HUMAN:ACVR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ACVR1 (synonyms: ACVRLK2)
Protein Name(s)	Activin receptor type-1 Activin receptor type I ACTR-I Activin receptor-like kinase 2 ALK-2 Serine/threonine-protein kinase receptor R1 SKR1 TGF-B superfamily receptor type I TSR-I
External Links
UniProt	Q04771
EMBL	L02911 Z22534 BC033867
CCDS	CCDS2206.1
PIR	A45992
RefSeq	NP_001096.1 NP_001104537.1 XP_005246996.1 XP_005246997.1 XP_006712888.1
UniGene	Hs.470316
PDB	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
PDBsum	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
ProteinModelPortal	Q04771
SMR	Q04771
BioGrid	106605
DIP	DIP-212N
IntAct	Q04771
MINT	MINT-1340145
STRING	9606.ENSP00000263640
BindingDB	Q04771
ChEMBL	CHEMBL5903
DrugBank	DB00171
GuidetoPHARMACOLOGY	1785
PhosphoSite	Q04771
DMDM	462447
MaxQB	Q04771
PaxDb	Q04771
PRIDE	Q04771
DNASU	90
Ensembl	ENST00000263640 ENST00000409283 ENST00000410057 ENST00000434821
GeneID	90
KEGG	hsa:90
UCSC	uc002tzm.3
CTD	90
GeneCards	GC02M158594
HGNC	HGNC:171
HPA	HPA007505 HPA046514
MIM	102576 135100
neXtProt	NX_Q04771
Orphanet	337
PharmGKB	PA24492
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000230587
HOVERGEN	HBG054502
InParanoid	Q04771
KO	K04675
OMA	VCEGMSC
OrthoDB	EOG7Q8CN3
PhylomeDB	Q04771
TreeFam	TF314724
BRENDA	2.7.10.2
SignaLink	Q04771
ChiTaRS	ACVR1
EvolutionaryTrace	Q04771
GeneWiki	ACVR1
GenomeRNAi	90
NextBio	335
PRO	PR:Q04771
Proteomes	UP000005640
Bgee	Q04771
CleanEx	HS_ACVR1
ExpressionAtlas	Q04771
Genevestigator	Q04771
GO	GO:0048179 GO:0045177 GO:0005887 GO:0048185 GO:0016361 GO:0005524 GO:0046872 GO:0017046 GO:0042803 GO:0004672 GO:0004674 GO:0004702 GO:0046332 GO:0050431 GO:0005025 GO:0004675 GO:0032924 GO:0002526 GO:0003289 GO:0030509 GO:0060923 GO:0071385 GO:0007368 GO:0003143 GO:0061445 GO:0000082 GO:0001702 GO:0007281 GO:0001701 GO:0001707 GO:0003183 GO:0032926 GO:2001237 GO:0009968 GO:0001755 GO:0060389 GO:0001569 GO:0018107 GO:0060037 GO:0030501 GO:2000017 GO:0045669 GO:0010862 GO:0045944 GO:0045893 GO:0006468 GO:0030278 GO:0048641 GO:0051145 GO:0007179 GO:0001655
InterPro	IPR000472 IPR011009 IPR000719 IPR017441 IPR008271 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
PRINTS	PR00653
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P	occurs_in:(UBERON:0036067) has_regulation_target:(UniProtKB:P13297)\|occurs_in(UBERON:0036067) has_regulation_target:(UniProtKB:Q02085)	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P	has_regulation_target:(UniProtKB:Q15796) occurs_in:(UBERON:0003930)	Seeded From UniProt	complete
involved_in	GO:0003289	atrial septum primum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P	occurs_in:(UBERON:0002087)	Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:19736306^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P17813	P	part_of:(GO:0071560)	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18326817^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:P81172)	Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:9884026^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000017	positive regulation of determination of dorsal identity	PMID:19506109^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061445	endocardial cushion cell fate commitment	PMID:19506109^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060923	cardiac muscle cell fate commitment	PMID:19506109^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:19736306^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19506109^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:18436533^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18436533^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:19506109^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18436533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:18436533^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:19736306^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P17813)	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:19506109^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:19506109^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:19736306^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P17813)	Seeded From UniProt	complete
involved_in	GO:0003289	atrial septum primum morphogenesis	PMID:19506109^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	PMID:19506109^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:19506109^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:12065756^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	PMID:9884026^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	PMID:9884026^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12065756^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:12065756^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12065756^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:9884026^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:8242742^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:8242742^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:8242742^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:8242742^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	PMID:16642017^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017046	peptide hormone binding	PMID:12702211^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:8242742^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:8242742^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8242742^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	PMID:8242742^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 RGD:620200 UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 RGD:620200 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN001907233 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:A0A0B4K7J3 UniProtKB:P37023 UniProtKB:Q90ZK6	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
involved_in	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0051145	smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	F		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	F		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	F		Seeded From UniProt	complete
involved_in	GO:0003289	atrial septum primum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0002526	acute inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37172 ensembl:ENSMUSP00000088453	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR003605 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Romero, D et al. (2010) Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Carcinogenesis 31 359-66 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hashimoto, O et al. (1998) The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells. Cell. Signal. 10 743-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Smith, KA et al. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119 3062-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Inman, GJ et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62 65-74 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Attisano, L et al. (1993) Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75 671-80 PubMed GONUTS page
↑ Shore, EM et al. (2006) A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat. Genet. 38 525-7 PubMed GONUTS page
↑ Chen, VT et al. (2003) Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells. Reprod. Biol. Endocrinol. 1 29 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19736306-1] 1.0 ^1.1 ^1.2 ^1.3 Romero, D et al. (2010) Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Carcinogenesis 31 359-66 PubMed GONUTS page

[PMID:18326817-2] 2.0 ^2.1 ^2.2 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page

[PMID:9884026-3] 3.0 ^3.1 ^3.2 ^3.3 Hashimoto, O et al. (1998) The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells. Cell. Signal. 10 743-9 PubMed GONUTS page

[PMID:19506109-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Smith, KA et al. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119 3062-9 PubMed GONUTS page

[PMID:18436533-5] 5.0 ^5.1 ^5.2 ^5.3 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page

[PMID:12065756-6] 6.0 ^6.1 ^6.2 ^6.3 Inman, GJ et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62 65-74 PubMed GONUTS page

[PMID:8242742-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Attisano, L et al. (1993) Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75 671-80 PubMed GONUTS page

[PMID:16642017-8] Shore, EM et al. (2006) A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat. Genet. 38 525-7 PubMed GONUTS page

[PMID:12702211-9] Chen, VT et al. (2003) Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells. Reprod. Biol. Endocrinol. 1 29 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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