	long-chain fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
involved_in	GO:0001519	peptide amidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14925 ensembl:ENSRNOP00000046774	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000720 InterPro:IPR008977	F		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR036939	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR036939	F		Seeded From UniProt	complete
involved_in	GO:0006518	peptide metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000720	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000720	C		Seeded From UniProt	complete
enables	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR014783 InterPro:IPR014784 InterPro:IPR020611 InterPro:IPR036939	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR014783 InterPro:IPR014784 InterPro:IPR020611 InterPro:IPR036939	P		Seeded From UniProt	complete
enables	GO:0004598	peptidylamidoglycolate lyase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.3.2.5	F		Seeded From UniProt	complete
enables	GO:0004504	peptidylglycine monooxygenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.17.3	F		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0031418	L-ascorbic acid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0847	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0030658	transport vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0245	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Satani, M et al. (2003) Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase. Protein Expr. Purif. 28 293-302 PubMed GONUTS page
↑ ^5.0 ^5.1 Glauder, J et al. (1990) Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells. Biochem. Biophys. Res. Commun. 169 551-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23533145-1] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19199708-3] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:12699694-4] 4.0 ^4.1 ^4.2 ^4.3 Satani, M et al. (2003) Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase. Protein Expr. Purif. 28 293-302 PubMed GONUTS page

[PMID:2357221-5] 5.0 ^5.1 Glauder, J et al. (1990) Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells. Biochem. Biophys. Res. Commun. 169 551-8 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

HUMAN:AMD

Contents

Annotations

Notes

References

c

e

f

h

i

l

m

n

o

p

r

s

t

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools