GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:AL1A1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ALDH1A1 (synonyms: ALDC, ALDH1, PUMB1) | |
| Protein Name(s) | Retinal dehydrogenase 1
RALDH 1 RalDH1 ALDH-E1 ALHDII Aldehyde dehydrogenase family 1 member A1 Aldehyde dehydrogenase, cytosolic | |
| External Links | ||
| UniProt | P00352 | |
| EMBL | M31994 M31982 M31983 M31984 M31985 M31986 M31987 M31988 M31989 M31990 M31991 M31992 AF003341 AY390731 BT006921 AY338497 AL591031 CH471089 BC001505 S61235 M26761 K03000 | |
| CCDS | CCDS6644.1 | |
| PIR | A33371 | |
| RefSeq | NP_000680.2 | |
| UniGene | Hs.76392 | |
| ProteinModelPortal | P00352 | |
| SMR | P00352 | |
| BioGrid | 106718 | |
| IntAct | P00352 | |
| MINT | MINT-4999613 | |
| STRING | 9606.ENSP00000297785 | |
| BindingDB | P00352 | |
| ChEMBL | CHEMBL3577 | |
| DrugBank | DB00755 DB00162 | |
| PhosphoSite | P00352 | |
| DMDM | 118495 | |
| DOSAC-COBS-2DPAGE | P00352 | |
| REPRODUCTION-2DPAGE | IPI00218914 P00352 | |
| SWISS-2DPAGE | P00352 | |
| UCD-2DPAGE | P00352 | |
| MaxQB | P00352 | |
| PaxDb | P00352 | |
| PeptideAtlas | P00352 | |
| PRIDE | P00352 | |
| DNASU | 216 | |
| Ensembl | ENST00000297785 | |
| GeneID | 216 | |
| KEGG | hsa:216 | |
| UCSC | uc004ajd.3 | |
| CTD | 216 | |
| GeneCards | GC09M075515 | |
| HGNC | HGNC:402 | |
| HPA | CAB020690 HPA002123 | |
| MIM | 100640 | |
| neXtProt | NX_P00352 | |
| PharmGKB | PA24692 | |
| eggNOG | COG1012 | |
| HOGENOM | HOG000271505 | |
| HOVERGEN | HBG000097 | |
| InParanoid | P00352 | |
| KO | K07249 | |
| OMA | VEFAHIG | |
| OrthoDB | EOG7PS1F7 | |
| PhylomeDB | P00352 | |
| TreeFam | TF300455 | |
| BioCyc | MetaCyc:HS09183-MONOMER | |
| Reactome | REACT_34 | |
| SABIO-RK | P00352 | |
| UniPathway | UPA00912 | |
| ChiTaRS | ALDH1A1 | |
| GeneWiki | ALDH1A1 | |
| GenomeRNAi | 216 | |
| NextBio | 874 | |
| PRO | PR:P00352 | |
| Proteomes | UP000005640 | |
| Bgee | P00352 | |
| CleanEx | HS_ALDH1A1 | |
| ExpressionAtlas | P00352 | |
| Genevestigator | P00352 | |
| GO | GO:0005737 GO:0005829 GO:0070062 GO:0004029 GO:0005497 GO:0005099 GO:0001758 GO:0006081 GO:0006069 GO:0032320 GO:0042572 GO:0044281 GO:0006805 | |
| Gene3D | 3.40.309.10 3.40.605.10 | |
| InterPro | IPR016161 IPR016163 IPR016160 IPR029510 IPR016162 IPR015590 | |
| Pfam | PF00171 | |
| SUPFAM | SSF53720 | |
| PROSITE | PS00070 PS00687 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000314 |
F |
Table 1, The gels were stained for ALDH activity with an agar overlay containing propionaldehyde or benzaldehyde |
complete | |||||
|
involved_in |
GO:0120163 |
negative regulation of cold-induced thermogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051287 |
NAD binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001758 |
retinal dehydrogenase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001523 |
retinoid metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0018479 |
benzaldehyde dehydrogenase (NAD+) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000192776 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0012036 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016620 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001758 |
retinal dehydrogenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006081 |
cellular aldehyde metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005497 |
androgen binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061624 |
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate |
Reactome:R-HSA-70350 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006069 |
ethanol oxidation |
Reactome:R-HSA-71384 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-71691 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042572 |
retinol metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00912 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Hopkinson, DA et al. () Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH). Alcohol 2 73-8 PubMed GONUTS page
- ↑ Kiefer, FW et al. (2012) Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat. Med. 18 918-25 PubMed GONUTS page
- ↑ Bateman, OA et al. (2003) Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry 42 4349-56 PubMed GONUTS page
- ↑ 4.0 4.1 Morgan, CA & Hurley, TD (2015) Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chem. Biol. Interact. 234 29-37 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 8.0 8.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Pereira, F et al. (1991) The 56 kDa androgen binding protein is an aldehyde dehydrogenase. Biochem. Biophys. Res. Commun. 175 831-8 PubMed GONUTS page
- ↑ Hsu, LC et al. (1985) Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. Proc. Natl. Acad. Sci. U.S.A. 82 3771-5 PubMed GONUTS page
a
f
n
o
r
