HUMAN:ACVL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ACVRL1 (synonyms: ACVRLK1, ALK1)
Protein Name(s)	Serine/threonine-protein kinase receptor R3 SKR3 Activin receptor-like kinase 1 ALK-1 TGF-B superfamily receptor type I TSR-I
External Links
UniProt	P37023
EMBL	Z22533 L17075 U77713 U77707 U77708 U77709 U77710 U77711 U77712 AC025259 CH471111 BC042637
CCDS	CCDS31804.1
PIR	A49431
RefSeq	NP_000011.2 NP_001070869.1 XP_005269292.1
UniGene	Hs.591026
PDB	2LCR 3MY0 4FAO
PDBsum	2LCR 3MY0 4FAO
ProteinModelPortal	P37023
SMR	P37023
BioGrid	106609
DIP	DIP-5938N
IntAct	P37023
STRING	9606.ENSP00000267008
BindingDB	P37023
ChEMBL	CHEMBL5311
DrugBank	DB00171
GuidetoPHARMACOLOGY	1784
PhosphoSite	P37023
DMDM	3915750
PaxDb	P37023
PRIDE	P37023
DNASU	94
Ensembl	ENST00000388922
GeneID	94
KEGG	hsa:94
UCSC	uc001rzj.3
CTD	94
GeneCards	GC12P052300
GeneReviews	ACVRL1
HGNC	HGNC:175
HPA	HPA007041
MIM	600376 601284
neXtProt	NX_P37023
Orphanet	774 275777
PharmGKB	PA24496
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000230587
HOVERGEN	HBG054502
InParanoid	P37023
KO	K13594
PhylomeDB	P37023
TreeFam	TF314724
BRENDA	2.7.10.2
SignaLink	P37023
ChiTaRS	ACVRL1
GeneWiki	ACVRL1
GenomeRNAi	94
NextBio	355
PRO	PR:P37023
Proteomes	UP000005640
Bgee	P37023
CleanEx	HS_ACVRL1
ExpressionAtlas	P37023
Genevestigator	P37023
GO	GO:0009986 GO:0030425 GO:0005887 GO:0043025 GO:0048185 GO:0016361 GO:0005524 GO:0046872 GO:0019901 GO:0004674 GO:0004702 GO:0046332 GO:0050431 GO:0005025 GO:0005024 GO:0004675 GO:0032924 GO:0001525 GO:0060840 GO:0008015 GO:0002043 GO:0001955 GO:0001974 GO:0030509 GO:0071773 GO:0071560 GO:0061154 GO:0001701 GO:0001946 GO:0060836 GO:0043537 GO:0007162 GO:0030308 GO:0030336 GO:0008285 GO:2000279 GO:0045602 GO:0010596 GO:0001937 GO:0051895 GO:0045766 GO:0030513 GO:0032332 GO:0045603 GO:0001938 GO:0010862 GO:0045944 GO:0045893 GO:0051291 GO:0006468 GO:0008217 GO:0043535 GO:0006275 GO:0001936 GO:0006355 GO:0061298 GO:0007165 GO:0007179 GO:0060841 GO:0035313
InterPro	IPR000472 IPR011009 IPR000719 IPR017441 IPR008271 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
PRINTS	PR00653
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
NOT\|involved_in	GO:0090500	endocardial cushion to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P	has_regulation_target:(UniProtKB:P52799) occurs_in:(UBERON:0004537)	Seeded From UniProt	complete
involved_in	GO:0035912	dorsal aorta morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P	has_regulation_target:(UniProtKB:P28906) occurs_in:(UBERON:0006296)	Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:26176610^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:26176610^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	PMID:19366699^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:19366699^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:19903896^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002138)\|occurs_in:(CL:0002138)	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:19494318^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000138)	Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	PMID:19592636^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060840	artery development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	PMID:19903896^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19366699^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P41134)\|has_regulation_target:(UniProtKB:Q02363)\|has_regulation_target:(UniProtKB:Q13873)\|has_regulation_target:(UniProtKB:P17813)\|has_regulation_target:(UniProtKB:P36897)	Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:19592636^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:17068149^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19366699^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:17068149^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19592636^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P67870	F	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:19366699^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15797) has_regulation_target:(UniProtKB:Q99717)\|has_regulation_target:(UniProtKB:Q15796)	Seeded From UniProt	complete
involved_in	GO:0010596	negative regulation of endothelial cell migration	PMID:17068149^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61288	P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	PMID:12453878^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12393874^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035313	wound healing, spreading of epidermal cells	PMID:12453878^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:12453878^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12453878^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:14684682^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008015	blood circulation	PMID:16752392^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:15702480^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:15702480^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	PMID:12453878^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15702480^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12065756^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12393874^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:16752392^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:8242742^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07200	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:8242742^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8242742^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:8242742^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	PMID:8242742^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 RGD:620200 UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 RGD:620200 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:A0A0B4K7J3 UniProtKB:P37023 UniProtKB:Q90ZK6	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	PMID:8242742^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:8242742^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:8242742^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016361	P		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016361	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0060840	artery development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0045603	positive regulation of endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0045602	negative regulation of endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0035912	dorsal aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61288 ensembl:ENSMUSP00000000542	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR003605 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	C		Seeded From UniProt	complete
involved_in	GO:0043535	regulation of blood vessel endothelial cell migration	PMID:20406889^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006275	regulation of DNA replication	PMID:20406889^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:20406889^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	PMID:20406889^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001936	regulation of endothelial cell proliferation	PMID:20406889^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	PMID:19494318^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8858369	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Alaa El Din, F et al. (2015) Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia. PLoS ONE 10 e0132111 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Upton, PD et al. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284 15794-804 PubMed GONUTS page
↑ ^3.0 ^3.1 Niessen, K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115 1654-61 PubMed GONUTS page
↑ ^4.0 ^4.1 Blaney Davidson, EN et al. (2009) Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J. Immunol. 182 7937-45 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Lee, NY et al. (2009) Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling. FASEB J. 23 3712-21 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 David, L et al. (2007) Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 109 1953-61 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lamouille, S et al. (2002) Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood 100 4495-501 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Inman, GJ et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62 65-74 PubMed GONUTS page
↑ ^9.0 ^9.1 Mo, J et al. (2002) Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. J. Biol. Chem. 277 50788-94 PubMed GONUTS page
↑ Harrison, RE et al. (2003) Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. J. Med. Genet. 40 865-71 PubMed GONUTS page
↑ ^11.0 ^11.1 Bossler, AD et al. (2006) Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Hum. Mutat. 27 667-75 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Blanco, FJ et al. (2005) Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J. Cell. Physiol. 204 574-84 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Attisano, L et al. (1993) Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75 671-80 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page

[PMID:26176610-1] 1.0 ^1.1 Alaa El Din, F et al. (2015) Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia. PLoS ONE 10 e0132111 PubMed GONUTS page

[PMID:19366699-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Upton, PD et al. (2009) Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284 15794-804 PubMed GONUTS page

[PMID:19903896-3] 3.0 ^3.1 Niessen, K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115 1654-61 PubMed GONUTS page

[PMID:19494318-4] 4.0 ^4.1 Blaney Davidson, EN et al. (2009) Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J. Immunol. 182 7937-45 PubMed GONUTS page

[PMID:19592636-5] 5.0 ^5.1 ^5.2 Lee, NY et al. (2009) Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling. FASEB J. 23 3712-21 PubMed GONUTS page

[PMID:17068149-6] 6.0 ^6.1 ^6.2 David, L et al. (2007) Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 109 1953-61 PubMed GONUTS page

[PMID:12453878-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lamouille, S et al. (2002) Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood 100 4495-501 PubMed GONUTS page

[PMID:12065756-8] 8.0 ^8.1 ^8.2 ^8.3 Inman, GJ et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62 65-74 PubMed GONUTS page

[PMID:12393874-9] 9.0 ^9.1 Mo, J et al. (2002) Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. J. Biol. Chem. 277 50788-94 PubMed GONUTS page

[PMID:14684682-10] Harrison, RE et al. (2003) Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. J. Med. Genet. 40 865-71 PubMed GONUTS page

[PMID:16752392-11] 11.0 ^11.1 Bossler, AD et al. (2006) Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Hum. Mutat. 27 667-75 PubMed GONUTS page

[PMID:15702480-12] 12.0 ^12.1 ^12.2 Blanco, FJ et al. (2005) Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J. Cell. Physiol. 204 574-84 PubMed GONUTS page

[PMID:8242742-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Attisano, L et al. (1993) Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75 671-80 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20406889-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page

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