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HUMAN:ACSF3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ACSF3 | |
| Protein Name(s) | Acyl-CoA synthetase family member 3, mitochondrial | |
| External Links | ||
| UniProt | Q4G176 | |
| EMBL | AK075499 AK290963 AC009113 AC135782 CH471184 BC028399 BC072391 | |
| CCDS | CCDS10974.1 | |
| RefSeq | NP_001120686.1 NP_001230208.1 NP_777577.2 | |
| UniGene | Hs.461727 Hs.720526 | |
| ProteinModelPortal | Q4G176 | |
| SMR | Q4G176 | |
| BioGrid | 128248 | |
| STRING | 9606.ENSP00000320646 | |
| PhosphoSite | Q4G176 | |
| DMDM | 296439438 | |
| MaxQB | Q4G176 | |
| PaxDb | Q4G176 | |
| PRIDE | Q4G176 | |
| Ensembl | ENST00000317447 ENST00000406948 ENST00000614302 | |
| GeneID | 197322 | |
| KEGG | hsa:197322 | |
| UCSC | uc002fmp.3 | |
| CTD | 197322 | |
| GeneCards | GC16P089160 | |
| H-InvDB | HIX0013347 | |
| HGNC | HGNC:27288 | |
| HPA | HPA008322 HPA008323 | |
| MIM | 614245 614265 | |
| neXtProt | NX_Q4G176 | |
| Orphanet | 289504 | |
| PharmGKB | PA162375375 | |
| eggNOG | COG0318 | |
| GeneTree | ENSGT00760000119304 | |
| HOGENOM | HOG000229983 | |
| HOVERGEN | HBG100430 | |
| InParanoid | Q4G176 | |
| KO | K18660 | |
| OMA | WAWSKDD | |
| OrthoDB | EOG7W9RVK | |
| PhylomeDB | Q4G176 | |
| TreeFam | TF312995 | |
| GeneWiki | ACSF3 | |
| GenomeRNAi | 197322 | |
| NextBio | 89644 | |
| PRO | PR:Q4G176 | |
| Proteomes | UP000005640 | |
| Bgee | Q4G176 | |
| CleanEx | HS_ACSF3 | |
| ExpressionAtlas | Q4G176 | |
| Genevestigator | Q4G176 | |
| GO | GO:0005739 GO:0016878 GO:0005524 GO:0090409 GO:0006633 GO:0006631 GO:0090410 | |
| InterPro | IPR025110 IPR020845 IPR000873 | |
| Pfam | PF00501 PF13193 | |
| PROSITE | PS00455 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005836 |
fatty-acyl-CoA synthase complex |
ECO:0000314 |
C |
Table 4 |
complete | |||||
| GO:0090409 |
malonyl-CoA synthetase activity |
ECO:0000314 |
F |
Fig. 1D shows the enzyme converting malonate to malonyl-CoA in the presence of ATP and CoA. |
complete | |||||
|
involved_in |
GO:0090410 |
malonate catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090410 |
malonate catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090409 |
malonyl-CoA synthetase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:17453)|has_direct_input:(CHEBI:15792) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0090409 |
malonyl-CoA synthetase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016878 |
acid-thiol ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031957 |
very long-chain fatty acid-CoA ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035338 |
long-chain fatty-acyl-CoA biosynthetic process |
Reactome:R-HSA-75876 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031957 |
very long-chain fatty acid-CoA ligase activity |
Reactome:R-HSA-5696007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-5696007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Watkins, PA et al. (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J. Lipid Res. 48 2736-50 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Witkowski, A et al. (2011) Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. J. Biol. Chem. 286 33729-36 PubMed GONUTS page
- ↑ 3.0 3.1 Chen, H et al. (2011) Malonyl-CoA synthetase, encoded by ACYL ACTIVATING ENZYME13, is essential for growth and development of Arabidopsis. Plant Cell 23 2247-62 PubMed GONUTS page
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