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HRSVA:FUS
Contents
| Species (Taxon ID) | Human respiratory syncytial virus A (strain A2). (11259) | |
| Gene Name(s) | F | |
| Protein Name(s) | Fusion glycoprotein F0
Protein F Fusion glycoprotein F2 Fusion glycoprotein F1 | |
| External Links | ||
| UniProt | P03420 | |
| EMBL | M11486 U50362 U50363 AF035006 U63644 | |
| PIR | A04035 B28929 | |
| PDB | 3IXT 3KPE 3RKI 3RRR 3RRT 4CCF 4JHW 4MMQ 4MMR 4MMS 4MMT 4MMU 4MMV | |
| PDBsum | 3IXT 3KPE 3RKI 3RRR 3RRT 4CCF 4JHW 4MMQ 4MMR 4MMS 4MMT 4MMU 4MMV | |
| ProteinModelPortal | P03420 | |
| SMR | P03420 | |
| DIP | DIP-48772N | |
| TCDB | 1.G.2.1.3 | |
| EvolutionaryTrace | P03420 | |
| Proteomes | UP000007678 | |
| GO | GO:0020002 GO:0016021 GO:0019031 GO:0055036 GO:0019064 GO:0060141 | |
| InterPro | IPR000776 | |
| Pfam | PF00523 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019064 |
fusion of virus membrane with host plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060141 |
positive regulation of syncytium formation by virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019064 |
fusion of virus membrane with host plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039663 |
membrane fusion involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Battles, MB et al. (2016) Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat. Chem. Biol. 12 87-93 PubMed GONUTS page
- ↑ McLellan, JS et al. (2013) Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science 340 1113-7 PubMed GONUTS page
- ↑ Swanson, KA et al. (2011) Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proc. Natl. Acad. Sci. U.S.A. 108 9619-24 PubMed GONUTS page
- ↑ McLellan, JS et al. (2010) Structural basis of respiratory syncytial virus neutralization by motavizumab. Nat. Struct. Mol. Biol. 17 248-50 PubMed GONUTS page
- ↑ Roymans, D et al. (2010) Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein. Proc. Natl. Acad. Sci. U.S.A. 107 308-13 PubMed GONUTS page
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