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HUMAN:6PGL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PGLS
Protein Name(s) 6-phosphogluconolactonase

6PGL

External Links
UniProt O95336
EMBL AJ243972
BC014006
AF091091
CCDS CCDS12361.1
RefSeq NP_036220.1
UniGene Hs.466165
ProteinModelPortal O95336
SMR O95336
BioGrid 117328
MINT MINT-5000838
STRING 9606.ENSP00000252603
PhosphoSite O95336
OGP O95336
REPRODUCTION-2DPAGE IPI00029997
MaxQB O95336
PaxDb O95336
PeptideAtlas O95336
PRIDE O95336
DNASU 25796
Ensembl ENST00000252603
GeneID 25796
KEGG hsa:25796
UCSC uc002ngw.3
CTD 25796
GeneCards GC19P017622
HGNC HGNC:8903
HPA HPA040744
HPA042032
MIM 604951
neXtProt NX_O95336
PharmGKB PA33240
eggNOG COG0363
GeneTree ENSGT00550000075110
HOGENOM HOG000256285
HOVERGEN HBG000030
InParanoid O95336
KO K01057
OMA PQGELWW
OrthoDB EOG7RZ5QV
PhylomeDB O95336
TreeFam TF318609
BioCyc MetaCyc:HS05370-MONOMER
BRENDA 3.1.1.31
Reactome REACT_1859
UniPathway UPA00115
GenomeRNAi 25796
NextBio 46981
PRO PR:O95336
Proteomes UP000005640
Bgee O95336
CleanEx HS_PGLS
ExpressionAtlas O95336
Genevestigator O95336
GO GO:0005829
GO:0070062
GO:0017057
GO:0048029
GO:0005975
GO:0006098
GO:0009051
GO:0044281
InterPro IPR005900
IPR006148
Pfam PF01182
TIGRFAMs TIGR01198

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

enables

GO:0017057

6-phosphogluconolactonase activity

PMID:10518023[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006098

pentose-phosphate shunt

PMID:10518023[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017057

6-phosphogluconolactonase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000114544
RGD:1307001
SGD:S000000718
SGD:S000001206
SGD:S000003480
SGD:S000005317
TAIR:locus:2152906
UniProtKB:O95336

F

Seeded From UniProt

complete

involved_in

GO:0009051

pentose-phosphate shunt, oxidative branch

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000114544
RGD:1307001

P

Seeded From UniProt

complete

enables

GO:0017057

6-phosphogluconolactonase activity

PMID:10518023[3]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005900
InterPro:IPR006148

P

Seeded From UniProt

complete

involved_in

GO:0006098

pentose-phosphate shunt

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005900

P

Seeded From UniProt

complete

enables

GO:0017057

6-phosphogluconolactonase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005900

F

Seeded From UniProt

complete

enables

GO:0017057

6-phosphogluconolactonase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.31

F

Seeded From UniProt

complete

involved_in

GO:0006098

pentose-phosphate shunt

Reactome:R-HSA-71336

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-71296

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006098

pentose-phosphate shunt

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00115

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. 3.0 3.1 3.2 Collard, F et al. (1999) Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1). FEBS Lett. 459 223-6 PubMed GONUTS page
  4. 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page