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HUMAN:AGRP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AGRP (synonyms: AGRT, ART)
Protein Name(s) Agouti-related protein
External Links
UniProt O00253
EMBL U88063
U89485
AF314194
AF281309
DQ374394
BC110443
CCDS CCDS10839.1
RefSeq NP_001129.1
UniGene Hs.104633
PDB 1HYK
1MR0
2IQV
PDBsum 1HYK
1MR0
2IQV
ProteinModelPortal O00253
SMR O00253
BioGrid 106688
STRING 9606.ENSP00000290953
PaxDb O00253
PRIDE O00253
Ensembl ENST00000290953
GeneID 181
KEGG hsa:181
UCSC uc002etg.1
CTD 181
GeneCards GC16M067516
HGNC HGNC:330
HPA HPA041017
MIM 601665
602311
neXtProt NX_O00253
PharmGKB PA24627
eggNOG NOG44906
GeneTree ENSGT00510000048590
HOGENOM HOG000033861
HOVERGEN HBG050467
InParanoid O00253
KO K05231
OMA MQGAQMG
OrthoDB EOG74TX1T
PhylomeDB O00253
TreeFam TF330729
EvolutionaryTrace O00253
GeneWiki Agouti-related_peptide
GenomeRNAi 181
NextBio 738
PRO PR:O00253
Proteomes UP000005640
Bgee O00253
CleanEx HS_AGRP
ExpressionAtlas O00253
Genevestigator O00253
GO GO:0005615
GO:0070062
GO:0005796
GO:0043025
GO:0005184
GO:0005102
GO:0008343
GO:0042755
GO:0007631
GO:0009755
GO:0060135
GO:0007218
GO:0009648
GO:2000253
GO:0060259
GO:0032868
Gene3D 4.10.760.10
InterPro IPR007733
IPR027300
PANTHER PTHR16551
Pfam PF05039
SMART SM00792
SUPFAM SSF57055
PROSITE PS60024
PS51150

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0060259

regulation of feeding behavior

PMID:9311920[1]

ECO:0000315

P

Based on Figure 4, which shows the difference in weight of mice with the gene and without.

complete
CACAO 2111

involved_in

GO:0060259

regulation of feeding behavior

PMID:9311920[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060259

regulation of feeding behavior

PMID:15927146[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:15927146[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

PMID:15927146[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:15927146[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

PMID:15927146[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:2000253

positive regulation of feeding behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

involved_in

GO:0060135

maternal process involved in female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

involved_in

GO:0048571

long-day photoperiodism

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

C

Seeded From UniProt

complete

involved_in

GO:0042755

eating behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

involved_in

GO:0032868

response to insulin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

involved_in

GO:0008343

adult feeding behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG1
ensembl:ENSRNOP00000056384

C

Seeded From UniProt

complete

involved_in

GO:0008343

adult feeding behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56473
ensembl:ENSMUSP00000142044

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56473
ensembl:ENSMUSP00000142044

P

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56473
ensembl:ENSMUSP00000142044

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027300
InterPro:IPR036836

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007733

C

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007733

P

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

PMID:9751529[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:9311920[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

PMID:9311920[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:10318826[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0133

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Ollmann, MM et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278 135-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 de Rijke, CE et al. (2005) Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness. Biochem. Pharmacol. 70 308-16 PubMed GONUTS page
  3. ↑ Rossi, M et al. (1998) A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139 4428-31 PubMed GONUTS page
  4. ↑ Yang, YK et al. (1999) Contribution of melanocortin receptor exoloops to Agouti-related protein binding. J. Biol. Chem. 274 14100-6 PubMed GONUTS page
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