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HUMAN:5NTC

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NT5C2 (synonyms: NT5B, NT5CP, PNT5)
Protein Name(s) Cytosolic purine 5'-nucleotidase

Cytosolic 5'-nucleotidase II

External Links
UniProt P49902
EMBL D38524
AK295593
AL139817
AL360001
AL360001
AL139817
CH471066
CH471066
BC001595
CCDS CCDS7544.1
PIR JC2436
RefSeq NP_001127845.1
NP_036361.1
XP_005269693.1
XP_005269696.1
UniGene Hs.97439
PDB 2J2C
2JC9
2JCM
2XCV
2XCW
2XCX
2XJB
2XJC
2XJD
2XJE
2XJF
4H4B
5CQZ
5CR7
5K7Y
5L4Z
5L50
PDBsum 2J2C
2JC9
2JCM
2XCV
2XCW
2XCX
2XJB
2XJC
2XJD
2XJE
2XJF
4H4B
5CQZ
5CR7
5K7Y
5L4Z
5L50
ProteinModelPortal P49902
SMR P49902
BioGrid 116627
IntAct P49902
MINT MINT-1436872
STRING 9606.ENSP00000339479
DrugBank DB00171
DB00811
DEPOD P49902
iPTMnet P49902
PhosphoSitePlus P49902
BioMuta NT5C2
DMDM 1703012
EPD P49902
MaxQB P49902
PaxDb P49902
PeptideAtlas P49902
PRIDE P49902
TopDownProteomics P49902-1
DNASU 22978
Ensembl ENST00000343289
ENST00000404739
GeneID 22978
KEGG hsa:22978
UCSC uc001kwq.4
CTD 22978
DisGeNET 22978
GeneCards NT5C2
HGNC HGNC:8022
HPA HPA003751
MalaCards NT5C2
MIM 600417
613162
neXtProt NX_P49902
OpenTargets ENSG00000076685
Orphanet 320396
PharmGKB PA31801
eggNOG KOG2469
ENOG410XQAV
GeneTree ENSGT00550000074539
HOGENOM HOG000246075
HOVERGEN HBG000025
KO K01081
OMA VMLGEMY
OrthoDB EOG091G074N
PhylomeDB P49902
TreeFam TF315266
BioCyc MetaCyc:HS01216-MONOMER
BRENDA 3.1.3.5
Reactome [www.reactome.org/content/detail/R-HSA-2161541 R-HSA-2161541]
[www.reactome.org/content/detail/R-HSA-74259 R-HSA-74259]
SABIO-RK P49902
ChiTaRS NT5C2
EvolutionaryTrace P49902
GenomeRNAi 22978
PRO PR:P49902
Proteomes UP000005640
Bgee ENSG00000076685
CleanEx HS_NT5C2
ExpressionAtlas P49902
Genevisible P49902
GO GO:0005829
GO:0008253
GO:0046872
GO:0050146
GO:0000166
GO:0046085
GO:0017144
GO:0046040
GO:0006195
Gene3D 3.40.50.1000
InterPro IPR023214
IPR008380
IPR016695
PANTHER PTHR12103
Pfam PF05761
PIRSF PIRSF017434
SUPFAM SSF56784
TIGRFAMs TIGR02244

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0046085

adenosine metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250755
RGD:2323387

P

Seeded From UniProt

complete

involved_in

GO:0046040

IMP metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250755
RGD:2323387

P

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250728
RGD:2323387
UniProtKB:P49902

F

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0046085

adenosine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZMY7
ensembl:ENSRNOP00000027351

P

Seeded From UniProt

complete

involved_in

GO:0046040

IMP metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZMY7
ensembl:ENSRNOP00000027351

P

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZMY7
ensembl:ENSRNOP00000027351

F

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.5

F

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

PMID:7999131[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0017144

drug metabolic process

Reactome:R-HSA-2161541

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006195

purine nucleotide catabolic process

Reactome:R-HSA-74259

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-74248
Reactome:R-HSA-2162066

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

GO:0006195

purine nucleotide catabolic process

PMID:28327087[3]

ECO:0000315

P

Maintains homeostasis of purine/pyrimidine nucleotides located intracellularly.

complete
CACAO 12765

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0009117

nucleotide metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0546

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Oka, J et al. (1994) Molecular cloning of human cytosolic purine 5'-nucleotidase. Biochem. Biophys. Res. Commun. 205 917-22 PubMed GONUTS page
  3. ↑ Elsaid, MF et al. (2017) NT5C2 novel splicing variant expands the phenotypic spectrum of Spastic Paraplegia (SPG45): case report of a new member of thin corpus callosum SPG-Subgroup. BMC Med. Genet. 18 33 PubMed GONUTS page
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