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HUMAN:ALDH2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ALDH2 (synonyms: ALDM) | |
| Protein Name(s) | Aldehyde dehydrogenase, mitochondrial
ALDH class 2 ALDH-E2 ALDHI | |
| External Links | ||
| UniProt | P05091 | |
| EMBL | X05409 Y00109 M20456 M20444 M20445 M20446 M20447 M20448 M20449 M20450 M20451 M20452 M20453 M20454 AY621070 CR456991 AK301375 AC002996 AC003029 BC002967 BC071839 K03001 M26760 M54931 | |
| CCDS | CCDS55885.1 CCDS9155.1 | |
| PIR | A29975 | |
| RefSeq | NP_000681.2 NP_001191818.1 | |
| UniGene | Hs.604551 | |
| PDB | 1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG | |
| PDBsum | 1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG | |
| DisProt | DP00383 | |
| ProteinModelPortal | P05091 | |
| SMR | P05091 | |
| BioGrid | 106719 | |
| DIP | DIP-40262N | |
| IntAct | P05091 | |
| MINT | MINT-1368102 | |
| STRING | 9606.ENSP00000261733 | |
| BindingDB | P05091 | |
| ChEMBL | CHEMBL1935 | |
| DrugBank | DB01612 DB06770 DB00822 DB00536 DB00435 DB00727 | |
| GuidetoPHARMACOLOGY | 2595 | |
| PhosphoSite | P05091 | |
| DMDM | 118504 | |
| REPRODUCTION-2DPAGE | IPI00006663 P05091 | |
| UCD-2DPAGE | P05091 | |
| MaxQB | P05091 | |
| PaxDb | P05091 | |
| PeptideAtlas | P05091 | |
| PRIDE | P05091 | |
| DNASU | 217 | |
| Ensembl | ENST00000261733 ENST00000416293 | |
| GeneID | 217 | |
| KEGG | hsa:217 | |
| UCSC | uc001tst.3 | |
| CTD | 217 | |
| GeneCards | GC12P112205 | |
| HGNC | HGNC:404 | |
| HPA | HPA051065 | |
| MIM | 100650 610251 | |
| neXtProt | NX_P05091 | |
| PharmGKB | PA24696 | |
| eggNOG | COG1012 | |
| GeneTree | ENSGT00760000118999 | |
| HOGENOM | HOG000271505 | |
| HOVERGEN | HBG000097 | |
| InParanoid | P05091 | |
| KO | K00128 | |
| OMA | HLIMEAA | |
| OrthoDB | EOG7PS1F7 | |
| PhylomeDB | P05091 | |
| TreeFam | TF300455 | |
| BioCyc | MetaCyc:MONOMER66-302 | |
| Reactome | REACT_15532 REACT_34 | |
| SABIO-RK | P05091 | |
| UniPathway | UPA00780 | |
| ChiTaRS | ALDH2 | |
| EvolutionaryTrace | P05091 | |
| GeneWiki | ALDH2 | |
| GenomeRNAi | 217 | |
| NextBio | 878 | |
| PRO | PR:P05091 | |
| Proteomes | UP000005640 | |
| Bgee | P05091 | |
| CleanEx | HS_ALDH2 | |
| ExpressionAtlas | P05091 | |
| Genevestigator | P05091 | |
| GO | GO:0070062 GO:0005759 GO:0004029 GO:0004030 GO:0009055 GO:0006066 GO:0005975 GO:0006068 GO:0006069 GO:0042136 GO:0044281 GO:0007268 GO:0006805 | |
| Gene3D | 3.40.309.10 3.40.605.10 | |
| InterPro | IPR016161 IPR016163 IPR016160 IPR029510 IPR016162 IPR015590 | |
| Pfam | PF00171 | |
| SUPFAM | SSF53720 | |
| PROSITE | PS00070 PS00687 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0051287 |
NAD binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0012036 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022900 |
electron transport chain |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0009055 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016620 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043878 |
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006066 |
alcohol metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004030 |
aldehyde dehydrogenase [NAD(P)+] activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009055 |
electron transfer activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006069 |
ethanol oxidation |
Reactome:R-HSA-71384 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-71723 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006068 |
ethanol catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00780 |
P |
Seeded From UniProt |
complete | ||
| GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000314 |
F |
Table 1, The gels were stained for ALDH activity with an agar overlay containing propionaldehyde or benzaldehyde |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bateman, OA et al. (2003) Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry 42 4349-56 PubMed GONUTS page
- ↑ 2.0 2.1 Hopkinson, DA et al. () Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH). Alcohol 2 73-8 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Yoshida, A (1992) Molecular genetics of human aldehyde dehydrogenase. Pharmacogenetics 2 139-47 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Xiao, Q et al. (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J. Clin. Invest. 98 2027-32 PubMed GONUTS page
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