HUMAN:ABCA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ABCA1 (synonyms: ABC1, CERP)
Protein Name(s)	ATP-binding cassette sub-family A member 1 ATP-binding cassette transporter 1 ABC-1 ATP-binding cassette 1 Cholesterol efflux regulatory protein
External Links
UniProt	O95477
EMBL	AF275948 AL353685 AL359846 AL359846 AL353685 AF285167 AF287262 AB055982 AJ012376 AF165281 AF165286 AF165282 AF165283 AF165284 AF165285 AF165306 AF165287 AF165288 AF165289 AF165290 AF165291 AF165292 AF165293 AF165294 AF165295 AF165296 AF165297 AF165298 AF165299 AF165300 AF165301 AF165302 AF165303 AF165304 AF165305 AF165309 AF165307 AF165308 AF165310
CCDS	CCDS6762.1
RefSeq	NP_005493.2
UniGene	Hs.659274
ProteinModelPortal	O95477
BioGrid	106537
DIP	DIP-29211N
IntAct	O95477
MINT	MINT-239561
STRING	9606.ENSP00000363868
ChEMBL	CHEMBL2362986
DrugBank	DB00171 DB01016 DB01599
GuidetoPHARMACOLOGY	756
TCDB	3.A.1.211.14
PhosphoSite	O95477
BioMuta	ABCA1
MaxQB	O95477
PaxDb	O95477
PRIDE	O95477
Ensembl	ENST00000374736
GeneID	19
KEGG	hsa:19
UCSC	uc004bcl.3
CTD	19
GeneCards	GC09M107543
HGNC	HGNC:29
HPA	CAB069889 HPA057283
MIM	205400 600046 604091
neXtProt	NX_O95477
Orphanet	425 31150
PharmGKB	PA24373
eggNOG	COG1131
GeneTree	ENSGT00760000118965
HOVERGEN	HBG050436
InParanoid	O95477
KO	K05641
OMA	DTTVTRG
OrthoDB	EOG78D7J6
PhylomeDB	O95477
TreeFam	TF105191
Reactome	REACT_116145 REACT_13621
SignaLink	O95477
ChiTaRS	ABCA1
GeneWiki	ABCA1
GenomeRNAi	19
NextBio	51
PRO	PR:O95477
Proteomes	UP000005640
Bgee	O95477
ExpressionAtlas	O95477
Genevisible	O95477
GO	GO:0030139 GO:0009897 GO:0005794 GO:0005887 GO:0045121 GO:0048471 GO:0045335 GO:0005886 GO:0008509 GO:0034186 GO:0034188 GO:0034185 GO:0005524 GO:0042626 GO:0051117 GO:0015485 GO:0017127 GO:0005543 GO:0005548 GO:0005102 GO:0031267 GO:0019905 GO:0038027 GO:0044255 GO:0071222 GO:0071300 GO:0033344 GO:0042632 GO:0008203 GO:0016197 GO:0007186 GO:0034380 GO:0050702 GO:0032367 GO:0042157 GO:0007040 GO:0010887 GO:0010745 GO:0002790 GO:0006911 GO:0033700 GO:0055091 GO:0045332 GO:0060155 GO:0030819 GO:0010875 GO:0006497 GO:0032489 GO:0034616 GO:0055098 GO:0043691 GO:0044281 GO:0055085
Gene3D	3.40.50.300
InterPro	IPR003593 IPR026082 IPR003439 IPR017871 IPR030365 IPR027417
PANTHER	PTHR19229 PTHR19229:SF34
Pfam	PF00005
SMART	SM00382
SUPFAM	SSF52540
PROSITE	PS00211 PS50893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:14754908^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:25084135^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000517)	Seeded From UniProt	complete
enables	GO:0090556	phosphatidylserine-translocating ATPase activity	PMID:24097981^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0045332)	Seeded From UniProt	complete
involved_in	GO:0045332	phospholipid translocation	PMID:24097981^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	transports_or_maintains_localization_of:(CHEBI:64482)\|transports_or_maintains_localization_of:(CHEBI:18303)	Seeded From UniProt	complete
enables	GO:0090554	phosphatidylcholine-translocating ATPase activity	PMID:24097981^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	inhibited_by:(CHEBI:16113)\|part_of(GO:0045332)	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:24097981^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:60568)\|activated_by:(CHEBI:74669)\|activated_by:(CHEBI:64583)\|inhibited_by(CHEBI:74986)\|inhibited_by(CHEBI:28874)\|inhibited_by(CHEBI:16113)\|inhibited_by(CHEBI:17761)	Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:23931754^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86UK0	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:23931754^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:23931754^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P41233)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23931754^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:23931754^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55055	F		Seeded From UniProt	complete
involved_in	GO:0060155	platelet dense granule organization	PMID:15163665^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	PMID:15358760^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055091	phospholipid homeostasis	PMID:16702602^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:11855831^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	PMID:15469992^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:15469992^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:10431236^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:10431236^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034616	response to laminar fluid shear stress	PMID:15358760^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:17305370^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:10431236^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034188	apolipoprotein A-I receptor activity	PMID:16443932^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034186	apolipoprotein A-I binding	PMID:11162594^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0034186	apolipoprotein A-I binding	PMID:16443932^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:11162594^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02652	F		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:16702602^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:11162594^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:10431236^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:16443932^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:11162594^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:10431236^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	PMID:16443932^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032367	intracellular cholesterol transport	PMID:10431236^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	PMID:16443932^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60953	F		Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:14701824^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:14747463^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:15469992^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86Y82	F		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	PMID:12084722^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016197	endosomal transport	PMID:14747463^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:12084722^[16]	ECO:0000305	curator inference used in manual assertion	GO:0017127	F		Seeded From UniProt	complete
enables	GO:0008509	anion transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41233	F		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:14747463^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:16443932^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007040	lysosome organization	PMID:15163665^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10525055^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005548	phospholipid transporter activity	PMID:16702602^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:16702602^[7]	ECO:0000305	curator inference used in manual assertion	GO:0005548	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:11700048^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0090556	phosphatidylserine-translocating ATPase activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002710165 UniProtKB:O95477	F		Seeded From UniProt	complete
enables	GO:0090554	phosphatidylcholine-translocating ATPase activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002710165 UniProtKB:O95477	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99607 PANTHER:PTN000442469	C		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000442469 RGD:631344 UniProtKB:O94911	F		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99607 PANTHER:PTN002710165 UniProtKB:O95477	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99607 PANTHER:PTN002710165 UniProtKB:O95477	F		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000442469 UniProtKB:Q86UK0	P		Seeded From UniProt	complete
enables	GO:0005319	lipid transporter activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109424 MGI:MGI:1351646 MGI:MGI:99607 PANTHER:PTN000442469 UniProtKB:O95477 UniProtKB:P78363 UniProtKB:Q86UK0 UniProtKB:Q8IZY2	F		Seeded From UniProt	complete
involved_in	GO:0038027	apolipoprotein A-I-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0034188	P		Seeded From UniProt	complete
involved_in	GO:0098656	anion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008509	P		Seeded From UniProt	complete
involved_in	GO:0098656	anion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008509	P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	P		Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	P		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	P		Seeded From UniProt	complete
involved_in	GO:0015914	phospholipid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	C		Seeded From UniProt	complete
enables	GO:0008035	high-density lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	F		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LNL3 ensembl:ENSRNOP00000024564	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0045332	phospholipid translocation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	C		Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	F		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	C		Seeded From UniProt	complete
enables	GO:0008509	anion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	F		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0006911	phagocytosis, engulfment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
involved_in	GO:0006497	protein lipidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	C		Seeded From UniProt	complete
enables	GO:0005548	phospholipid transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	F		Seeded From UniProt	complete
involved_in	GO:0002790	peptide secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41233 ensembl:ENSMUSP00000030010	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026082	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026082	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026082	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:24097981^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090107	regulation of high-density lipoprotein particle assembly	PMID:24097981^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:18490524^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:18490524^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	Reactome:R-HSA-8963896	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5682103 Reactome:R-HSA-5682101 Reactome:R-HSA-216757 Reactome:R-HSA-216727 Reactome:R-HSA-216723 Reactome:R-HSA-1989765	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-5682103 Reactome:R-HSA-5682084	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Krimbou, L et al. (2004) Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J. Lipid Res. 45 839-48 PubMed GONUTS page
↑ Lv, YC et al. (2014) MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis 236 215-26 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Quazi, F & Molday, RS (2013) Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants. J. Biol. Chem. 288 34414-26 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Fu, Y et al. (2013) ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 18 225-38 PubMed GONUTS page
↑ ^5.0 ^5.1 Nofer, JR et al. (2004) Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). J. Biol. Chem. 279 34032-7 PubMed GONUTS page
↑ ^6.0 ^6.1 Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Kobayashi, A et al. (2006) Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. J. Lipid Res. 47 1791-802 PubMed GONUTS page
↑ Zhou, X et al. (2002) The ATP binding cassette transporter A1 contributes to the secretion of interleukin 1beta from macrophages but not from monocytes. Biochem. Biophys. Res. Commun. 291 598-604 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bared, SM et al. (2004) Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Mol. Biol. Cell 15 5399-407 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Brooks-Wilson, A et al. (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat. Genet. 22 336-45 PubMed GONUTS page
↑ Vedhachalam, C et al. (2007) The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry 46 2583-93 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page
↑ Haidar, B et al. (2004) Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. J. Biol. Chem. 279 9963-9 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Neufeld, EB et al. (2004) The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J. Biol. Chem. 279 15571-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Fitzgerald, ML et al. (2002) Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J. Biol. Chem. 277 33178-87 PubMed GONUTS page
↑ Lawn, RM et al. (1999) The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J. Clin. Invest. 104 R25-31 PubMed GONUTS page
↑ Szakács, G et al. (2001) Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter. Biochem. Biophys. Res. Commun. 288 1258-64 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 Mauldin, JP et al. (2008) Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus. Circulation 117 2785-92 PubMed GONUTS page

[PMID:14754908-1] Krimbou, L et al. (2004) Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J. Lipid Res. 45 839-48 PubMed GONUTS page

[PMID:25084135-2] Lv, YC et al. (2014) MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis 236 215-26 PubMed GONUTS page

[PMID:24097981-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Quazi, F & Molday, RS (2013) Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants. J. Biol. Chem. 288 34414-26 PubMed GONUTS page

[PMID:23931754-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Fu, Y et al. (2013) ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 18 225-38 PubMed GONUTS page

[PMID:15163665-5] 5.0 ^5.1 Nofer, JR et al. (2004) Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). J. Biol. Chem. 279 34032-7 PubMed GONUTS page

[PMID:15358760-6] 6.0 ^6.1 Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page

[PMID:16702602-7] 7.0 ^7.1 ^7.2 ^7.3 Kobayashi, A et al. (2006) Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. J. Lipid Res. 47 1791-802 PubMed GONUTS page

[PMID:11855831-8] Zhou, X et al. (2002) The ATP binding cassette transporter A1 contributes to the secretion of interleukin 1beta from macrophages but not from monocytes. Biochem. Biophys. Res. Commun. 291 598-604 PubMed GONUTS page

[PMID:15469992-9] 9.0 ^9.1 ^9.2 Bared, SM et al. (2004) Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Mol. Biol. Cell 15 5399-407 PubMed GONUTS page

[PMID:10431236-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Brooks-Wilson, A et al. (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat. Genet. 22 336-45 PubMed GONUTS page

[PMID:17305370-11] Vedhachalam, C et al. (2007) The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry 46 2583-93 PubMed GONUTS page

[PMID:16443932-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page

[PMID:11162594-13] 13.0 ^13.1 ^13.2 ^13.3 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page

[PMID:14701824-14] Haidar, B et al. (2004) Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. J. Biol. Chem. 279 9963-9 PubMed GONUTS page

[PMID:14747463-15] 15.0 ^15.1 ^15.2 Neufeld, EB et al. (2004) The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J. Biol. Chem. 279 15571-8 PubMed GONUTS page

[PMID:12084722-16] 16.0 ^16.1 Fitzgerald, ML et al. (2002) Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J. Biol. Chem. 277 33178-87 PubMed GONUTS page

[PMID:10525055-17] Lawn, RM et al. (1999) The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J. Clin. Invest. 104 R25-31 PubMed GONUTS page

[PMID:11700048-18] Szakács, G et al. (2001) Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter. Biochem. Biophys. Res. Commun. 288 1258-64 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18490524-20] 20.0 ^20.1 Mauldin, JP et al. (2008) Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus. Circulation 117 2785-92 PubMed GONUTS page

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