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HUMAN:2ABA

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PPP2R2A
Protein Name(s) Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

PP2A subunit B isoform B55-alpha PP2A subunit B isoform PR55-alpha PP2A subunit B isoform R2-alpha PP2A subunit B isoform alpha

External Links
UniProt P63151
EMBL M64929
AK303981
AK314823
AC022911
CH471080
BC041071
CCDS CCDS34867.1
CCDS55213.1
PIR A38351
RefSeq NP_001171062.1
NP_002708.1
UniGene Hs.146339
PDB 3DW8
PDBsum 3DW8
ProteinModelPortal P63151
SMR P63151
BioGrid 111512
DIP DIP-29398N
IntAct P63151
MINT MINT-2835351
STRING 9606.ENSP00000370113
BindingDB P63151
ChEMBL CHEMBL4284
PhosphoSite P63151
DMDM 52783535
MaxQB P63151
PaxDb P63151
PeptideAtlas P63151
PRIDE P63151
DNASU 5520
Ensembl ENST00000315985
ENST00000380737
GeneID 5520
KEGG hsa:5520
UCSC uc003xeu.3
uc011laf.2
CTD 5520
GeneCards GC08P026204
HGNC HGNC:9304
HPA HPA042122
HPA042770
MIM 604941
neXtProt NX_P63151
PharmGKB PA33668
eggNOG COG5170
GeneTree ENSGT00390000006311
HOGENOM HOG000089745
HOVERGEN HBG000012
InParanoid P63151
KO K04354
OMA FLKFSLR
OrthoDB EOG7Q5HCZ
PhylomeDB P63151
TreeFam TF105553
Reactome REACT_160242
REACT_1857
REACT_75822
REACT_821
SignaLink P63151
ChiTaRS PPP2R2A
EvolutionaryTrace P63151
GeneWiki PPP2R2A
GenomeRNAi 5520
NextBio 21352
PRO PR:P63151
Proteomes UP000005640
Bgee P63151
CleanEx HS_PPP2R2A
ExpressionAtlas P63151
Genevestigator P63151
GO GO:0005829
GO:0005654
GO:0000159
GO:0008601
GO:0004722
GO:0000086
GO:0010467
GO:0000278
GO:0007084
GO:0016071
GO:0000184
GO:0006470
GO:0050790
GO:0043278
GO:0016070
GO:0007165
Gene3D 2.130.10.10
InterPro IPR000009
IPR018067
IPR015943
IPR001680
IPR017986
PANTHER PTHR11871
PIRSF PIRSF037309
PRINTS PR00600
SMART SM00320
SUPFAM SSF50978
PROSITE PS01024
PS01025

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006470

protein dephosphorylation

PMID:1849734[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004722

protein serine/threonine phosphatase activity

PMID:1849734[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

PMID:17245430[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

PMID:1849734[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070262

peptidyl-serine dephosphorylation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000221745
SGD:S000003158

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000221745
RGD:631441
TAIR:locus:2007963
dictyBase:DDB_G0283905

C

Seeded From UniProt

complete

contributes_to

GO:0004722

protein serine/threonine phosphatase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000221745
UniProtKB:P63151
dictyBase:DDB_G0283905

F

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004889
PANTHER:PTN000221745

P

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000221745
PomBase:SPAC227.07c
RGD:631441
SGD:S000003158
UniProtKB:P63151
dictyBase:DDB_G0283905

C

Seeded From UniProt

complete

involved_in

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0019888

P

Seeded From UniProt

complete

involved_in

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019888

P

Seeded From UniProt

complete

enables

GO:0051721

protein phosphatase 2A binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P36876
ensembl:ENSRNOP00000015318

F

Seeded From UniProt

complete

enables

GO:0048156

tau protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P36876
ensembl:ENSRNOP00000015318

F

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P36876
ensembl:ENSRNOP00000015318

F

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6P1F6
ensembl:ENSMUSP00000086640

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6P1F6
ensembl:ENSMUSP00000086640

C

Seeded From UniProt

complete

involved_in

GO:0043278

response to morphine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6P1F6
ensembl:ENSMUSP00000086640

P

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000009

C

Seeded From UniProt

complete

enables

GO:0019888

protein phosphatase regulator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000009

F

Seeded From UniProt

complete

enables

GO:0019888

protein phosphatase regulator activity

PMID:1849734[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007084

mitotic nuclear envelope reassembly

Reactome:R-HSA-2995410

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-927836
Reactome:R-HSA-927830
Reactome:R-HSA-927813
Reactome:R-HSA-2995388

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-4088141

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Reactome:R-HSA-927802

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Mayer, RE et al. (1991) Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. Biochemistry 30 3589-97 PubMed GONUTS page
  2. ↑ Li, HH et al. (2007) A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J. 26 402-11 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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