GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:ADHX

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ADH5 (ECO:0000312 with HGNC:HGNC:253) (synonyms: ADHX, FDH)
Protein Name(s) Alcohol dehydrogenase class-3

Alcohol dehydrogenase 5 Alcohol dehydrogenase class chi chain Alcohol dehydrogenase class-III Glutathione-dependent formaldehyde dehydrogenase FALDH FDH GSH-FDH S-(hydroxymethyl)glutathione dehydrogenase

External Links
UniProt P11766
EMBL M30471
M29872
M81118
M81112
M81113
M81114
M81115
M81116
M81117
CR541689
BT019832
AY987960
BC014665
CCDS CCDS47111.1
PIR JH0789
RefSeq NP_000662.3
UniGene Hs.78989
PDB 1M6H
1M6W
1MA0
1MC5
1MP0
1TEH
2FZE
2FZW
3QJ5
PDBsum 1M6H
1M6W
1MA0
1MC5
1MP0
1TEH
2FZE
2FZW
3QJ5
ProteinModelPortal P11766
SMR P11766
BioGrid 106640
IntAct P11766
MINT MINT-1374117
STRING 9606.ENSP00000296412
ChEMBL CHEMBL2096668
PhosphoSite P11766
DMDM 113408
REPRODUCTION-2DPAGE IPI00746777
MaxQB P11766
PaxDb P11766
PRIDE P11766
DNASU 128
Ensembl ENST00000296412
GeneID 128
KEGG hsa:128
UCSC uc003hui.3
CTD 128
GeneCards GC04M099992
HGNC HGNC:253
HPA HPA044578
MIM 103710
neXtProt NX_P11766
PharmGKB PA24574
eggNOG COG1062
HOGENOM HOG000294674
HOVERGEN HBG000195
InParanoid P11766
KO K00121
OMA WKSVESI
OrthoDB EOG72NRQ6
PhylomeDB P11766
TreeFam TF300429
SABIO-RK P11766
ChiTaRS ADH5
EvolutionaryTrace P11766
GeneWiki ADH5
GenomeRNAi 128
NextBio 511
PRO PR:P11766
Proteomes UP000005640
Bgee P11766
CleanEx HS_ADH5
ExpressionAtlas P11766
Genevestigator P11766
GO GO:0070062
GO:0005739
GO:0005634
GO:0004022
GO:0009055
GO:0005504
GO:0018467
GO:0051903
GO:0008270
GO:0007568
GO:0006068
GO:0006069
GO:0046294
GO:0018119
GO:0045777
GO:0003016
GO:0032496
GO:0051409
GO:0051775
GO:0001523
Gene3D 3.40.50.720
3.90.180.10
InterPro IPR014183
IPR013149
IPR013154
IPR002085
IPR002328
IPR011032
IPR016040
PANTHER PTHR11695
Pfam PF08240
PF00107
SUPFAM SSF50129
TIGRFAMs TIGR02818
PROSITE PS00059

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004022

alcohol dehydrogenase (NAD) activity

PMID:8460164[1]

ECO:0000266

PMID:8460164[1]


F

Table 3 shows a comparison of sequences of ADHs around residue 115 between species.

complete
CACAO 12618

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0051775

response to redox state

PMID:8460164[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0018467

formaldehyde dehydrogenase activity

PMID:8460164[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:6375718[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005504

fatty acid binding

PMID:8460164[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051903

S-(hydroxymethyl)glutathione dehydrogenase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG50010
FB:FBgn0011768
MGI:MGI:87929
PANTHER:PTN000191653
SGD:S000002327

F

Seeded From UniProt

complete

involved_in

GO:0046294

formaldehyde catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG50010
MGI:MGI:87929
PANTHER:PTN000191653
SGD:S000002327

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG50010
PANTHER:PTN000191653
RGD:621638
UniProtKB:P00325
UniProtKB:P08319
UniProtKB:P11766

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG50010
PANTHER:PTN000191653
RGD:2044
TAIR:locus:2009512
TAIR:locus:2025237
UniProtKB:P00325
UniProtKB:P00326
UniProtKB:P07327
UniProtKB:P08319
UniProtKB:P40394

C

Seeded From UniProt

complete

enables

GO:0004024

alcohol dehydrogenase activity, zinc-dependent

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG50010
MGI:MGI:1349472
PANTHER:PTN000191653
UniProtKB:P00325
UniProtKB:P00326
UniProtKB:P07327
UniProtKB:P08319
UniProtKB:P28332
UniProtKB:P40394

F

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0009055

P

Seeded From UniProt

complete

enables

GO:0051903

S-(hydroxymethyl)glutathione dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

F

Seeded From UniProt

complete

involved_in

GO:0051409

response to nitrosative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

P

Seeded From UniProt

complete

involved_in

GO:0046294

formaldehyde catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

P

Seeded From UniProt

complete

involved_in

GO:0045777

positive regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

F

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

P

Seeded From UniProt

complete

involved_in

GO:0018119

peptidyl-cysteine S-nitrosylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

C

Seeded From UniProt

complete

enables

GO:0004022

alcohol dehydrogenase (NAD) activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

F

Seeded From UniProt

complete

involved_in

GO:0003016

respiratory system process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

P

Seeded From UniProt

complete

involved_in

GO:0001523

retinoid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28474
ensembl:ENSMUSP00000005964

P

Seeded From UniProt

complete

involved_in

GO:0006069

ethanol oxidation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014183

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002328
InterPro:IPR014183

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002328

F

Seeded From UniProt

complete

enables

GO:0051903

S-(hydroxymethyl)glutathione dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014183

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002328
InterPro:IPR013149
InterPro:IPR013154
InterPro:IPR014183

P

Seeded From UniProt

complete

enables

GO:0004022

alcohol dehydrogenase (NAD) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.1

F

Seeded From UniProt

complete

enables

GO:0051903

S-(hydroxymethyl)glutathione dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.284

F

Seeded From UniProt

complete

enables

GO:0051903

S-(hydroxymethyl)glutathione dehydrogenase activity

PMID:8460164[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

PMID:8460164[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006069

ethanol oxidation

Reactome:R-HSA-71384

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5692237

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Engeland, K et al. (1993) Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. Proc. Natl. Acad. Sci. U.S.A. 90 2491-4 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ Wagner, FW et al. (1984) Physical and enzymatic properties of a class III isozyme of human liver alcohol dehydrogenase: chi-ADH. Biochemistry 23 2193-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:ADHX&oldid=5954110"