HPV18:VE1

Species (Taxon ID)	Human papillomavirus type 18. (333761)
Gene Name(s)	E1
Protein Name(s)	Replication protein E1 ATP-dependent helicase E1
External Links
UniProt	P06789
EMBL	X05015 M20325 X04773 A06324 M26798
PIR	C26165
RefSeq	NP_040312.1
PDB	1R9W 1TUE
PDBsum	1R9W 1TUE
ProteinModelPortal	P06789
SMR	P06789
IntAct	P06789
MINT	MINT-94927
GeneID	1489084
EvolutionaryTrace	P06789
Proteomes	UP000009109
GO	GO:0030430 GO:0042025 GO:0005524 GO:0004003 GO:0003677 GO:0032508 GO:0006260 GO:0019079
Gene3D	3.40.50.300
InterPro	IPR001177 IPR014000 IPR014015 IPR027417 IPR016393
Pfam	PF00519 PF00524
PIRSF	PIRSF003383
SUPFAM	SSF52540
PROSITE	PS51206

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030911	TPR domain binding	PMID:19008854	ECO:0000021		UniProtKB:P09914	F		Figure 1B, 1C, 1D, 3B, 3C and 3D. Co-immunoprecipitation assays and immunofluorescence confirm the binding of ATPase HPV18 E1 to the TPR2 domain of P56 protein.	complete
part_of	GO:0042025	host cell nucleus	PMID:19008854	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	PMID:19008854	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019079	viral genome replication	PMID:19008854	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	PMID:19008854	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004003	P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004003	P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004003	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	F		Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001177	P		Seeded From UniProt	complete
enables	GO:0016817	hydrolase activity, acting on acid anhydrides	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014000 InterPro:IPR016393	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	C		Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242300	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
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