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HUMAN:A4D1A2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CHN2
Protein Name(s) Chimerin (Chimaerin) 2

cDNA, FLJ93489, Homo sapiens chimerin (chimaerin) 2 (CHN2), mRNA

External Links
UniProt A4D1A2
EMBL AK313021
CH236948
CH471073
RefSeq NP_004058.1
UniGene Hs.654611
Hs.654753
Hs.663145
Hs.710429
SMR A4D1A2
GeneID 1124
KEGG hsa:1124
CTD 1124
PharmGKB PA26474
HOVERGEN HBG080489
GenomeRNAi 1124
NextBio 4668
ArrayExpress A4D1A2
GO GO:0005622
GO:0046872
GO:0035556
Gene3D 1.10.555.10
3.30.505.10
InterPro IPR020454
IPR017356
IPR002219
IPR008936
IPR000198
IPR000980
Pfam PF00130
PF00620
PF00017
PIRSF PIRSF038015
PRINTS PR00008
SMART SM00109
SM00324
SM00252
SUPFAM SSF48350
PROSITE PS50238
PS50001
PS00479
PS50081

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0009967

positive regulation of signal transduction

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005070

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017356
InterPro:IPR037860

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000198
InterPro:IPR008936

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002219

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037860

P

Seeded From UniProt

complete

involved_in

GO:0051056

regulation of small GTPase mediated signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017356

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:7614486[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

PMID:8175705[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051056

regulation of small GTPase mediated signal transduction

Reactome:R-HSA-194840

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-194922

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0343

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yuan, S et al. (1995) Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma. Cancer Res. 55 3456-61 PubMed GONUTS page
  2. Leung, T et al. (1994) Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. J. Biol. Chem. 269 12888-92 PubMed GONUTS page