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HRSVA:NS1

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Species (Taxon ID) Human respiratory syncytial virus A (strain A2). (11259)
Gene Name(s) 1C (synonyms: NS1)
Protein Name(s) Non-structural protein 1

NS1 Non-structural protein 1C

External Links
UniProt P0DOE9
EMBL M11486
U50362
U50363
U63644
AF035006
PIR A94336
SMR P0DOE9
IntAct P0DOE9
PRIDE P04544
Proteomes UP000007678
UP000134464
UP000181145
UP000181262
UP000181559
GO GO:0033650
GO:0039545
GO:0039502
InterPro IPR005099
Pfam PF03438
ProDom PD009407

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0039501

suppression by virus of host type I interferon production

PMID:15047850[1]

ECO:0000314

P

Figure 3 shows by ELISA that wild type cells expressing NS1 inhibit INF-α and INF-β while cells that have had the NS1 gene removed (ΔNS1) express high levels of the INFs.

complete

involved_in

GO:0039501

suppression by virus of host type I interferon production

PMID:15047850[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0033650

host cell mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1045
UniProtKB-SubCell:SL-0407

C

Seeded From UniProt

complete

involved_in

GO:0030683

evasion or tolerance by virus of host immune response

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0922
UniProtKB-KW:KW-0899

P

Seeded From UniProt

complete

involved_in

GO:0039503

suppression by virus of host innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1090

P

Seeded From UniProt

complete

involved_in

GO:0039502

suppression by virus of host type I interferon-mediated signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1114

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0039545

suppression by virus of host MAVS activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1097

P

Seeded From UniProt

complete

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1035
UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Spann, KM et al. (2004) Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]. J. Virol. 78 4363-9 PubMed GONUTS page