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HPV16:VE7
Contents
| Species (Taxon ID) | Human papillomavirus type 16. (333760) | |
| Gene Name(s) | E7 | |
| Protein Name(s) | Protein E7 | |
| External Links | ||
| UniProt | P03129 | |
| EMBL | K02718 D00735 AF003020 AF003023 AF003024 AF003025 AF003026 U76411 U76412 U76413 AF536179 AF536180 | |
| PIR | A03688 | |
| RefSeq | NP_041326.1 | |
| DisProt | DP00024 | |
| ProteinModelPortal | P03129 | |
| DIP | DIP-1090N | |
| IntAct | P03129 | |
| MINT | MINT-87652 | |
| GeneID | 1489079 | |
| Proteomes | UP000009251 | |
| GO | GO:0003677 GO:0046872 GO:0003700 GO:0039645 GO:0039560 GO:0039502 GO:0006351 | |
| InterPro | IPR000148 | |
| Pfam | PF00527 | |
| PIRSF | PIRSF003407 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1990216 |
positive regulation by symbiont of host transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q08050-1) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019056 |
modulation by virus of host transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q08050-1) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046870 |
cadmium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070491 |
repressing transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033613 |
activating transcription factor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070491 |
repressing transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039560 |
suppression by virus of host IRF9 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030838 |
positive regulation of actin filament polymerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P06396) |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0042025 |
host cell nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039650 |
suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000269435 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000269435 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000269435 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039645 |
modulation by virus of host G1/S transition checkpoint |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000269435 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000269435 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000269435 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000269435 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039645 |
modulation by virus of host G1/S transition checkpoint |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060153 |
modulation by virus of host cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Lüscher-Firzlaff, JM et al. (1999) Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation. Oncogene 18 5620-30 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Pahel, G et al. (1993) Structural and functional characterization of the HPV16 E7 protein expressed in bacteria. J. Biol. Chem. 268 26018-25 PubMed GONUTS page
- ↑ Barnard, P & McMillan, NA (1999) The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha. Virology 259 305-13 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Mileo, AM et al. (2013) The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin. Carcinogenesis 34 2424-33 PubMed GONUTS page
d
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- GO:0039650 ! suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
- GO:1990216 ! symbiont-mediated activation of host transcription
- GO:0039502 ! symbiont-mediated suppression of host type I interferon-mediated signaling pathway
- GO:0039560 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity
- GO:0039645 ! symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
